Rchr
J-GLOBAL ID：201401043289847951   Update date: Sep. 16, 2024

Okae Hiroaki

オカエ ヒロアキ | Okae Hiroaki
Affiliation and department：
Kumamoto University

About Kumamoto University


Job title： Professor
Homepage URL  (1)： https://www.imeg.kumamoto-u.ac.jp/bunya_top/trophoblast_research/
Research field  (1)： Developmental biology
Research keywords  (4)： Trophoblast stem cell ,  DNA methylation ,  Genomic imprinting ,  Placenta
Research theme for competitive and other funds  (16)：
  • 2024 - 2028 Implantation organoid model using human multilevel stem cells and elucidation of immune tolerance mechanism
  • 2024 - 2028 ヒト胎盤の発生を支える分子基盤の包括的な理解
  • 2024 - 2026 Investigation of a novel genomic imprinting mechanism in the human placenta
  • 2021 - 2024 ヒト胎盤幹細胞を用いた革新的な周産期疾患モデリング
  • 2019 - 2024 着床前胚に由来する幹細胞を用いた全能性の再構築
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Papers (44)：
  • Shun Shibata, Shun Endo, Luis A. E. Nagai, Eri H. Kobayashi, Akira Oike, Norio Kobayashi, Akane Kitamura, Takeshi Hori, Yuji Nashimoto, Ryuichiro Nakato, et al. Modeling embryo-endometrial interface recapitulating human embryo implantation. Science Advances. 2024. 10. 8
  • Takeshi Hori, Hiroaki Okae, Shun Shibata, Norio Kobayashi, Eri H Kobayashi, Akira Oike, Asato Sekiya, Takahiro Arima, Hirokazu Kaji. Trophoblast stem cell-based organoid models of the human placental barrier. Nature communications. 2024. 15. 1. 962-962
  • Takanori Shimizu, Akira Oike, Eri H Kobayashi, Asato Sekiya, Norio Kobayashi, Shun Shibata, Hirotaka Hamada, Masatoshi Saito, Nobuo Yaegashi, Mikita Suyama, et al. CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 51. e2311372120
  • Kaela M Varberg, Esteban M Dominguez, Boryana Koseva, Joseph M Varberg, Ross P McNally, Ayelen Moreno-Irusta, Emily R Wesley, Khursheed Iqbal, Warren A Cheung, Carl Schwendinger-Schreck, et al. Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape. Nature communications. 2023. 14. 1. 4826-4826
  • Jennifer M Frost, Samuele M Amante, Hiroaki Okae, Eleri M Jones, Brogan Ashley, Rohan M Lewis, Jane K Cleal, Matthew P Caley, Takahiro Arima, Tania Maffucci, et al. Regulation of human trophoblast gene expression by endogenous retroviruses. Nature structural & molecular biology. 2023. 30. 4. 527-538
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MISC (31)：
  • Frontiers in the development of human embryo implantation models. 2024
  • 岡江寛明. Investigation of human early development using trophoblast stem cells. 実験医学. 2024. 42. 9
  • 柴田 峻, 遠藤 俊, Nagai Luis Augusto Eijy, 中戸 隆一郎, 岡江 寛明, 有馬 隆博. 新たな子宮内膜オルガノイドの確立とヒト胚着床の模倣. 日本内分泌学会雑誌. 2024. 99. 5. 1548-1548
  • 柴田 峻, 小林 記緒, 岡江 寛明, 有馬 隆博. 特集 ヒトの再生をめぐる諸問題 胎盤発生と細胞運命決定機構. HORMONE FRONTIER IN GYNECOLOGY. 2023. 30. 1. 29-36
  • 岡江寛明. 遺伝子からひも解くヒトとマウス胎盤の対応関係. 日本生殖医学会雑誌. 2023. 68. 4
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Patents (7)：
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Lectures and oral presentations  (40)：
  • 幹細胞を用いたヒト初期発生の理解
    (文部科学省と国立大学附置研究所・センター 個別定例ランチミーティング 2024)
  • Human trophoblast stem cells: a powerful tool for studying placental development, function, and disease
    (Centre for Trophoblast Research Annual Meeting (UK) 2024)
  • ヒト栄養膜幹細胞を用いた胎盤研究
    (第4回 有性生殖学会 2024)
  • ヒトとマウス胎盤の対応関係の理解
    (新学術・全能性 第5回公開シンポジウム 2023)
  • 遺伝子からひも解くヒトとマウス胎盤の対応関係
    (第68回日本生殖医学会学術講演会 2023)
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Education (2)：
  • 2004 - 2010 The University of Tokyo Graduate School of Science
  • 2000 - 2004 The University of Tokyo Faculty of Science
Professional career (1)：
  • Doctor of Science (The University of Tokyo)
Work history (2)：
  • 2023/01 - 現在 Kumamoto University Institute of Molecular Embryology and Genetics
  • 2010/04 - 2022/12 Tohoku University Graduate School of Medicine
Awards (4)：
  • 2020 - 東北大学大学院教育貢献賞
  • 2017 - 宮城県医師会医学奨励賞
  • 2017 - 東北大学医学部奨学賞(銀賞)
  • 2014 - 東北大学医学部産婦人科最優秀論文賞
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