Rchr
J-GLOBAL ID：201401008778902426   Update date: Mar. 31, 2025

Nagashima Shigeo

ナガシマ シゲオ | Nagashima Shigeo
Affiliation and department：
Jichi Medical University School of Medicine

About Jichi Medical University School of Medicine


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/60433116.ja.html
Research field  (2)： Virology ,  Molecular biology
Research keywords  (12)： 分子ウイルス学 ,  E型肝炎ウイルス ,  肝炎ウイルス ,  下痢症ウイルス ,  ウイルス感染症 ,  分子疫学 ,  薬剤スクリーニング ,  生物発光タンパク質 ,  電子顕微鏡 ,  エクソソーム ,  感染培養系 ,  感染性cDNAクローン
Research theme for competitive and other funds  (10)：
  • 2022 - 2025 Identification of compounds that inhibit the early and late steps of hepatitis E virus infection and analysis of their inhibitory effects on the virus growth
  • 2019 - 2022 Functional evaluation of the candidate proteins of hepatitis E virus receptor and identification of host factors involved in the permissibility of infection
  • 2016 - 2019 Identification and functional analysis of host factors involved in early steps of hepatitis E virus infection
  • 2013 - 2015 Research on mechanism of hepatitis E virus egress utilizing membrane traffic
  • 2011 - 2012 Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
Show all
Papers (116)：
  • Shigeo Nagashima, Putu Prathiwi Primadharsini, Masaharu Takahashi, Takashi Nishiyama, Kazumoto Murata, Hiroaki Okamoto. Role of Rab13, Protein Kinase A, and Zonula Occludens-1 in Hepatitis E Virus Entry and Cell-to-Cell Spread: Comparative Analysis of Quasi-Enveloped and Non-Enveloped Forms. Pathogens. 2024. 13. 12. 1130-1130
  • Tominari Kobayashi, Masaharu Takahashi, Satoshi Ohta, Yu Hoshino, Kentaro Yamada, Suljid Jirintai, Putu Prathiwi Primadharsini, Shigeo Nagashima, Kazumoto Murata, Hiroaki Okamoto. Production and Characterization of Self-Assembled Virus-like Particles Comprising Capsid Proteins from Genotypes 3 and 4 Hepatitis E Virus (HEV) and Rabbit HEV Expressed in Escherichia coli. Viruses. 2024. 16. 9. 1400-1400
  • Masaharu Takahashi, Tsutomu Nishizawa, Akira Nishizono, Manri Kawakami, Yukihiro Sato, Kazunori Kawakami, Masahiko Irokawa, Tomoko Tamaru, Shinichi Miyazaki, Mizuho Shimada, et al. Recent decline in hepatitis E virus prevalence among wild boars in Japan: Probably due to countermeasures implemented in response to outbreaks of classical swine fever virus infection. Virus research. 2024. 348. 199438-199438
  • Tatsuo Kanda, Tian-Cheng Li, Masaharu Takahashi, Shigeo Nagashima, Putu Prathiwi Primadharsini, Satoshi Kunita, Reina Sasaki-Tanaka, Jun Inoue, Atsunori Tsuchiya, Shingo Nakamoto, et al. Recent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection. Hepatology research : the official journal of the Japan Society of Hepatology. 2024
  • Putu Prathiwi Primadharsini, Masaharu Takahashi, Tsutomu Nishizawa, Yukihiro Sato, Shigeo Nagashima, Kazumoto Murata, Hiroaki Okamoto. The Full-Genome Analysis and Generation of an Infectious cDNA Clone of a Genotype 6 Hepatitis E Virus Variant Obtained from a Japanese Wild Boar: In Vitro Cultivation in Human Cell Lines. Viruses. 2024. 16. 6. 842-842
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MISC (19)：
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Work history (2)：
  • 2024/01 - 現在 自治医科大学 医学部 准教授
  • 2013 - Jichi Medical University School of Medicine
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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