Art

J-GLOBAL ID：201302292166103377   Reference number：13A0362932

Taurine Ameliorates Impaired the Mitochondrial Function and Prevents Stroke-like Episodes in Patients with MELAS

タウリンはMELAS患者において障害されたミトコンドリア機能を改善し,脳卒中様発作を予防する

Author (9)： RIKIMARU Mitsue (Dep. of Neurology, Kawasaki Medical School, JPN) ,  OHSAWA Yutaka (Dep. of Neurology, Kawasaki Medical School, JPN) ,  WOLF Alexander M. (Dep. of Biochemistry and Cell Biology, Inst. of Dev. and Aging Sciences, Nippon Medical School, JPN) ,  NISHIMAKI Kiyomi (Dep. of Biochemistry and Cell Biology, Inst. of Dev. and Aging Sciences, Nippon Medical School, JPN) ,  ICHIMIYA Harumi (Dep. of Biochemistry and Cell Biology, Inst. of Dev. and Aging Sciences, Nippon Medical School, JPN) ,  KAMIMURA Naomi (Dep. of Biochemistry and Cell Biology, Inst. of Dev. and Aging Sciences, Nippon Medical School, JPN) ,  NISHIMATSU Shin-ichiro (Dep. of Molecular and Developmental Biology, Kawasaki Medical School, JPN) ,  OHTA Shigeo (Dep. of Biochemistry and Cell Biology, Inst. of Dev. and Aging Sciences, Nippon Medical School, JPN) ,  SUNADA Yoshihide (Dep. of Neurology, Kawasaki Medical School, JPN)
Material： Internal Medicine (Web)  (Intern Med (Web))
Volume： 51  Issue： 24  Page： 3351-3357 (J-STAGE)  Publication year： 2012 
JST Material Number： U0033A  ISSN： 1349-7235  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： cell physiology ,...

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JST classification (3)： Basic research of other drugs acting on central nervous system  (GW03120U) ,  Basic neurology  (GN01020W) ,  Central nervous system  (EJ12030F)

Substance index (1)： Taurine

Reference (14)：

• 1. Suzuki T, Nagao A, Suzuki T. Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs. WIREs RNA 2: 376-386, 2011.
• 2. Click FHC. Codon-anticodon pairing: the wobble hypothesis. J Mol Biol 19: 548-555, 1966.
• 3. Curran JF. Modified nucleosides in translation. In: Modification and Editing of RNA. Grosjean H, Benne R, Eds. ASM Press, Washington, D.C, 1998: 493-516.
• 4. Yasukawa T, Suzuki T, Ishii N, Ueda T, Ohta S, Watanabe K. Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNA(Lys) with the MERRF encephalomyopathy pathogenic mutation. FEBS Lett 467: 175-178, 2000.
• 5. Yasukawa T, Suzuki T, Ueda T, Ohta S, Watanabe K. Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. J Biol Chem 275: 4251-4257, 2000.

Terms in the title (7)： タウリン ,  MELAS ,  患者 ,  障害 ,  ミトコンドリア機能 ,  脳卒中様発作 ,  予防