Rchr
J-GLOBAL ID：201401043600576185   Update date: Nov. 30, 2024

Ono Koh

オノ コウ | Ono Koh
Affiliation and department：
Kyoto University Graduate School of Medicine

About Kyoto University Graduate School of Medicine


Job title： Professor
Research field  (1)： Cardiology
Research theme for competitive and other funds  (26)：
  • 2023 - 2026 Elucidation of the pathophysiology of aortic aneurysms and development of novel therapeutic agents to inhibit their progression and promote their regression
  • 2020 - 2023 Elucidation of the functions of long non-coding RNA in cardiovascular diseases
  • 2020 - 2022 Development of a novel therapeutic drug for the treatment of heart failure by cell protection
  • 2017 - 2020 Elucidation of global metabolic control mechanisms by microRNA-33a/b and development of specific regulatory strategy using artificial nucleic acid
  • 2017 - 2019 Development of novel immune checkpoint inhibitor therapy by microRNAs
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Papers (585)：
  • Yasuaki Takeji, Tomohiko Taniguchi, Takeshi Morimoto, Shinichi Shirai, Takeshi Kitai, Hiroyuki Tabata, Nobuhisa Ohno, Ryosuke Murai, Kohei Osakada, Koichiro Murata, et al. Availability of transcatheter aortic valve implantation across hospitals and differences in strategies and clinical outcomes in patients with severe aortic stenosis. Cardiovascular intervention and therapeutics. 2024
  • Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Ryuki Chatani, Tatsuhiro Shibata, Yuji Nishimoto, Yoshito Ogihara, Kosuke Doi, Maki Oi, et al. Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial). Circulation. 2024
  • Yuki Obayashi, Masahiro Natsuaki, Hirotoshi Watanabe, Takeshi Morimoto, Ko Yamamoto, Ryusuke Nishikawa, Akiyoshi Miyazawa, Nobuaki Suzuki, Satoru Suwa, Hidekuni Kirigaya, et al. An aspirin-free strategy and optical coherence tomography observations after percutaneous coronary intervention: Insights from the STOPDAPT-3 trial. Journal of cardiology. 2024. 84. 5. 342-344
  • Ko Yamamoto, Masahiro Natsuaki, Hirotoshi Watanabe, Takeshi Morimoto, Yuki Obayashi, Ryusuke Nishikawa, Kenji Ando, Satoru Suwa, Tsuyoshi Isawa, Hiroyuki Takenaka, et al. An aspirin-free strategy for percutaneous coronary intervention in patients with diabetes: a pre-specified subgroup analysis of the STOPDAPT-3 trial. European heart journal. Cardiovascular pharmacotherapy. 2024
  • Kyohei Yamaji, Kenji Kanenawa, Toru Morofuji, Ryusuke Nishikawa, Kazuaki Imada, Hirohiko Kohjitani, Hiroki Watanabe, Junichi Tazaki, Masanori Taniwaki, Seiji Koga, et al. Serial Optical Coherence Tomography Assessment of Coronary Atherosclerosis and Long-Term Clinical Outcomes. Journal of the American Heart Association. 2024. e034458
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MISC (211)：
  • 糀谷泰彦, 糀谷泰彦, 糀谷泰彦, 山本絵里香, 内野詠一郎, 田中宗和, 瀬尾拓哉, 仲山加奈子, 高野橋健太, 尾野亘, et al. Post-discharge Use of Tolvaptan in Patients with Heart Failure as a Predictor of 2-year Rehospitalization: Explainable Artificial-Intelligence Based Study. 日本循環器学会学術集会(Web). 2024. 88th
  • 西脇修司, 井上智之, 森永晃史, 米田史哉, 田中宗和, 糀谷泰彦, 静田聡, 尾野亘. 洞不全症候群に対してリードレスペースメーカ植込み後,VVI作動時にショックとなった1例. 植込みデバイス関連冬季大会プログラム・抄録集(Web). 2024. 16th
  • 井上智之, 西脇修司, 森永晃史, 米田史哉, 田中宗和, 相澤卓範, 糀谷泰彦, 静田聡, 尾野亘. VF zoneでICD頻回作動する頻拍を心内電位解析からTypical AVNRTと推定できた1例. 植込みデバイス関連冬季大会プログラム・抄録集(Web). 2024. 16th
  • 井上智之, 喜多村恭平, 羽賀博典, 森永晃史, 米田史哉, 西脇修司, 田中宗和, 糀谷泰彦, 牧山武, 尾野亘, et al. 持続性心房細動に対するアブレーション中に大量の右左シャントによる低酸素血症で救命困難となった不整脈原性右室心筋症の1例. 日本心臓病学会学術集会(Web). 2023. 71st
  • 田中宗和, 静田聡, 井上智之, 森永晃史, 米田史哉, 西脇修司, 糀谷泰彦, 尾野亘. 上大静脈をtriggerとし冠状静脈洞とマーシャル静脈の分岐部をsubstrateとするAFを心内心電図より明瞭に同定できた1例. 日本不整脈心電学会カテーテルアブレーション関連大会(Web). 2023. 2023
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Patents (5)：
  • microRNA(miR)-33aおよびmiR-33bを個別に制御できる合成核酸医薬の開発と大動脈瘤に対する効果
  • 心筋細胞の保護用の医薬組成物
  • 遺伝性痙性対麻痺(Hereditary Spastic Paraplegia; HSP)SPG4に対するmicroRNA-33a抑制療法
  • TDP-43プロテノパシーの予防又は治療用組成物
  • マイクロRNA溶出型ステント及びそれを用いた管腔治療
Books (5)：
  • microRNA: Medical Evidence, Chapter 10 “microRNAs and Cardiovascular Remodeling”
    Springer 2015
  • microRNAs and Cardiovascular Remodeling.
    Adv Exp Med Biol. 2015
  • 「生活習慣病とmiRNA」
    羊土社 2015
  • 「代謝と循環器疾患に関わるmicroRNA」
    中外医学社 2014
  • MicroRNAs and cardiovascular diseases. In: Charles H. Lawrie (ed): MicroRNAs in Medicine
    Wiley Blackwell 2014
Lectures and oral presentations  (4)：
  • SREBF1/MicroRNA-33b axis exhibits potent effect on unstable atherosclerotic plaque formation in vivo.
    (XVIIIth International Symposium on Atherosclerosis 2018)
  • Roles of microRNAs in cardiovascular diseases
    (Tokyo RNA Club 23rd meeting 2017)
  • MicroRNA-33 Encoded by an Intron of Srebp2 Regulates HDL in Vivo
    (2011 AVDRC International Symposium, Intervention of Vascular Aging: New Frontiers 2011)
  • MicroRNA-33 Encoded by an Intron of Srebp2 Cooperates to Control HDL in Vivo
    (第75回 日本循環器学会プレナリーセッション 2011)
Professional career (1)：
  • 医学博士 (京都大学)
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