Nishimura Shinichi

ニシムラシンイチ | Nishimura Shinichi

Affiliation and department：
Job title： Professor

Research field (3)： Chemical biology , Molecular biochemistry , Bioorganic chemistry

Research keywords (8)：天然物化学 , ケミカルバイオロジー , 細胞間コミュニケーション , 抗生物質 , 共生物質 , 生体膜脂質 , 金属錯体 , アミノ酸代謝

Research theme for competitive and other funds (18)：

2023 - 2028 Uncovering hidden functions of intrinsic metabolites using chemical genetics and informatics
2023 - 2025 揮発性コミュニケーション分子による異種微生物間相互作用の分子基盤解明
2021 - 2024 マルチターゲットを有する膜脂質の化学オミクス解析
2019 - 2024 Innovative chemical genetics on novel function of endogenous metabolites
2021 - 2023 セリン代謝の化学遺伝学的解析

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Papers (80)：

Ryotaro Yoshizumi, Shunichi Miura, Hiroaki Matoba, Go Hirai, Shumpei Asamizu, Hiroyasu Onaka, Yoko Yashiroda, Akihisa Matsuyama, Minoru Yoshida, Shinichi Nishimura. Glutathione acts as an exometabolite that rescues functionally distinct genetic mutations in fission yeast. 2026
Fereshteh Azadeh, Atsushi Hashimoto, Shinichi Nishimura, Manabu Arioka, Minoru Yoshida, Akihisa Matsuyama. Development of a global screening system for detecting protein-protein interactions by luminescence complementation in fission yeast. Scientific Reports. 2026. 16. 1. 5034
Yojiro Hoshikawa, Natsuho Shirota, Hiroshi Tsugawa, Satoshi Kimura, Akihisa Matsuyama, Yoko Yashiroda, Hideaki Kakeya, Makoto Arita, Reiko Iizumi, Minoru Yoshida, et al. Formation of giant ER sheets by pentadecanoic acid causes lipotoxicity in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 2025. 122. 22. e2422126122
Kazuki Yanagisawa, Kensuke Kaneko, Hiroaki Ikeda, Sumika Iwata, Atsuya Muranaka, Hiroyuki Koshino, Noeka Nagao, Susumu Watari, Shinichi Nishimura, Naoya Shinzato, et al. A new pyranonaphthoquinone, actinoquinonal A, and its congeners from the combined-culture of Streptomyces sp. 23-50 and Tsukamurella pulmonis TP-B0596. The Journal of Antibiotics. 2025
Keisuke Kobayashi, Ryosuke Miyake, Kenichiro Nagai, Yukino Sato, Reiko Seki, Kumiko Sakai-Kato, Shinichi Nishimura, Taichi Ohshiro, Hiroshi Tomoda. Nectriatides with no antifungal activity bind to ergosterol and potentiate the antifungal activity of amphotericin B against Candida albicans. 2025

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MISC (36)：

竹中慧, 西村慎一, 金子賢介, LU Shan, 掛谷秀昭. Study on a new prodrug methodology inspired by a natural product saccharothriolide B. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
浅水俊平, 尾崎太郎, 尾崎太郎, 西村慎一, 西村慎一, 掛谷秀昭, 尾仲宏康. 複合培養におけるStreptomyces sp.HEK616による5aTHQの生産機構. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
浅水俊平, 浅水俊平, 尾崎太郎, 西村慎一, 掛谷秀昭, 尾仲宏康, 尾仲宏康. Streptomyces sp.HEK616とTsukamurella pulmonisとの複合培養での二次代謝活性化機構の解析. 日本放線菌学会大会講演要旨集. 2019. 34th
西村慎一, 掛谷秀昭, 松森信明. 生体膜を標的にする天然有機化合物天然物による厳密な脂質認識とそれに基づく表現型. 化学と生物. 2018. 56. 10. 678-685-684
西村慎一, 西村慎一, 杉山龍介, 仲谷崇宏, 尾崎太郎, 浅水俊平, 尾仲宏康, 掛谷秀昭. Membrane Affinity and Biological Activities of 5aTHQs, Combined-culture Metabolites. 天然有機化合物討論会講演要旨集(Web). 2018. 60th

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Patents (5)：

Education (3)：

2001 - 2004 The University of Tokyo Graduate School of Agricultural and Life Sciences
1999 - 2001 The University of Tokyo Graduate School of Agricultural and Life Sciences
1995 - 1999 The University of Tokyo

Professional career (1)：

PhD (The University of Tokyo)

Work history (9)：

2023/01 - 現在 Hiroshima University Graduate School of Integrated Sciences for Life Professor
2021/04 - 2023/03 Meiji University Graduate School of Agriculture
2018/03 - 2022/12 The University of Tokyo Graduate School of Agricultural and Life Sciences Lecturer
2009/04 - 2018/02 Kyoto University Graduate School of Pharmaceutical Sciences Division of Bioinformatics and Chemical Genomics
2016/08 - 2017/08 University of California San Diego Scripps Institution of Oceanography

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Committee career (3)：

2026/03 - 現在 Journal of Natural Products Topic Editor
2023/07 - 現在 Biochimica et Biophysica Acta (BBA) - General Subjects Editorial Board Member
2021/03 - 2025/02 日本農芸化学会和文誌編集委員

Awards (2)：

2020/07 - 公益財団法人日本感染症医薬品協会住木・梅澤記念賞生体膜を標的にする抗真菌化合物の探索と作用機序に関する研究
2020/04 - 公益財団法人長瀬科学技術振興財団長瀬研究振興賞分裂酵母プロテオームを基盤にした抗真菌化合物セオネラミドの包括的作用解明

Association Membership(s) (6)：

日本脂質生化学会 , 日本分子生物学会 , 日本農芸化学会 , 日本薬学会 , 酵母遺伝学フォーラム , 日本ケミカルバイオロジー学会

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