Art

J-GLOBAL ID：201302298168080763   Reference number：13A1145528

A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils

コンフォーメーション的に制約されたフェニルアラニン残基で置換したホルミルペプチドはヒト好中球において選択的な免疫応答を誘導する

Author (8)： HAYASHI Ryo (Dep. of Chemistry, Graduate School of Sci. and Engineering, Saga Univ., 1 Honjo-machi, Saga 840-8502, JPN) ,  MIYAZAKI Masaya (Dep. of Molecular and Material Sciences, Interdisciplinary Graduate School of Engineering Sciences, Kyushu Univ. ...) ,  MIYAZAKI Masaya (Measurement Solution Res. Center, National Inst. of Advanced Industrial Sci. and Technol., Saga 841-0052, JPN) ,  OSADA Satoshi (Dep. of Chemistry, Graduate School of Sci. and Engineering, Saga Univ., 1 Honjo-machi, Saga 840-8502, JPN) ,  KAWASAKI Hiroshi (Dep. of Chemistry, Graduate School of Sci. and Engineering, Saga Univ., 1 Honjo-machi, Saga 840-8502, JPN) ,  FUJITA Ichiro (Fac. of Culture and Education, Saga Univ., Saga 840-8502, JPN) ,  HAMASAKI Yuhei (Dep. of Pediatrics, Fac. of Medicine, Saga Univ., Saga 849-8501, JPN) ,  KODAMA Hiroaki (Dep. of Chemistry, Graduate School of Sci. and Engineering, Saga Univ., 1 Honjo-machi, Saga 840-8502, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 21  Issue： 3  Page： 668-675  Publication year： Feb. 01, 2013 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *Neutrophils ,  *signal transduction receptor ,  *superoxide anion ,  molecule ,  chemical compound ,  chemical synthesis ,  *chemotaxis ,  chemokine ,  *stereoisomer ,  concentration (ratio) ,  toxicity test ,  tripeptide ,  effect concentration 50 ,  Ca2+ mobilization ,  human neutrophils ,  *Receptors, Formyl Peptide ,  Ligands ,  intracellular calcium concentration ,  *immune response ,  derivative compounds
Semi thesaurus term： *immunological reaction ,  FPR1 ,  FPR2 ,  *geometrical isomer ,  derivative

JST classification (4)： Synthesis of drugs  (GV01030F) ,  Immunological reaction in general  (ED03010T) ,  Biophylaxis and immune systems in general  (ED01010F) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (6)： (1R)-1β-[(CHO-L-Met-L-Leu-)Amino]-2α-phenylcyclopropane-1-carboxylic acid methyl ester ,  (1R)-1β-[(CHO-L-Met-L-Leu-)Amino]-2β-phenylcyclopropane-1-carboxylic acid methyl ester ,  (1S)-1α-[(CHO-L-Met-L-Leu-)Amino]-2α-phenylcyclopropane-1-carboxylic acid methyl ester ,  (1S)-1α-[(CHO-L-Met-L-Leu-)Amino]-2β-phenylcyclopropane-1-carboxylic acid methyl ester ,  N-Formylmethionine Leucyl-Phenylalanine ,  fMLP-OMe

Terms in the title (7)： コンフォーメーション ,  制約 ,  フェニルアラニン ,  置換 ,  ヒト好中球 ,  免疫応答 ,  誘導