Art

J-GLOBAL ID：201302286373193092   Reference number：13A1888383

DNA methylation analysis of BDNF gene promoters in peripheral blood cells of schizophrenia patients

統合失調症患者の末梢血細胞におけるBDNF遺伝子プロモーターのDNAメチル化解析

Author (17)： IKEGAME Tempei (Dep. of Molecular Psychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  IKEGAME Tempei (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  BUNDO Miki (Dep. of Molecular Psychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  SUNAGA Fumiko (Dep. of Molecular Psychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  ASAI Tatsuro (Dep. of Molecular Psychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  ASAI Tatsuro (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  NISHIMURA Fumichika (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  YOSHIKAWA Akane (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  KAWAMURA Yoshiya (Dep. of Psychiatry, Sakae Seijinkai Hospital, 337-1 Kuden-cho, Sakae-ku, Yokohama-shi, Kanagawa 247-0014, JPN) ,  HIBINO Hiroyuki (Dep. of Psychiatry, Fukui Memorial Hospital, 1040-2 Kouenbo, Hatsuse-machi, Miura City, Kanagawa 238-0115, JPN) ,  TOCHIGI Mamoru (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  KAKIUCHI Chihiro (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  SASAKI Tsukasa (Lab. of Health Education, Graduate School of Education, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  KATO Tadafumi (Lab. for Molecular Dynamics of Mental Disorders, RIKEN Brain Sci. Inst., 2-1 Hirosawa, Wako-city, Saitama 351-0198, JPN) ,  KASAI Kiyoto (Dep. of Neuropsychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, JPN) ,  IWAMOTO Kazuya (Dep. of Molecular Psychiatry, Graduate School of Medicine, The Univ. of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo ...) ,  IWAMOTO Kazuya (PRESTO, Japan Sci. and Technol. Agency, 4-1-8, Honcho, Kawaguchi-shi, Saitama 332-0012, JPN)
Material： Neuroscience Research  (神経科学)
Volume： 77  Issue： 4  Page： 208-214  Publication year： Dec. 2013 
JST Material Number： D0210C  ISSN： 0168-0102  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *schizophrenia ,...
Semi thesaurus term： *BDNF gene ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=13A1888383&from=J-GLOBAL&jstjournalNo=D0210C") }}

JST classification (2)： Basic psychiatry  (GR01020I) ,  Gene expression  (EC02040Q)

Reference (40)：

• Campanero, M.R., Armstrong, M.I., Flemington, E.K., 2000. CpG methylation as a mechanism for the regulation of E2F activity. Proc. Natl. Acad. Sci. U.S.A. 97, 6481-6486.
• Carrard, A., Salzmann, A., Malafosse, A., Karege, F., 2011. Increased DNA methylation status of the serotonin receptor 5HTR1A gene promoter in schizophrenia and bipolar disorder. J. Affect. Disord. 132, 450-453.
• Chen, W.G., Chang, Q, Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R., Greenberg, M.E., 2003. Derepression of BDNF transcription involves calciumdependent phosphorylation of MeCP2. Science 302, 885-889.
• D'Addario, C., Dell'Osso, B., Palazzo, M.C., Benatti, B., Lietti, L, Cattaneo, E., Galimberti, D., Fenoglio, C., Cortini, F., Scarpini, E., Arosio, B., Di Francesco, A., Di Benedetto, M., Romualdi, P., Candeletti, S., Mari, D., Bergamaschini, L, Bresolin, N., Maccarrone, M., Altamura, A.C., 2012. Selective DNA methylation of BDNF promoter in bipolar disorder: differences among patients with BDI and BDII. Neuropsychopharmacology 37, 1647-1655.
• Davies, M.N., Volta, M., Pidsley, R., Lunnon, K., Dixit, A., Lovestone, S., Coarfa, C., Harris, R.A., Milosavljevic, A., Troakes, C., Al-Sarraj, S., Dobson, R., Schalkwyk, L.C., Mill, J., 2012. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol. 13, R43.

Terms in the title (7)： 統合失調症患者 ,  末梢血 ,  細胞 ,  BDNF遺伝子 ,  プロモーター ,  DNAメチル化 ,  解析