Art

J-GLOBAL ID：201302295054279170   Reference number：12A1812273

Plasma Profiles of Glucose, Insulin and Lipids in the Male WBN/Kob-Lepr^fa Rat, a New Model of Type 2 Diabetes with Obesity

肥満を伴う2型糖尿病の新しいモデル,雄WBN/Kob-Lepr^faラットにおけるグルコース,インシュリンおよび脂質の血漿プロファイル

Author (14)： KAJI Noriyuki (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine) ,  KAJI Noriyuki (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa ...) ,  OKUNO Akira (Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd.) ,  OKUNO Akira (Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  OHNO-ICHIKI Kanako (Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd.) ,  OHNO-ICHIKI Kanako (Shinagawa R&D Center, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  OKI Hisako (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine) ,  OKI Hisako (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa ...) ,  ISHIZAWA Haruya (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine) ,  ISHIZAWA Haruya (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa ...) ,  SHIRAI Mitsuyuki (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine) ,  SHIRAI Mitsuyuki (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa ...) ,  ASAI Fumitoshi (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine) ,  ASAI Fumitoshi (Dep. of Pharmacology, Azabu Univ. School of Veterinary Medicine, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa ...)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 74  Issue： 9  Page： 1185-1189 (J-STAGE)  Publication year： 2012 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 短報  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： obesity ,...
Semi thesaurus term： non-insulin-dependent diabetes mellitus ,...

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JST classification (2)： Medical care and clinical equipment of animals  (FE01020U) ,  Other animal diseases  (FE02060T)

Substance index (1)： Glucose

Reference (16)：

• 1. Akimoto, T., Nakama, K., Katsuta, Y., Zhang, X. J., Ohsuga, M., Ishizaki, M., Sawai, N. and Ozawa, H. 2008. Characterization of a novel congenic strain of diabetic fatty (WBN/Kob-Lepr^fa) rat. Biochem. Biophys. Res. Commun. 366: 556–562.
• 2. Akimoto, T., Terada, M., Shimizu, A., Sawai, N. and Ozawa, H. 2010. The influence of dietary restriction on the development of diabetes and pancreatitis in female WBN/Kob-fatty rats. Exp. Anim. 59: 623–630.
• 3. Aschner, P. 2002. Diabetes trends in Latin America. Diabetes Metab. Res. Rev. 18: S27–S31.
• 4. Berthelier, C., Kergoat, M. and Portha, B. 1997. Lack of deterioration of insulin action with aging in the GK rat: a contrasted adaptation as compared with nondiabetic rats. Metabolism 46: 890–896.
• 5. Bloomgarden, Z. T. 2007. Exploring treatment strategies for type 2 diabetes. Diabetes Care 30: 2737–2745.

Terms in the title (9)： 肥満 ,  2型糖尿病 ,  モデル ,  ラット ,  グルコース ,  インシュリン ,  脂質 ,  血漿 ,  プロファイル