Art

J-GLOBAL ID：201302283319530688   Reference number：13A0817236

Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes

2型糖尿病において不十分なレプチン作用による終末糖化産物受容体の誘導は膵β細胞疲弊を引き起こす

Author (10)： HAN Dong (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  YAMAMOTO Yasuhiko (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  MUNESUE Seiichi (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  MOTOYOSHI So (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  SAITO Hidehito (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  WIN Myat Thu Thu (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  WATANABE Takuo (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN) ,  WATANABE Takuo (Kanazawa Gakuin Coll., Kanazawa, JPN) ,  TSUNEYAMA Koichi (Univ. Toyama, Toyama, JPN) ,  YAMAMOTO Hiroshi (Kanazawa Univ. Graduate School of Medical Sci., Kanazawa, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 18  Issue： 4  Page： 302-314  Publication year： Apr. 2013 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： knockout mouse ,...
Semi thesaurus term： *non-insulin-dependent diabetes mellitus ,...

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JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Other hormones of verterbrates  (EB08070K)

Substance index (2)： Oleic Acid ,  Palmitic Acid

Reference (44)：

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• Coppari, R. & Bjørbæk, C. (2012) Leptin revisited: its mechanism of action and potential for treating diabetes. Nat. Rev. Drug Discov. 11, 692-708.
• Coughlan, M.T., Yap, F.Y., Tong, D.C. et al. (2011) Advanced glycation end products are direct modulators of β-cell function. Diabetes 60, 2523-2532.
• Del Prato, S., Wishner, WJ., Gromada, J. & Schluchter, B.J. (2004) Beta-cell mass plasticity in type 2 diabetes. Diabetes Obes. Metab. 6, 319-331.

Terms in the title (5)： 2型糖尿病 ,  レプチン ,  終末糖化産物受容体 ,  誘導 ,  膵β細胞