Kodan Atsushi

コダンアツシ | Kodan Atsushi

Research field (5)： Molecular biology , Cell biology , Pharmacology , Structural biochemistry , Applied biochemistry

Research keywords (7)：脂質代謝 , nascent HDL , drug discovery , structure based molecular mechanism , conformational change , conformation and activity relationship , biological macromolecule

Research theme for competitive and other funds (7)：

2021 - 2025 細胞外基質による細胞機能制御機構の包括的理解とその応用基盤の研究
2020 - 2023 脂質輸送型ABC蛋白質の分子構造と役割の解明
2017 - 2020 Structural Basis for drug transport by ABC transporters
2012 - 2015 Elucidation of the molecular mechanism of ABC transporters
2010 - 2011 X-ray crystallographic analysis of an ABC transporter

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Papers (22)：

Atsushi Kodan, Romain Amyot, Kenichi Umeda, Fumihiko Ogasawara, Yasuhisa Kimura, Noriyuki Kodera, Kazumitsu Ueda. Direct Visualization of ATP-Binding Cassette Protein A1 Mediated Nascent High-Density Lipoprotein Biogenesis by High-Speed Atomic Force Microscopy. Nano letters. 2025. 25. 36. 13563-13570
Takumi Takeda, Motoki Shimizu, Atsushi Kodan, Hiroe Utsushi, Eiko Kanzaki, Satoshi Natsume, Tomoya Imai, Kaori Oikawa, Akira Abe, Ryohei Terauchi. Multipartite coevolution shapes plant apoplastic immunity against rice blast fungus. 2025
Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
Fumihiko Ogasawara, Atsushi Kodan, Kazumitsu Ueda. ABC proteins in evolution. FEBS letters. 2020. 594. 23. 3876-3881
Ryota Futamata, Fumihiko Ogasawara, Takafumi Ichikawa, Atsushi Kodan, Yasuhisa Kimura, Noriyuki Kioka, Kazumitsu Ueda. In vivo FRET analyses reveal a role of ATP hydrolysis-associated conformational changes in human P-glycoprotein. Journal of Biological Chemistry. 2020. 295. 15. 5002-5011

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MISC (59)：

Atsushi Kodan, Romain Amyo, Yasuhisa Kimura, Noriyuki Kodera, Kazumitsu Ueda. Direct Visualization of ABCA1 Reconstituted in Nanodisc by High-Speed Atomic Force Microscopy (HS-AFM). ABC2023, the 9th FEBS Special Meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Disease”. 2023
小段篤史, 光岡薫, 木村泰久, 木岡紀幸, 植田和光. Expression and purification of a lipid efflux ABC protein aiming for Cryo-EM analysis. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
小段篤史, 木村泰久, 植田和光. 多剤排出ポンプMDR1の薬剤絞り出しメカニズム. トランスポーター研究会年会抄録集. 2020. 15th
小段篤史, 木村泰久, 植田和光. 多剤排出ポンプMDR1の薬剤絞り出し機構. ファルマシア(Web). 2020. 56. 6
大山諒, 潘東青, 中津亨, 佐藤友美, 山口知宏, 小段篤史, 植田和光, 岩田想, 加藤博章. X 線自由電子レーザーを用いたP糖タンパク質ホモログの連続フェムト秒X線結晶構造解析. 第14回次世代を担う若手のためのフィジカル・ファーマフォーラム. 2016

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Books (5)：

BIOSCIENCE & INDUSTRY
2021
ファルマシア
日本薬学会 2020
膜タンパク質工学ハンドブック
エヌ・ティー・エス 2020 ISBN:9784860435370
未来材料
エヌ・ティー・エス 2006
ABC蛋白質
学会出版センター 2005 ISBN:4762230421

Lectures and oral presentations (8)：

Direct Visualization of ABCA1 Reconstituted in Nanodisc by High-Speed Atomic Force Microscopy (HS-AFM)
(ABC2023, the 9th FEBS Special Meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Disease” Innsbruck, Austria 2023)
Cryo-EM解析を目指した脂質輸送型ABC蛋白質の生産・調製基盤の構築
(日本農芸化学大会2021年度大会 (オンライン開催) 2021)
多剤排出ポンプMDR1の薬剤絞り出しメカニズム
(第15回トランスポーター研究会年会 (オンライン開催) 2020)
Structural basis for gating mechanisms of a eukaryotic ABC transporter
(WPI-iCeMS Industry Advisory Committee Conference 2014)
High-resolution crystal structure of an ABC multidrug exporter from Cyanidioschyzon merolae, a thermophilic unicellular eukaryote
(ABC2014, the 5th FEBS Special Meeting “ATP-Binding Cassette Proteins: From Multidrug Resistance to Genetic Disease” 2014)

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Professional career (1)：

Ph.D. (Kyoto University)

Association Membership(s) (4)：

Japan Society for Bioscience, Biotechnology, and Agrochemistry , SPring-8ユーザー共同体(SPRUC)X線自由電子レーザーXFEL利用研究会会員 , SPring-8ユーザー共同体(SPRUC)放射光構造生物学研究会 , The Japanese Biochemical Society

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