Rchr
J-GLOBAL ID:201401001478579688
Update date: Sep. 20, 2024
Nakase Hiroshi
ナカセ ヒロシ | Nakase Hiroshi
Affiliation and department:
Research field (1):
Gastroenterology
Research keywords (4):
intestinal epithelial cells
, Macrophage
, cytokine
, mucosal immunology
Research theme for competitive and other funds (19):
- 2022 - 2025 クローン病肛門病変に対する間葉系幹細胞と細胞ファイバ技術を融合した細胞療法の開発
- 2022 - 2025 DOT1L阻害によるインターフェロン応答の機序解明とがん免疫療法への応用
- 2021 - 2024 Functional analysis of small intestinal paneth cells in RalGAPa2 KO mice
- 2020 - 2023 肝細胞癌の分子標的治療と概日時計の関連
- 2020 - 2022 Development of human biopsy-derived intestinal organoids monolayers and application for pharmaceutical research
- 2019 - 2022 Analysis of anti-tumor mechanism underlying inhibition of a histone methyltransferase DOT1L
- 2018 - 2021 The effect of local reactivation of cytomegalovirus in ulcerative colitis-related colorectal cancer
- 2018 - 2021 Effect of circadian clock on liver carcinogenesis based on non-alcoholic steatohepatitis
- 2018 - 2021 Development of personalized medcicine for inflammatory bowel disease based on control of epigenome
- 2016 - 2021 Platform for Advanced Genome Science
- 2016 - 2019 Personal genomics analysis in the inflammatory bowel disease family
- 2015 - 2018 Reconstruction of Intestinal Epithelial Stem Cell Niche and Therapeutic Application
- 2014 - 2017 Elucidation and therapeutic application of bone marrow-intestine coupling
- 2014 - 2017 Analysis of the mechanism responsible for the onset of ulcerative colitis using S100 transgenic rats
- 2013 - 2016 Elucidation of roles of small GTPase Ral and its negative regulator RalGAP in tumorigenesis, and cancer invasion and metastasis
- 2012 - 2015 Functional analysis of small GTP binding protein Ral in colitis-associated cancer
- 2009 - 2011 Elucidation of mechanism of cytomegalovirus reactivation and infection in inflammatory bowel disease.
- 2006 - 2007 New Therapy with CXCL16 Blocking for Inflammatory Bowel Disease
- 2004 - 2005 Development of New device for Regeneration of small intestinal tissue
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Papers (527):
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Yujiro Kawakami, Shinji Yoshii, Masahiro Taniguchi, Yoshiharu Masaki, Taro Sugawara, Yasutoshi Kimura, Hiroshi Nakase. A rare case of delayed duodenal perforation due to an over-the-scope clip. Endoscopy. 2024. 56. S 01. E331-E333
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Tomoya Nakamura, Yoshiharu Masaki, Naohiro Kameyama, Yujiro Kawakami, Keisuke Ishigami, Yumemi Takada, Shuji Satoh, Taro Sugawara, Shintaro Sugita, Hiroshi Nakase. Unique endoscopic features of primary biliary diffuse large B-cell lymphoma: A case report with literature review (with video). DEN Open. 2024. 5. 1
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Tsukasa Yamakawa, Takakazu Miyake, Yoshihiro Yokoyama, Tomoe Kazama, Yuki Hayashi, Daisuke Hirayama, Shinji Yoshii, Hiro-O Yamano, Satoshi Takahashi, Hiroshi Nakase. Clinical performance of fecal calprotectin, lactoferrin, and hemoglobin for evaluating the disease activity of IBD and detecting colorectal tumors. JGH open : an open access journal of gastroenterology and hepatology. 2024. 8. 6. e13077
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Yujiro Kawakami, Yoshiharu Masaki, Keisuke Ishigami, Takehiro Hirano, Ayako Murota, Shintaro Sugita, Hiroshi Nakase. Peroral cholangioscopy-guided biopsy with novel biopsy forceps in comprehensive cancer genomic profiling for cystic duct carcinoma. Endoscopy. 2024. 56. S 01. E414-E415
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Hiroki Kurumi, Yoshihiro Yokoyama, Takehiro Hirano, Kotaro Akita, Yuki Hayashi, Tomoe Kazama, Hajime Isomoto, Hiroshi Nakase. Cytokine Profile in Predicting the Effectiveness of Advanced Therapy for Ulcerative Colitis: A Narrative Review. Biomedicines. 2024. 12. 5
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MISC (304):
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仲瀬 裕志, 潟沼 朗生, 正宗 淳, 福田 晃久. 座談会 膵臓がん克服のためにわれわれがなすべきこととは? : 現在,そして未来. 消化器病学サイエンス = Science of gastroenterology / 「消化器病学サイエンス」編集委員会 編. 2022. 6. 4. 205-214
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Shinji Yoshii, Hiro-o Yamano, Hiroshi Nakase. Novel injectable needle-type knife, ProKnife for colorectal endoscopic submucosal dissection. Digestive Endoscopy. 2021. 33. 6. e137-e139
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Hiroshi Nakase, Takehiro Hirano, Kohei Wagatsuma, Tadashi Ichimiya, Tsukasa Yamakawa, Yoshihiro Yokoyama, Yuki Hayashi, Daisuke Hirayama, Tomoe Kazama, Shinji Yoshii, et al. Artificial intelligence-assisted endoscopy changes the definition of mucosal healing in ulcerative colitis. Digestive Endoscopy. 2021. 33. 6. 903-911
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平野 雄大, 川上 裕次郎, 我妻 康平, 沼田 泰尚, 石上 敬介, 柾木 喜晴, 室田 文子, 本谷 雅代, 阿久津 典之, 佐々木 茂, et al. ステロイド治療によって機能性消化管障害が改善したIgG4関連疾患の1例. 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集. 2021. 129回・123回. 33-33
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青木 敬則, 山本 英一郎, 高澤 啓, 新沼 猛, 山野 泰穂, 萬 顕, 北嶋 洋志, 甲斐 正広, 小山内 誠, 仲瀬 裕志, et al. SMOC1の大腸腫瘍診断マーカーとしての臨床的有用性の検討. 日本癌学会総会記事. 2021. 80回. [P14-4]
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Patents (3):
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ステント、当該ステントを消化管に留置する方法
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病変評価情報生成装置
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画像処理装置及び内視鏡装置
Books (3):
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D.消化管全般にわたるもの 膠原病の消化器病変
南江堂. 2015
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特集炎症性腸疾患診療の最前線 潰瘍性大腸炎の内科治療
日本医師会雑誌 2015
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内科診療Q&A -下部消化管
東京:六法出版社. 1997
Lectures and oral presentations (62):
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難治性潰瘍性大腸炎に対するタクロリムスの粘膜治癒効果に関する検討 -免疫調節剤は生物学的製剤による粘膜治癒を上回るか?-
(第19回日本消化器関連学会週間. 2011)
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内視鏡的狭窄拡張術と免疫調節療法の併用はクローン病患者QOL向上に寄与する.
(第49回小腸研究会 2011)
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IL-17はHSP47の発現を介してクローン病腸管線維化に関与している.
(第19回日本消化器関連学会週間 2011)
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難治性潰瘍性大腸炎に対するタクロリムス治療の手術回避効果とその背景因子に関する検討
(第19回日本消化器関連学会週間. 2011)
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「炎症性腸疾患の免疫病態 -Bench & Bedside-」 炎症性腸疾患病態におけるCXCL16の意義
(第48回日本消化器免疫学会総会. 2011)
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Professional career (1):
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