Kawano Kenichi

カワノケンイチ | Kawano Kenichi

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://www.pharm.kyoto-u.ac.jp/yakkai/

Research field (2)： Bio-, chemical, and soft-matter physics , Pharmaceuticals - chemistry and drug development

Research keywords (7)： peptide , membrane curvature , lipid packing , Extracellular vesicles , drug delivery , membrane proteins , fluorescence imaging

Research theme for competitive and other funds (15)：

2024 - 2027 細胞外小胞の多様性を司る機能性因子の探索:1細胞解析
2023 - 2025 新規リン脂質誘導体可溶化剤を用いた革新的膜タンパク質研究プラットホームの構築
2021 - 2025 In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬
2023 - 2024 腸内細菌に由来する細胞外小胞の免疫増強機構の解明
2023 - 2024 腸内細菌の細胞外膜小胞に由来する免疫活性分子の探索と応用

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Papers (42)：

Kenichi Kawano, Yuki Kuzuma, Koichi Yoshio, Kenta Hosokawa, Yuuto Oosugi, Takahiro Fujiwara, Fumiaki Yokoyama, Katsumi Matsuzaki. Extracellular-vesicle catch-and-release isolation system using a net-charge invertible curvature-sensing peptide. Analytical Chemistry. 2024. 96. 9. 3754-3762
Kenichi Kawano. Elucidation of the Curved Membrane-binding Mechanism of Curvature-sensing Peptides that Enable Highly Sensitive Detection of Extracellular Vesicles. Membrane. 2023. 48. 4. 178-183
Kenichi Kawano, Kouhei Kamasaka, Fumiaki Yokoyama, Jun Kawamoto, Takuya Ogawa, Tatsuo Kurihara, Katsumi Matsuzaki. Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains. Biophysical Chemistry. 2023. 299. 107039-107039
Motoki Nishimura, Yoshimasa Kawaguchi, Kakeru Kuroki, Yuna Nakagawa, Toshihiro Masuda, Takayuki Sakai, Kenichi Kawano, Hisaaki Hirose, Miki Imanishi, Tomoka Takatani-Nakase, et al. Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature. Chemistry - A European Journal. 2023. 29. 29. e202300129
Ruka Yamauchi, Kenichi Kawano, Yousuke Yamaoka, Aoi Taniguchi, Yoshiaki Yano, Kiyosei Takasu, Katsumi Matsuzaki. Development of antimicrobial peptide-antibiotic conjugates to improve the outer membrane permeability of antibiotics against Gram-negative bacteria. ACS Infectious Diseases. 2022. 8. 11. 2339-2347

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MISC (9)：

河野健一. ペプチドと生体膜研究、そして分光学との出会い. 日本薬学会ファルマシア「期待の若手」. 2024. 60. 3
岡野秀亮, 川口祥正, 河野健一, 二木史朗. ペプチド・タンパク質医薬のサイトゾル送達量の定量的評価系構築. 日本薬学会年会要旨集. 2022. 142年会. 27N-pm18S
河野健一. ペプチドが切り拓く小胞研究の新世界〜マーカー発現量に依存しない新たなエクソソーム検出法の開発〜. 月刊「化学」(Review of Chemistry in 2021). 2021. 76. 4. 59-60
河野健一, 中瀬生彦. 中分子創薬研究のフロンティア -生体分子を標的とした機能性ペプチドの創製. 2021. 141年会. S33-2
河野健一, 中瀬生彦. 中分子創薬研究のフロンティア:~ 生体分子の反応集積場としての膜曲率の役割~. 薬事日報(第12286号)P.7. 2020

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Lectures and oral presentations (83)：

ANALYSIS OF THE HYPER-VESICULATING MECHANISM OF SHEWANELLA VESICULOSA HM13 USING A CURVATURE-SENSING PEPTIDE
(14th International Congress on Extremophiles 2024)
Functional evaluation of extracellular vesicles isolated by a novel EV-isolation method using a curvature-sensing peptide
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)
曲率認識ぺプチドによるエクソソーム膜へのアルギニンペプチド修飾と細胞内導入促進
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)
Selective anticancer activities of low pH-responsive anticancer peptides and a peptide-anticancer drug conjugate
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)
Evaluation of Ligand Binding Ability of GPCRs Sollubilized with Novel Phospholipid Derivatives
(The 144th Annual Meeting of the Pharmaceutical Society of Japan 2024)

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Education (4)：

2011 - 2014 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry
2009 - 2011 Kyoto University Graduate School of Pharmaceutical Sciences Division of Physical and Organic Chemistry
2005 - 2009 Okayama University Faculty of Agriculture Department of Agricultural Sciences
2002 - 2005 岡山県立岡山操山高等学校

Professional career (1)：

Ph.D. (Kyoto University)

Work history (5)：

2021/04 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Assistant Professor
2016/04 - 2021/03 Kyoto University Institute for Chemical Research Assistant Professor
2015/10 - 2016/03 Kyoto University Institute for Integrated Cell-Material Sciences (iCeMS) Postdoctoral fellow
2015/07 - 2015/09 Kyoto University Graduate School of Pharmaceutical Sciences Postdoctoral fellow
2014/04 - 2015/06 Kyoto University Institute for Virus Research Limited-term Assistant Professor

Committee career (4)：

2023/04 - 現在京都大学薬友会第75号薬友会誌編集員
2018/08 - 現在若手ペプチド夏の勉強会幹事
2020/03 - 2022/07 生体関連化学部会若手の会関西支部幹事
2019/07 - 2020/10 第42回生体膜と薬物の相互作用シンポジウム(2020) 実行委員・事務局

Awards (3)：

2022/09 - 第19回次世代を担う若手のためのフィジカル・ファーマフォーラム(PPF2022) PPF2022 優秀発表賞「蛍光共鳴エネルギー移動を用いた曲率認識ペプチドによる細胞外小胞の高感度検出法の開発」
2016/07 - The 5th Asia-pacific International Peptide Symposium Poster Prize "Facilitated cell penetration of dipicolylamine-modified R8 by metal complex formation"
2013/10 - 日本薬学会近畿支部第63回日本薬学会近畿支部奨励賞「新規小分子ラベル法とin-cell FRETを用いた膜タンパク質の会合状態の定量的解析」

Association Membership(s) (5)：

The Membrane Society of Japan , Division of Biofunctional Chemistry, The chemical Society of Japan , The Japanese Peptide Society , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE BIOPHYSICAL SOCIETY OF JAPAN

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