Rchr
J-GLOBAL ID：201401046466257794   Update date: Sep. 29, 2024

Hisashi Doi

ドイ ヒサシ | Hisashi Doi
Affiliation and department：
Osaka Metropolitan University Organization for Research Promotion, Collaborative Research Center, Research Institute for Drug Discovery Science

About Osaka Metropolitan University Organization for Research Promotion, Collaborative Research Center, Research Institute for Drug Discovery Science


Job title： Specially Appointed Professor
Other affiliations (1)：
  • RIKEN  Center for Biosystems Dynamics Research, Laboratory for Chemical Biology   Visiting Scientist
Homepage URL  (1)： https://www.omu.ac.jp/orp/org/crc/drug_development/
Research field  (3)： Pharmaceuticals - chemistry and drug development ,  Synthetic organic chemistry ,  Chemical reaction and process system engineering
Research keywords  (10)： 11C ,  18F ,  脳神経 ,  アミノ酸 ,  生体分子 ,  標識化学 ,  合成化学 ,  生物活性有機化合物 ,  陽電子放射画像撮影法 ,  分子プローブ
Research theme for competitive and other funds  (10)：
  • 2024 - 2027 PETを用いた肝疾患病態におけるmRNA内封脂質ナノ粒子の動態-遺伝子発現相関研究
  • 2020 - 2023 Development of SN-38 derivatives with antitumor activity toward theranostics
  • 2015 - 2018 Construction of microcirculation and imaging evaluation method in intractable disease
  • 2013 - 2016 Development of PET probes of neuroprotective molecular components in oriental medicines
  • 2013 - 2016 Development of poorly water-soluble drug encapsulated protein nanocapsule possessing cancer directivity and application to DDS
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Papers (114)：
  • Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe. In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters. EJNMMI research. 2023. 13. 1. 36-36
  • Tsuyoshi Tahara, Shuhei Takatani, Mieko Tsuji, Nina Shibata, Nami Hosaka, Michiko Inoue, Masahiro Ohno, Daiki Ozaki, Aya Mawatari, Yasuyoshi Watanabe, et al. Characteristic Evaluation of a 11C-Labeled Leucine Analog, l-α-[5-11C]methylleucine, as a Tracer for Brain Tumor Imaging by Positron Emission Tomography. Molecular pharmaceutics. 2023. 20. 3. 1842-1849
  • Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, Nina Shibata, William E Hume, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe. Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response. Scientific reports. 2023. 13. 1. 1961-1961
  • Danxi Li, Di Hu, Yuta Ochi, Wakiko Arakaki, Aya Mawatari, Mika Shigeta, Yuping Wu, Emi Hayashinaka, Hiroyuki Neyama, Tsuyoshi Tahara, et al. Regional neuroinflammation induced by peripheral infection contributes to fatigue-like symptoms: a [18F]DPA-714 positron emission tomography study in rats. Frontiers in immunology. 2023. 14. 1261256-1261256
  • Miho Shukuri, Aya Mawatari, Shuhei Takatani, Tsuyoshi Tahara, Michiko Inoue, Wakiko Arakaki, Masahiro Ohno, Hisashi Doi, Hirotaka Onoe. Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2022. 63. 11. 1761-1767
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MISC (27)：
  • 越智祐太, 新垣和貴子, 胡迪, 李丹渓, 重田美香, 林中恵美, 和田康弘, 土居久志, 渡辺恭良, 崔翼龍. 擬似ウイルス感染モデルラットでの脳内炎症は倦怠感の惹起に関わる. 日本神経化学会大会抄録集(Web). 2022. 65th
  • 野崎 聡, 笹野 有未, 山本 憲一郎, 馬渡 彩, 柴田 仁奈, 中谷 友香, 尾上 嘉代, 和田 康弘, 露口 尚弘, 土居 久志, et al. バイオイメージングの創薬、診断、治療への展開 がんと炎症の差別化イメージング. 日本癌学会総会記事. 2017. 76回. S15-4
  • 馬渡 彩, 野崎 聡, 二宮 伸二, 渡辺 恭良, 土居 久志. チアミンおよびフルスルチアミンの11C-標識PETプローブの合成. ビタミン = Vitamins. 2017. 91. 3. 190-192
  • 大西 章仁, 千田 道雄, 赤松 剛, 相田 一樹, 佐々木 將博, 山本 泰司, 馬渡 彩, 宿里 充穂, 土居 久志, 渡辺 恭良, et al. 11C-ケトプロフェンメチルエステルS体の生体内分布と被ばく線量評価. 核医学. 2015. 52. 3. 269-269
  • H. Onoe, H. Yamanaka, C. Yokoyama, H. Mizuma, S. J. Finnema, H. Doi, C. Halldin. Increase in 5-HT1B receptors in nucleus accumbens and ventral pallidum by ketamine as its possible mechanism of antidepressant action: PET study with rhesus monkeys. European Journal of Nuclear Medicine and Molecular Imaging. 2014. 41. S215-S215
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Professional career (1)：
  • 博士(理学) (名古屋大学)
Work history (11)：
  • 2023/04 - 現在 RIKEN Center for Biosystems Dynamics Research, Laboratory for Chemical Biology Visiting Scientist
  • 2023/04 - 現在 Osaka Metropolitan University Organization for Research Promotion, Collaborative Research Center, Research Institute for Drug Discovery Science Specially Appointed Professor
  • 2018/04 - 2023/03 RIKEN Center for Biosystems Dynamics Research, Laboratory for Labeling Chemistry Team Leader
  • 2013/04 - 2018/03 RIKEN RIKEN Center for Life Science Technologies, Labeling Chemistry Team Team Leader
  • 2009/04 - 2013/03 RIKEN Center for Molecular Imaging Science, Molecular Imaging Labeling Chemistry Team Team Leader
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