Harada Hiroshi

ハラダヒロシ | Harada Hiroshi

Affiliation and department：

Research field (6)： Molecular biology , Cell biology , Pathobiochemistry , Radiology , Genomics , Tumor biology

Research theme for competitive and other funds (30)：

2023 - 2026 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発
2021 - 2026 Assessment of the relationship between the dynamics of tumor hypoxia areas and hypoxia inducible factor in radiotherapy for pancreatic cancer
2022 - 2025 Plasma biomarkers for "early detection" and "prognosis prediction" of cancer using intratumoral hypoxia as an indicator
2020 - 2025 Formation of an international research center for integrated radiation science targeting complex systems in living organisms
2021 - 2024 がん個別化放射線治療法の確立に向けたTR研究

2021 - 2024 新規リアルタイムDNA損傷修復応答検出システムの構築と腫瘍内DNA損傷応答の解析

2021 - 2023 悪性固形腫瘍内低酸素がん細胞に対する血中マーカーのゲノムワイドスクリーニング

2020 - 2023 低酸素誘導性分泌蛋白質の利用による腫瘍低酸素のモニタリングと放射線治療効果の増感

2020 - 2022 腫瘍微小環境をドライビングフォースとする腫瘍内遺伝型不均一性の解析

2019 - 2021 A novel invasion-related gene involved in tumor recurrence after radiation therapy

2018 - 2021 Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers

2018 - 2020 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」

2017 - 2020 Interplay between the molecular mechanism for hypoxia response and that for antioxidant capacity

2017 - 2020 Novel gene network responsible for hypoxic response and radioresistance of cancer cells

2016 - 2018 多段階発癌に於ける低酸素応答機構と癌抑制遺伝子のクロストークに迫るオミクス解析

2016 - 2018 放射線被ばくが主要臓器に及ぼす影響に迫る「遺伝子改変動物を用いた時空間解析」

2016 - 2018 Genome-wide Screening of Novel Genes Responsible for Tumor Radioresistance

2014 - 2017 Molecular Mechanisms behind Cancer Cells-specific Oxygen Homeostasis and Their Influence on Tumor Radioresistance

2014 - 2017 Interplay between a circadian clock regulator, PER2, and HIF-1

2014 - 2017 pH恒常性制御による動物個体の形態維持とその破綻

2014 - 2016 Importance of hypoxic regions as cancer stem cell niche; in vivo analyses using a novel mouse model

2014 - 2016 Spatiotemporal analyses of the dynamics of hypoxic tumor cells for the optimization of fractionated radiation therapy for cancers

2013 - 2015 Enhancement of anti-tumor activity of hybrid peptide by complexation with high molecular weight biodegradable polymers

2009 - 2010 Optical Imaging of Intratumoral HIF-1 activity to Optimize Treatment Regimens for Chemoradiotherapy

2005 - 2009 Innovative strategies in radiation therapy targeting tumor hypoxia by biological and physical approaches.

2007 - 2008 Spatiotemporal Analysis of Tumor Microenvironments Relating to Radioresistance of Tumor Cells

2006 - 2008 Investigation on the molecular mechanism of maintenance of oxygen homeostasis by hypoxia-inducible factor 1 system

2006 - 2008 分子標的薬と放射線の併用効果と副作用:マウス肺癌モデルを用いたメカニズムの解明

2007 - 2007 低酸素刺激に応答して蛍光を発する癌細胞を利用した創薬システムの開発

2004 - 2004 放射線治療抵抗性克服に向けた腫瘍低酸素分画の予知と新規治療戦略開発

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Papers (153)：

Takata M, Harada H. AT workshop 2023 -A platform for discussing cutting-edge science in DNA damage signaling, repair, and human disorders-. Genes to Cells. 2023
Chow CCT, Kobayashi M, Kambe G, *Harada H. ZBTB2 is recruited to a specific subset of HIF-1 target loci to facilitate full gene expression under hypoxia. Journal of Molecular Biology. 2023. in press
Jin S, Jin B, Ishikawa T, Ninagawa S, Okada T, Koyasu S, Harada H, Mori K. Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice. Molecular Biology of the Cell. 2023. 34. 3. ar20
Koyasu S, Horita S, Saito K, Kobayashi M, Ishikita H, Chow CCT, Kambe G, Nishikawa S, Menjyu T, Morinibu A, et al. ZBTB2 links p53-deficiency to HIF-1-mediated hypoxia signaling for cancer aggressiveness. EMBO Rep. 2023. 24. 1. e54042
Radiation-induced cell death and resultant tissue injury. 2022. 283. 5. 511-516

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MISC (23)：

子安翔, 子安翔, 西川滋人, 毛受暁史, 原田浩. A novel HIF-1 activator, HPF-4, promotes invasion and growth of p53-deficient cancers. 日本癌学会学術総会抄録集(Web). 2019. 78th
李雪氷, 服部明, 後藤容子, 原田浩, 掛谷秀昭. Involvement of UCHL1 in the HIF1-dependent tumor cell malignancy in 3D cell culture model. 日本癌学会学術総会抄録集(Web). 2019. 78th
Ryota Nakashima, Yoko Goto, Sho Koyasu, Minoru Kobayashi, Michio Yoshimura, Masahiro Hiraoka, Hiroshi Harada. UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization. CANCER SCIENCE. 2018. 109. 453-453
LI Xuebing, 服部明, 後藤容子, 森鳰章代, 平岡眞寛, 原田浩, 原田浩, 原田浩, 掛谷秀昭. UCHL1-HIF-1活性化経路を標的とした分子標的抗がん剤開発研究. 日本薬学会年会要旨集(CD-ROM). 2017. 137th
Masataka Tsuda, Kosai Cho, Masato Ooka, Naoto Shimizu, Reiko Watanabe, Akira Yasui, Yuka Nakazawa, Tomoo Ogi, Hiroshi Harada, Keli Agama, et al. ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair. PloS one. 2017. 12. 11. e0188320

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Patents (9)：

低酸素バイオマーカー及びその利用
低酸素バイオマーカー及びその利用
がんを治療するための医薬組成物
がんを治療するための医薬組成物
新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法

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Books (3)：

Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds).
Lippincott Williams & Milkins. 2012
Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics.
Springer 2009
Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs.
Springer 2006

Lectures and oral presentations (150)：

Tumor hypoxia as a predictor for radiation therapy
(Annual Meeting of European Society for Radiotherapy and Oncology 2023 (ESTRO2023) 2023)
変異KRAS分子標的薬と放射線治療の併用効果に対する腫瘍内酸素環境の影響の考察
(日本癌学会シンポジウム・KRAS分子標的薬の開発 2023)
腫瘍低酸素と放射線抵抗性
(第13回日本放射線腫瘍学会・放射線生物学セミナー 2023)
Hypoxic tumor cells: their dynamics during tumor growth and involvement in recurrence after radiation therapy.
(Sussex-Japan Genome Stability Meeting 2023)
Radioresistance of Hypoxic Tumor Cells.
(The 13th International Symposium on the DNA Damage Response & Human Disease 2022 (isDDRHD-2022) 2022)

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Professional career (1)：

博士(理学) (名古屋大学)

Awards (12)：

2023/06 - Osaka Neuclear Science Association ONSA Award
2022/12 - Japanese Society for Radiation Oncoglogy Abe Award
2018/11 - Journal of Radiation Research JRR Terasima Award Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance
2014/10 - 日本放射線腫瘍学会第12回優秀教育講演賞放射線腫瘍学における"がん幹細胞"と"低酸素"
2013/05 - 公益財団法人放射線影響協会放射線影響研究奨励賞細胞の低酸素応答が放射線感受性に及ぼす影響の解析

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