Nakayama Kazuhisa

Affiliation and department：
Homepage URL (1)： http://www.pharm.kyoto-u.ac.jp//physchem/

Research field (1)： Cell biology

Research theme for competitive and other funds (24)：

2019 - 2024 Relationship between architecture and function of intraciliary protein trafficking complex: molecular basis for ciliopathies
2020 - 2022 Architecture of the transition zone separating the cytoplasm and cilioplasmand, and selective protein translocation across it
2015 - 2018 Regulation of vesicular trafficking by tethering complex and SNARE proteins
2015 - 2017 タンパク質間相互作用解析とイメージングに基づく繊毛形成と繊毛内輸送機構の解明
2015 - 2017 Development of high-throughput system of visible immunoprecipitation assay

2013 - 2015 生細胞でのイメージングを基盤とするシリアの形成とタンパク質輸送機構の解明

2010 - 2012 Coupling of membrane traffic and cytoskeleton remodeling in the regulation of cell motility

2009 - 2010 ARF-COPI輸送系が関与する新たな細胞機能の解析

2008 - 2009 細胞質分裂の調節における低分子量GTPaseとそのエフェクターの役割

2006 - 2008 Regulation of membrane traffic and ubiquitination by small GTPases

2003 - 2008 「メンブレントラフィック-分子機構から高次機能への展開」の取りまとめ

2003 - 2007 ゴルジ体を中心とするメンブレントラフィックの制御機構

2003 - 2005 Roles of multifunctional adaptor proteins, GGAs, in membrane traffic

2004 - 2004 ARFおよびARLの活性化定量法および細胞内局在決定法の開発

2003 - 2003 活性型ARFの定量法および細胞内局在決定法の開発

2001 - 2002 軸索伸長におけるRho-mDiaを介する低分子量G蛋白質間の協調作用の解明

2001 - 2001 低分子量GTP結合蛋白質ARFの活性型の定量法の開発

2001 - 2001 細胞運動およびがん化におけるRho-mDia-Src系の機能と作用機構の解明

1998 - 2001 Roles of clathrin-adaptor-like proteins in intracellular protein traffic.

1997 - 2000 ROLES OF GTP-BINDING PROTEINS IN THE FORMATION OF INTRACELLULAR TRANSPORT VESICLES

1996 - 1996 細胞内小胞輸送における低分子量GTP結合蛋白質および3量体G蛋白質の役割

1994 - 1995 Studies on Processing Endoproteases of Biologically Active Peptide Precursors

1989 - 1992 Structure and function of renin and prorenin.

1988 - 1990 新しいペプチドないしタンパク性神経作動因子の研究

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Papers (228)：

Asuka Hamamoto, Natsuki Kita, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin. Lysosomal membrane integrity in fibroblasts derived from patients with Gaucher disease. Cell Structure and Function. 2024. 49. 1. 1-10
Koshi Tasaki, Zhuang Zhou, Yamato Ishida, Yohei Katoh, Kazuhisa Nakayama. Compound heterozygous IFT81 variations in a skeletal ciliopathy patient cause Bardet-Biedl syndrome-like ciliary defects. Human molecular genetics. 2023. 32. 2887-2900
Yumeka Muranaka, Ryo Shigetomi, Yugo Iwasaki, Asuka Hamamoto, Kazuhisa Nakayama, Hiroyuki Takatsu, Hye-Won Shin. Novel phosphatidylinositol flippases contribute to phosphoinositide homeostasis in the plasma membrane. 2023
Shunya Hiyamizu, Hantian Qiu, Yuta Tsurumi, Yuki Hamada, Yohei Katoh, Kazuhisa Nakayama. Dynein-2-driven intraciliary retrograde trafficking indirectly requires multiple interactions of IFT54 in the IFT-B complex with the dynein-2 complex. Biology Open. 2023
Shunya Hiyamizu, Hantian Qiu, Laura Vuolo, Nicola L Stevenson, Caroline Shak, Kate J Heesom, Yuki Hamada, Yuta Tsurumi, Shuhei Chiba, Yohei Katoh, et al. Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective intraflagellar transport. Journal of Cell Science. 2023. 136. 5

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MISC (48)：

千葉秀平, 加藤洋平, 中山和久. Imaging of cilia and centrosome by Expansion Microscopy. Bio Clinica. 2022. 37. 11
加藤洋平, 千葉秀平, 中山和久. Observation of primary cilia and centrioles by expansion microscopy. 実験医学. 2022. 40. 16
加藤洋平, 千葉秀平, 中山和久. Superresolution imaging of primary cilia by expansion microscopy using an amplibody for fluorescence signal amplification. 生化学. 2022. 94. 4
中山和久, 加藤洋平, 千葉秀平. 繊毛形成と繊毛内タンパク質輸送の分子基盤. 日本生化学会大会(Web). 2021. 94th
千葉秀平, 加藤洋平, 中山和久. Super-resolution imaging of structure and assembly mechanism of the ciliary transition zone in mammalian cells. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

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Books (11)：

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Lectures and oral presentations (20)：

繊毛内タンパク質輸送複合体の構築様式と機能.
(第41回蛋白質の酵素の構造と機能に関する九州シンポジウム 2016)
Trafficking Machineries within Cilia: Arc hitectures and Functions of the IFT-A and IFT-B complexes.
(68回日本細胞生物学会大会シンポジウム「高次生命機能を司るメンブレントラフィック:分子基盤からその破綻による疾患発症の理解に向けて」 2016)
Regulation of cell division by membrane traffic involving Rab and Arf families of small GTPases
(International Symposium: Epigenetic Landscape in Biological Rhythms, “RNA and Clock” 2015)
Architecture of multi-subunit complexes involved in membrane trafficking revealed by visible immunopreci pitation (VIP) assay.
(The 18th iCeMS International Symposium/The 15th International Membrane Research Forum. 2015)
メンブレントラフィックと連動する動物細胞の細胞質分裂
(第66回日本細胞生物学会大会シンポジウム 2014)

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Education (3)：

Professional career (1)：

Work history (4)：

2003/05 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Professor
2002/04 - 2003/04 Kanazawa University Faculty of Pharmaceutical Sciences Professor
1994/01 - 2002/03 University of Tsukuba Institute of Biological Sciences Associate Professor
1987/04 - 1994/01 University of Tsukuba Institute of Biological Sciences Assistant Professor

Awards (5)：

2017 - 日本生化学会 JB論文賞 Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis. (2016) J. Biochem., 159, 201-208.
2013/10 - Best Teacher Award
2013 - 日本細胞生物学会 CSF Award Mitosis-Coupled, Microtubule-Dependent Clustering of Endosomal Vesicles around Centrosomes. (2013) Cell Struct. Funct., 38, 31-41.
2001 - 日本生化学会 JB論文賞 Identification and characterization of novel isoforms of COP I subunits. (2000) J. Biochem., 128, 793-801.
1994 - 日本生化学会日本生化学会奨励賞生理活性ペプチドおよびタンパク質前駆体のプロセシング酵素に関する研究

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