Art

J-GLOBAL ID：201302280164831130   Reference number：13A1156835

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

肥満が誘発する腸内細菌代謝産物が,細胞老化関連分泌表現型を介して肝がん発症を促進する

Author (22)： YOSHIMOTO Shin (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  LOO Tze Mun (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  SATO Seidai (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  HARA Eiji (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  OHTANI Naoko (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  YOSHIMOTO Shin (JST-CREST, Saitama, JPN) ,  LOO Tze Mun (JST-CREST, Saitama, JPN) ,  SATO Seidai (JST-CREST, Saitama, JPN) ,  HONDA Kenya (JST-CREST, Saitama, JPN) ,  HARA Eiji (JST-CREST, Saitama, JPN) ,  LOO Tze Mun (Tokyo Univ. Sci., Chiba, JPN) ,  ATARASHI Koji (RIKEN, Kanagawa, JPN) ,  HONDA Kenya (RIKEN, Kanagawa, JPN) ,  ATARASHI Koji (JST-PRESTO, Saitama, JPN) ,  OHTANI Naoko (JST-PRESTO, Saitama, JPN) ,  KANDA Hiroaki (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  ISHIKAWA Yuichi (Japanese Foundation for Cancer Res., Tokyo, JPN) ,  OYADOMARI Seiichi (Univ. Tokushima, Tokushima, JPN) ,  IWAKURA Yoichiro (Tokyo Univ. Sci., Chiba, JPN) ,  OSHIMA Kenshiro (Univ. Tokyo, Chiba, JPN) ,  HATTORI Masahisa (Univ. Tokyo, Chiba, JPN) ,  MORITA Hidetoshi (Azabu Univ., Kanagawa, JPN)
Material： Nature (London)  (Nature (Lond))
Volume： 499  Issue： 7456  Page： 97-101  Publication year： Jul. 04, 2013 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *metabolite ,  enteric microbe ,  *Obesity ,  cell aging ,  Phenotype ,  *Carcinogenesis ,  mechanism ,  *risk factor ,  Mus musculus ,  *hepatoma ,  DNA lesion ,  bile acid ,  hepatocyte ,  fibroblast ,  tumor process ,  carboxylic acid ,  steroid ,  alicyclic alcohol ,  diol ,  *microbial Metabolite ,  enteric bacteria ,  molecular mechanism ,  Hepatic Stellate Cells ,  Myomorpha
Semi thesaurus term： Appearance of disease mechanism ,  *Alimentary obesity ,  Tumor promotion

JST classification (3)： Carcinogenic mechanisms and factors  (GE02020C) ,  Tumors(=neoplasms)of digestive system  (GH04000D) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (1)： Deoxycholic Acid

Terms in the title (8)： 肥満 ,  誘発 ,  腸内細菌 ,  代謝産物 ,  細胞 ,  老化関連分泌表現型 ,  がん発症 ,  促進