Ohta Hiroshi

Affiliation and department：

Research field (1)： Developmental biology

Research theme for competitive and other funds (8)：

2023 - 2027 ヒト卵原細胞から卵子への試験管内誘導系の確立
2020 - 2025 Elucidation of the gene expression cascade responsible for male sexuality and acquisition of fertility
2020 - 2023 試験管内において卵子形成の支持が可能な卵巣体細胞の新規培養法の確立
2019 - 2023 Establishment of culture system for inducing oocytes from primordial germ cell-like cells
2015 - 2019 Analysis of proliferation and differentiation of primordial germ cell-like cells derived from ES cells

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Papers (88)：

Kenta Murakami, Nobuhiko Hamazaki, Norio Hamada, Go Nagamatsu, Ikuhiro Okamoto, Hiroshi Ohta, Yoshiaki Nosaka, Yukiko Ishikura, Tomoya S Kitajima, Yuichiro Semba, et al. Generation of functional oocytes from male mice in vitro. Nature. 2023. 615. 7954. 900-906
Yukiko Ishikura, Hiroshi Ohta, Masahiro Nagano, Mitinori Saitou. Optimized protocol to derive germline stem-cell-like cells from mouse pluripotent stem cells. STAR protocols. 2022. 3. 3. 101544-101544
Ken Mizuta, Yoshitaka Katou, Baku Nakakita, Aoi Kishine, Yoshiaki Nosaka, Saki Saito, Chizuru Iwatani, Hideaki Tsuchiya, Ikuo Kawamoto, Masataka Nakaya, et al. Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys. The EMBO Journal. 2022. 41. 18
Masahiro Nagano, Bo Hu, Shihori Yokobayashi, Akitoshi Yamamura, Fumiya Umemura, Mariel Coradin, Hiroshi Ohta, Yukihiro Yabuta, Yukiko Ishikura, Ikuhiro Okamoto, et al. Nucleome programming is required for the foundation of totipotency in mammalian germline development. The EMBO Journal. 2022. 41. 13
Yukiko Ishikura, Hiroshi Ohta, Takuya Sato, Yusuke Murase, Yukihiro Yabuta, Yoji Kojima, Chika Yamashiro, Tomonori Nakamura, Takuya Yamamoto, Takehiko Ogawa, et al. In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells. Cell stem cell. 2021

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MISC (2)：

水谷英二, 岸上哲士, NGUYEN Van Thuan, 大田浩, 引地貴亮, BUI Hong Thuy, 若山清香, 若山照彦. 核移植胚への同一ntES細胞注入によるクローン作出効率改善の試み. J Reprod Dev. 2006. 52. Supplement. J119
若山清香, 岸上哲士, 坂出裕子, NGUYEN Van Thuan, 大田浩, 引地貴亮, 水谷英二, BUI Hong Thuy, 若山照彦. 極体および初期胚割球からのES細胞樹立の試み. J Reprod Dev. 2006. 52. Supplement. J125

Work history (8)：

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