Research theme for competitive and other funds (5)：
2021 - 2024 「リポペプチド免疫」に着目した自己免疫の新機軸
2018 - 2021 Novel strategy of host defense targeted for "viral lipopeptides"
2016 - 2018 Identification and functional analysis of a novel class of human MHC class I molecules presenting lipopeptide antigens
2014 - 2016 Crystallographic analysis of the MHC class I:lipopeptide complex and identification of the lipopepitide-angigen presentation pathway
2013 - 2015 「リポペプチド」を提示するMHCクラスI分子の同定とその免疫機能解析
Papers (23)：
Daisuke Morita, Minori Asa, Masahiko Sugita. Engagement with the TCR induces plasticity in antigenic ligands bound to MHC class I and CD1 molecules. International immunology. 2023. 35. 1. 7-17
Asa Minori, Morita Daisuke, Sugita Masahiko. T Cell activation and responses(human and Vitro)(Dynamic B-pocket remodeling is a basis for HLA class I molecules to bind peptides and lipopeptides). 日本免疫学会総会・学術集会記録. 2022. 51. Proceedings. WS26-O/P
Minori Asa, Daisuke Morita, Jin Kuroha, Tatsuaki Mizutani, Naoki Mori, Bunzo Mikami, Masahiko Sugita. Crystal structures of N-myristoylated lipopeptide-bound HLA class I complexes indicate reorganization of B-pocket architecture upon ligand binding. Journal of Biological Chemistry. 2022. 298. 7. 102100-102100
Lipopeptide antigen presentation mediated by classical MHC class I molecules.
(The 13th International CD1-MR1 Conference. 2024)
N-myristoylated lipopeptide-specific T cell development independently of TAP transporters.
(The 52nd Annual Meeting of the Japanese Society for Immunology. 2024)
A molecular basis for specific recognition of lipopeptides by TCRs.
(The 51th Annual Meeting of the Japanese Society for Immunology 2022)
Crystal structure of the ternary complex of TCR, MHC class I and lipopeptides.
(The 50th Annual Meeting of the Japanese Society for Immunology 2021)
T-cell recognition of the lipopeptide-bound MHC class I complex; evidence from the crystal structure
(The 15th International Symposium of the Institute Network for Biomedical Sciences 2020 2020)
