YAMASHITA Mitsuaki

ヤマシタミツアキ | YAMASHITA Mitsuaki

Affiliation and department：
Job title：准教授
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/20433641.ja.html

Research field (2)： Bioorganic chemistry , Pharmaceuticals - chemistry and drug development

Research keywords (6)：生物有機化学 , 天然物化学 , 有機金属 , 合成化学 , 不斉合成 , 有機化学

Research theme for competitive and other funds (3)：

2012 - 2013 Development of the synthesis of heterocycle-fused naphthoquinones toward specific substrate for DT-diaphorase
2011 - 2012 Development of a novel chelating agent suitable for the prelabeling to establish a generic method for preparation of radiolabeled antibodies.
2007 - 2008 Construction of multi-substituted heterocycles by asymmetric alkynylation reaction

Papers (35)：

Nobutaka Numoto, Fumiya Kondo, Gert-Jan Bekker, Zengwei Liao, Mitsuaki Yamashita, Akira Iida, Nobutoshi Ito, Narutoshi Kamiya, Masayuki Oda. Structural dynamics of the Ca2+-regulated cutinase towards structure-based improvement of PET degradation activity. International journal of biological macromolecules. 2024. 281. Pt 4. 136597-136597
Mitsuaki Yamashita, Akari Nakanishi, Chiehming Chang, Kosei Tsurushima, Kiyoshige Nakamoto, Akira Iida. Evaluation of STAT3 Inhibition by Cancer Chemopreventive Trichothecenes Derived from Metabolites of Trichothecium roseum. Chemical & pharmaceutical bulletin. 2024. 72. 7. 693-699
Mitsuaki Yamashita, Yuto Nakamori, Arisa Tsukamoto, Nagisa Furuno, Akira Iida. Synthesis and structure-activity relationship studies of naphthoquinones as STAT3 inhibitors. Bioorganic & medicinal chemistry. 2023. 90. 117331-117331
Fusako Kawai, Yoshitomo Furushima, Norihiro Mochizuki, Naoki Muraki, Mitsuaki Yamashita, Akira Iida, Rie Mamoto, Takehiko Tosha, Ryo Iizuka, Sakihito Kitajima. Efficient depolymerization of polyethylene terephthalate (PET) and polyethylene furanoate by engineered PET hydrolase Cut190. AMB Express. 2022. 12. 1. 134-134
Akane Senga, Nobutaka Numoto, Mitsuaki Yamashita, Akira Iida, Nobutoshi Ito, Fusako Kawai, Masayuki Oda. Multiple structural states of Ca2+-regulated PET hydrolase, Cut190, and its correlation with activity and stability. Journal of biochemistry. 2021. 169. 2. 207-213

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MISC (74)：

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Patents (6)：

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Books (1)：

Lectures and oral presentations (10)：

Copper-mediated Oxidative Tandem Reactions: One-pot synthesis of Polyhydropyrido[1,2-a]indoles and Tetracyclic Quinazolinones from 2-Arylindoles
(18th TETRAHEDRON SYMPOSIUM Asia Edition 2017)
銅触媒による酸化的タンデム反応の開発: pyrido[1,2-a]indolesとtetracyclic quinazolinonesの2-アリールインドールからのワンポット合成
(日本薬学会第137年会(仙台) 2017)
DNAトポイソメラーゼII型阻害剤とヒストン脱アセチル化酵素阻害剤とのハイブリッド化合物の合成と評価
(日本薬学会第136年会(横浜) 2016)
DNA トポイソメラーゼII型阻害剤とトリコスタチン類縁体とのハイブリッド化合物の合成と評価
(第65 回日本薬学会近畿支部総会・大会(大阪) 2015)
銅触媒と分子状酸素を用いた2-アリールインドールの酸化的タンデム反応の開発
(日本薬学会第135年会(神戸) 2015)

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Education (3)：

Professional career (1)：

Work history (3)：

Association Membership(s) (3)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE CHEMICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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