MIKI DAIKI

ミキダイキ | MIKI DAIKI

Affiliation and department：

Research field (1)： Gastroenterology

Research keywords (5)： Hepatology , Gastroenterology , Human Genome , Gut microbiota , hepatitis virus

Research theme for competitive and other funds (21)：

2021 - 2024 ヒト肝細胞キメラマウスモデルとヒト組織学的進展例材料を用いたNASHの研究
2020 - 2023 Study of factors associated with health status and prognosis after successful HCV eradication
2020 - 2023 Risk prediction for development of non-viral hepatocellular carcinoma using the human genome and microbiome by machine learning
2021 - 2022 Research for HBV therapy development based on the establishment of HBV-sensitive cell and animal models
2020 - 2022 Analysis of HBV life cycle by using sophisticated reporter HBV systems and its application to the development of a new strategy to suppress HBV infection and replication

2019 - 2022 Study of outcome of liver cirrhotic patients received HCV elimination therapy

2017 - 2022 Hepatitis B virus eradication therapy development using a highly efficient cell culture system and a long term active chronic hepatitis B mouse model

2018 - 2020 Exploring etiologies, sub-classification, and risk prediction of diseases based on big-data analysis of clinical and whole omics data in medicine

2017 - 2020 2本鎖DNAを使用せず高度の安全性を保証する遺伝子治療の開発

2017 - 2020 Identification of novel genetic factors and genetic risk assessment models for non-viral HCC

2017 - 2020 C型肝炎ウイルス排除後の病態、生命予後、QOLに関する包括的研究

2018 - 2019 Development of Japanese sake-related functional foods which can modify gut flora in Higashihiroshima City

2017 - 2019 A study of the effect of dysbiosis on peripheral blood microvesicles in patients with liver diseases and the application as biomarkers

2017 - 2018 Identification of host genetic factors and genetic risk assessment models for development of HCC after HCV eradication

2016 - 2018 Immunogenomics approach to clarify the mechanism of hepatocarcinogenesis

2016 - 2018 Identification of HCC-specific exosomes and exosomal miRNAs

2015 - 2017 Integrative multi-omics analysis of interactions between obesity, diabetes mellites and NASH

2014 - 2017 The effects of genetic polymorphisms in viral sensing pathways on the development of viral hepatitis

2014 - 2017 ヒト肝細胞キメラマウスを用いた薬剤耐性、臓器不全等治療困難症例に対する病態解析と根治的治療法の開発に関する研究

2013 - 2016 Comprehensive analysis of miRNA polymorphisms which affect clinical and pathological conditions in chronic viral hepatitis

2011 - 2011 A genome-wide association study identified a novel susceptibility locus for hepatocellular carcinoma in chronic hepatitis C virus carriers (AASLD 2011, San Francisco)

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Papers (205)：

Shirane, Yuki, Fujii, Yasutoshi, Ono, Atsushi, Nakahara, Hikaru, Hayes, Clair Nelson, Miura, Ryoichi, Murakami, Serami, Sakamoto, Naoya, Uchikawa, Shinsuke, Fujino, Hatsue, et al. Peripheral T Cell Subpopulations as a Potential Surrogate Biomarker during Atezolizumab plus Bevacizumab Treatment for Hepatocellular Carcinoma. CANCERS. 2024. 16. 7
Johira, Yusuke, Nakahara, Takashi, Yamaoka, Kenji, Fujii, Yasutoshi, Uchikawa, Shinsuke, Fujino, Hatsue, Ono, Atsushi, Murakami, Eisuke, Kawaoka, Tomokazu, Miki, Daiki, et al. Impact of MAFLD criteria on postoperative recurrence of non-B, non-C HCC. EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. 2024. 36. 4. 430-437
Kinami, Takahiro, Uchikawa, Shinsuke, Kawaoka, Tomokazu, Yamasaki, Shintaro, Kosaka, Masanari, Johira, Yusuke, Yano, Shigeki, Amioka, Kei, Naruto, Kensuke, Yamaoka, Kenji, et al. Efficacy and safety of atezolizumab plus bevacizumab in patients with portal hypertension for unresectable hepatocellular carcinoma. CANCER MEDICINE. 2024. 13. 5
Ichikawa, Akemi, Miki, Daiki, Hayes, C. Nelson, Teraoka, Yuji, Nakahara, Hikaru, Tateno, Chise, Ishida, Yuji, Chayama, Kazuaki, Oka, Shiro. Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice. SCIENTIFIC REPORTS. 2024. 14. 1
Tahata Y, Hikita H, Mochida S, Enomoto N, Ido A, Kuroda H, Miki D, Kurosaki M, Hiasa Y, Sakamori R, Kawada N, Yamashita T, Suda G, Yatsuhashi H, Yoshiji H, Kato N, Takami T, Nakao K, Matsuura K, Asahina Y, Itoh Y, Tateishi R, Nakamoto Y, Kakazu E, Terai S, Shimizu M, Ueno Y, Akuta N, Miyazaki M, Nozaki Y, Kabayama M, Sobue S, Moriuchi A, Miyaki T, Kodama T, Tatsumi T, Yamada T, Takehara T. Posttreatment liver function, but not baseline liver function stratifies patient survival after direct-acting antiviral treatment in decompensated cirrhosis with hepatitis C virus. JOURNAL OF GASTROENTEROLOGY. 2023. 58. 12. 1211-1221

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MISC (69)：

Daiki Miki, Hiroshi Aikata, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Masataka Tsuge, Kazuaki Chayama. Genetic polymorphism in PNPLA3 is associated with hepatocellular carcinoma after hepatitis C virus eradication. CANCER SCIENCE. 2021. 112. 486-486
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. GENETIC POLYMORPHISM OF IP-10, NOT IFNL4 OR HLA-DPS, AFFECTS LIVER INFLAMMATION IN CHRONIC HEPATITIS B PATIENTS. HEPATOLOGY. 2019. 70. 412A-413A
Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, et al. ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS. HEPATOLOGY. 2019. 70. 1050A-1051A
Daiki Miki, Yumi Shimomura, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Maiko Numba, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, et al. A COMPREHENSIVE ANALYSIS OF A WIDE RANGE OF LIVER DISEASES BY 16S rRNA SEQUENCING REVEALS CHARACTERISTIC PATTERNS OF GUT MICROBIOTA IN EACH ETIOLOGY. HEPATOLOGY. 2019. 70. 1163A-1164A
Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. INDEPENDENT IMPACT OF POLYMORPHISM IN IRF5 AS WELL AS STAT4 ON HBV-RELATED HEPATOCARCINOGENESIS. HEPATOLOGY. 2019. 70. 1190A-1190A

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Books (15)：

Gastroenterology & Hepatology, 10(6): 718-723
2021
消化器内科:第6号(Vol.2, No.5, 2020),pp76-82
医学出版 2020
消化器・肝臓内科:3巻1号, pp60-68
科学評論社 2018
ゲノムから表現型までの多階層統合的解析による肥満および糖尿病と脂肪肝炎との相互作用メカニズムの解明
鈴木謙三記念医科学応用研究財団 2016
日本臨牀:73巻増刊号1, pp213-216
日本臨牀社 2015

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Lectures and oral presentations (151)：

切除不能肝細胞癌に対するデュルバルマブ・トレメリムマブ併用療法の初期治療成績
(第45回日本肝臓学会西部会 2023)
B型慢性肝疾患患者における肝発癌予測因子としての血清 PreS1/HBsAg 比の有用性
(第45回日本肝臓学会西部会 2023)
急性肝不全患者における血清炎症性サイトカインを含めた予後予測因子の検討
(第45回日本肝臓学会西部会 2023)
切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ PD 症例におけるレンバチニブの治療成績について
(第45回日本肝臓学会西部会 2023)
2型糖尿病合併 NAFLD に対する SGLT2阻害剤の有効性の検討
(第76回広島医学会総会 2023)

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Education (4)：

2006 - 2010 Hiroshima University Graduate School of Biomedical Sciences
2006 - 2010 Hiroshima University Graduate School of Biomedical Sciences
1994 - 2000 Hiroshima University Faculty of Medicine
1994 - 2000 Hiroshima University Faculty of Medicine

Professional career (1)：

Doctor of Philosophy in Medical Sciences (Hiroshima University)

Work history (12)：

2024/06 - 現在 Hiroshima University
2019/04/01 - 2024/05/31 Hiroshima University Graduate School of Biomedical and Health Sciences Lecturer
2018/04/01 - 2019/03/31 Hiroshima University Graduate School of Biomedical & Health Sciences Lecturer
2014/08 - 2018/03 RIKEN Center for Integrative Medical Sciences Laboratory for Digestive Diseases Deputy Team Leader
2014/08 - 2018/03 RIKEN Center for Integrative Medical Sciences Laboratory for Digestive Diseases Deputy Team Leader

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Committee career (7)：

2021/04 - 2022/03 The Japanese Society of Hepatology Councilor of the West Branch
2020/04 - 2021/03 The Japanese Society of Hepatology Councilor of the West Branch
2019/04 - 2020/03 The Japanese Society of Hepatology Councilor of the West Branch
2018/04 - 2019/03 The Japanese Society of Hepatology Councilor of the West Branch
2017/04 - 2018/03 The Japanese Society of Hepatology Councilor of the West Branch

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Awards (7)：

2021/04/15 - The Japanese Society of Gastroenterology Incitement Award of the Japanese Society of Gastroenterology PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication
2013/11/05 - The American Association for the Study of Liver Diseases Presidential Poster of Distinction HLA-DQ confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study
2012/10/10 - The Japanese Society of Hepatology 5th CHUGAI Award of the Japanese Society of Hepatology Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers
2011/11/05 - The American Association for the Study of Liver Diseases Young Investigator Liver Cancer Research Award A genome-wide association study identified a novel susceptibility locus for hepatocellular carcinoma in chronic hepatitis C virus carriers
2011/10/05 - The Japanese Cancer Association Incitement Award of the Japanese Cancer Association Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations

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Association Membership(s) (12)：

Japanese Association for Cancer Detection and Diagnosis , The Japanese Society of Gastrointestinal Cancer Screening , Japanese Society of Medical Oncology , The Japanese Association for RNA interference , The Liver Cancer Study Group of Japan , The Japanese Society of Internal Medicine , The Japan Gastroenterological Endoscopy Society , The Molecular Biology Society of Japan , The Japan Society of Human Genetics , The Japanese Society of Gastroenterology , The Japanese Cancer Association , The Japanese Society of Hepatology

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