Okuno Yukiko

Affiliation and department：

Research field (2)： Pharmaceuticals - chemistry and drug development , Molecular biology

Research theme for competitive and other funds (5)：

2015 - 2020 Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models
2015 - 2016 トランスクリプトームの人為的操作による遺伝病の治療
2003 - 2006 真核生物染色体DNA複製フォークの分子ダイナミズム
2005 - 2005 DNAポリメラーゼεミューテーター変異マウスの構築とその発がん機構の解析
2004 - 2005 ほ乳細胞における複製開始点の同定とその制御機構の解析

Papers (32)：

Julia Kitadokoro, Shigeki Kamitani, Yukiko Okuno, Takaaki Hikima, Masaki Yamamoto, Takatsugu Hirokawa, Kengo Kitadokoro. Crystal structure of Staphylococcus aureus lipase complex with unsaturated petroselinic acid. FEBS Open Bio. 2024
Takashi Matsuoka, Aiko Sugiyama, Yoshifumi Miyawaki, Yusuke Hidaka, Yukiko Okuno, Hiroaki Sakai, Hiroki Tanaka, Kiyotsugu Yoshikawa, Tomohiro Fukui, Kei Mizuno, et al. Newly developed preclinical models reveal broad-spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide. Cancer science. 2023
北所健悟, 奥野友紀子, 引間孝明, 山本雅貴, 神谷重樹. 最先端医療の今抗肥満薬が黄色ブドウ球菌の病原因子を阻害するメカニズムを解明. Medical Science Digest. 2023. 49. 11. 598-599
Motoyasu Hosokawa, Ryuta Mikawa, Atsuko Hagiwara, Yukiko Okuno, Tomonari Awaya, Yuki Yamamoto, Senye Takahashi, Haruka Yamaki, Mitsujiro Osawa, Yasuhiro Setoguchi, et al. Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC. iScience. 2023. 107731-107731
Ichiro Yamauchi, Yoriko Sakane, Yukiko Okuno, Taku Sugawa, Takuro Hakata, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Takafumi Yamashita, Keisho Hirota, et al. High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases. Endocrinology. 2022. 163. 8

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MISC (35)：

北所健悟, 奥野友紀子, 引間孝明, 山本雅貴, 神谷重樹. Mechanism of inhibition of Staphylococcus aureus virulence factor by anti-obesity drugs. 月刊メディカル・サイエンス・ダイジェスト. 2023. 49. 11
小林亜希子, 粟屋智就, 喜井勲, 隅田有人, 奥野友紀子, 和根崎圭子, 吉田優, 隅田ともえ, 井上治久, 細谷孝充, et al. 神経新生促進によるダウン症モデルにおける脳発達障害の是正. 生命科学系学会合同年次大会. 2017. 2017年度. [2AT26-1060)]
奥勇紀, 奥野友紀子, 萩原正敏, 寳関淳, 寳関淳, 阪井康能, 阪井康能. 小胞体でのミスフォールドタンパク質蓄積に伴うレドックス異常回復剤の同定とその機序について. 日本農芸化学会大会講演要旨集(Web). 2017. 2017. ROMBUNNO.2A02p07 (WEB ONLY)
小林亜希子, 粟屋智就, 喜井勲, 隅田有人, 奥野友紀子, 和根崎圭子, 吉田優, 隅田ともえ, 井上治久, 細谷孝充, et al. 神経新生促進によるダウン症モデルにおける脳発達障害の是正. 日本生化学会大会(Web). 2017. 90th. [2P-10)]
寳関淳, 寳関淳, 奥勇紀, 藤村多嘉朗, 大石麻水, 奥野友紀子, 萩原正敏, 阪井康能, 阪井康能. 小胞体における異常タンパク質蓄積に伴うレドックス変化とこれを回復させる薬剤探索系の開発. 日本細胞生物学会大会(Web). 2016. 68th. ROMBUNNO.P2-13 (WEB ONLY)-89

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Professional career (1)：

博士(理学) (名古屋大学)

Work history (9)：

2018/04/01 - - -
2011/04/01 - Graduate School of Medicine, Kyoto University Research Assistant Professor
2007/05/16 - Graduate School of Biomedical Science, Tokyo Medical and Dental University Research Assistant Professor
2006/04/01 - Department of Biological Science, Graduate School of Sciences, Nagoya University Research Fellow
2005/07/01 - Graduate School of Frontier Biosciences, Osaka University Assistant Professor

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Association Membership(s) (6)：

International Chemical Biology Society , The Japanese Society for Virology , The Japan Society of Hepatology , Japanese Society for Chemical Biology , The Japanese Pharmacological Society , The Molecular Biology Society of Japan

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