Oinuma Izumi

オイヌマイズミ | Oinuma Izumi

Affiliation and department：
Other affiliations (1)：

Kyoto University

Homepage URL (1)： https://nrid.nii.ac.jp/ja/nrid/1000040452297/

Research field (3)： Functional biochemistry , Neuroscience - general , Cell biology

Research keywords (21)： cell biology , CRISPR , genome editing , 前立腺癌 , インテグリン , Rho , 網膜色素変性症 , グリオーマ , 骨転移 , Metastatic tumor , Semaphorin , Biochemistry , Ras , Neuronal network , nerve regeneration , cancer , neuron , cytoskeleton , R-Ras , axon guidance , small GTPase

Research theme for competitive and other funds (13)：

2020 - 2023 Elucidation of R-Ras function as a signaling hub
2019 - 2021 Novel axonal guidance mechanism based on dynamic alternative splicing of an actin scaffold
2017 - 2020 Elucidation of the signal integration mechanism on R-Ras family small GTPase in axonal guidance
2017 - 2019 Spatio-temporal regulation of alternative splicing of an F-actin scaffold proteins during neuronal network formation
2014 - 2017 Axon regeneration in the central nervous system with a novel blocker for semaphorin

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Papers (23)：

Matsuda T, Oinuma I. Imaging endogenous synaptic proteins in primary neurons at single-cell resolution using CRISPR/Cas9. Molecular biology of the cell. 2019. 30. 22. 2838-2855
Matsuda T, Oinuma I. Optimized CRISPR/Cas9-mediated in vivo genome engineering applicable to monitoring dynamics of endogenous proteins in the mouse neural tissues. Scientific Reports. 2019. 2019. 9. 11309
Matsuda T, Namura A, Oinuma I, equal contribution. Dynamic spatiotemporal patterns of alternative splicing of an F-actin scaffold protein, afadin, during murine development. Gene. 2019. 689. 20. 56-68
Daiki Ohama, Takahiko Matsuda, Izumi Oinuma. Differential regional and subcellular localization patterns of afadin splice variants in the mouse central nervous system. Brain Research. 2018. 1692. 74-86
Oinuma I. [Signaling mechanism for axonal guidance factors, semaphorins]. Seikagaku. The Journal of Japanese Biochemical Society. 2015. 87. 4. 428-437

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MISC (9)：

Nariaki Iwasawa, Izumi Oinuma, Manabu Negishi. l-Afadin, an actin-binding protein, controls axon branching downstream of R-Ras in hippocampal neurons. NEUROSCIENCE RESEARCH. 2011. 71. E335-E336
Genichi Tasaka, Izumi Oinuma, Manabu Negishi. Lamellipodin, a novel effector of M-Ras, regulates dendrite development by reconstructing actin network. NEUROSCIENCE RESEARCH. 2011. 71. E132-E132
Integrin activation by small GTPase R-Ras. The Cell. 2010. 42. 3. 96-99
Izumi Oinuma, Manabu Negishi. Signal transductions of semaphorins for repulsion of axons and dendrites. NEUROSCIENCE RESEARCH. 2008. 61. S14-S14
Izumi Oinuma, Hiranori Katoh, Manabu Negishi. R-Ras controls axon specification upstream of GSK-3 beta through integrin-linked kinase. NEUROSCIENCE RESEARCH. 2007. 58. S202-S202

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Books (2)：

Semaphorin Receptors and Their Signaling.
Springer Japan 2015
ブレインサイエンスレビュー2010
クバプロ 2010

Lectures and oral presentations (18)：

アクチン足場分子の選択的スプライシングの時空間制御が担う脳梁軸索ガイダンスの新概念
(次世代脳2018 合同若手シンポジウム 2018)
脳梁軸索回路構築はセントラルドグマのレベルで規定される
(大阪大学蛋白質研究所セミナー「高次脳機能の神経回路機構」 2018)
神経発達を担うアクチン足場蛋白質の選択的スプライシングの時空間制御
(神経発達・再生研究会(生理学研究所研究会) 2018)
アクチン足場タンパク質のスプライシングの時空間制御が担う神経回路構築
(第91回日本生化学会大会 2018)
R-Ras small GTPase functions as a signaling hub that enables orchestral regulation of various cell functions
(FBS Colloquium-193 2018)

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Education (3)：

2004 - 2007 Kyoto University Graduate School of Life Science Ph.D.
2002 - 2004 Kyoto University Graduate School of Life Science M.S.
1998 - 2002 Kyoto University Pharmaceutical Sciences B.S.

Professional career (1)：

博士(生命科学) (京都大学)

Work history (8)：

2021/04 - 現在兵庫県立大学理学研究科生命理学専攻細胞機能学講座教授
2016/04 - 現在 Kyoto University iCeMS Adjunct Professor
2016/04 - 現在 University of Hyogo Cell and Molecular Biology, Graduate School of Biostudies Professor
2013/08 - 2016/03 Kyoto University iCeMS Assistant Professor
2011/12 - 2016/03 Kyoto University Graduate School of Pharmaceutical Sciences Assistant Professor

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Committee career (6)：

2019 - 現在日本細胞生物学会 Cell Structure and Function 誌 Associate Editor
2018 - 現在日本神経科学会プログラム委員
2016 - 現在日本生化学会評議員
2017/04 - 2018/03 日本細胞生物学会将来計画委員会
2009 - 2009 日本生化学会大会男女共同参画フォーラム企画委員

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Awards (6)：

2018/07 - 新学術領域脳構築おける発生時計と場の連携第3回領域班会議優秀発表賞「神経回路構築におけるafadinの選択的スプライシングバリアントの発現タイミングの制御と意義」
2014/09 - 日本生化学会奨励賞「神経軸索ガイダンス分子セマフォリンの情報伝達機構」
2013/12 - 第5回井上リサーチアウォード「神経ガイダンスの分子基盤の解明-神経再生応用に向けて」
2013/06 - 花王研究奨励賞「神経軸索ガイダンス因子の情報伝達経路の解明」
2008/12 - 第24回井上研究奨励賞「神経軸索ガイダンス因子semaphorin受容体plexinの新規シグナル伝達機構の解明」

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Association Membership(s) (5)：

JAPAN SOCIETY FOR CELL BIOLOGY , ASCB (American Society for Cell Biology) , JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY , THE JAPAN NEUROSCIENCE SOCIETY , THE JAPANESE BIOCHEMICAL SOCIETY

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