2020 - 真菌の一酸化窒素耐性に関与する酵素GTP cyclohydrolase II を標的とした新規抗生物質の探索と開発
2016 - 2019 Synthetic regulatory mechanism and physiological function of nitric oxidce in yeasts and fungi in
2015 - 2019 Screening, identification, and functional analyses of protein denitrase
2013 - 2016 Synthetic mechanism and physiological role of nitric oxidce in yeasts
2013 - 2016 New regulatory mechanism of intracellular antioxidative system by the yeast acetyltransferase Mpr1
2016 - 酵母のN-アセチルトランスフェラーゼMpr1依存的な新規アルギニン代謝制御機構の解析
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Papers (27):
Seiya Shino, Ryo Nasuno, Hiroshi Takagi. S-glutathionylation of fructose-1,6-bisphosphate aldolase confers nitrosative stress tolerance on yeast cells via a metabolic switch. Free radical biology & medicine. 2022. 193. Pt 1. 319-329
Sayoko Oiki, Ryo Nasuno, Syun-Ichi Urayama, Hiroshi Takagi, Daisuke Hagiwara. Intracellular production of reactive oxygen species and a DAF-FM-related compound in Aspergillus fumigatus in response to antifungal agent exposure. Scientific reports. 2022. 12. 1. 13516-13516
Ryo Nasuno, Yuki Yoshikawa, Hiroshi Takagi. Acetaldehyde reacts with a fluorescent nitric oxide probe harboring an o-phenylenediamine structure that interferes with fluorometry. Free radical biology & medicine. 2022. 187. 29-37
Ryo Nasuno, Nozomi Iwai, Hiroshi Takagi. Development of a microtiter plate-based analysis method of nitric oxide dioxygenase activity. The Journal of general and applied microbiology. 2022. 68. 1. 38-41
Supapid Eknikom, Ryo Nasuno, Hiroshi Takagi. Molecular mechanism of ethanol fermentation inhibition via protein tyrosine nitration of pyruvate decarboxylase by reactive nitrogen species in yeast. Scientific reports. 2022. 12. 1. 4664-4664
Regulatory Mechanism of Nitric Oxide Synthesis and Its Physiological Function in Yeast : How to Use Nitric Oxide, Which Can Become both Medicine and Poison. 2017. 55. 9. 617-623
Yuki Yoshikawa, Ryo Nasuno, Hiroshi Takagi. Regulatory mechanism and physiological role of the flavoprotein Tah18-dependent Nitric Oxide synthesis in yeast. YEAST. 2015. 32. S131-S132
Ryo Nasuno, Hiroshi Takagi. Nitric oxide-mediated antioxidative mechanism in yeast: The transcription factor Mac1-dependent activation of the superoxide dismutase Sod1. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 2014. 42. 134-135
Education (3):
2010 - 2013 Nara Institute of Science and Technology Graduate School of Biological Sciences
2008 - 2010 Nara Institute of Science and Technology Graduate School of Biological Sciences
2003 - 2006 Showa University School of Pharmacy Division of Pharmacology
Professional career (1):
博士 (奈良先端科学技術大学院大学)
Work history (8):
2023/04 - 現在 Kobe University Engineering Biology Research Center Associate Professor
2018/04 - 2023/03 Nara Institute of Science and Technology
2017/04 - 2018/03 Cleveland Clinic Lerner Research Institute PostDoc
2016/05 - 2018/03 Nara Institute of Science and Technology Graduate School of Biological Sciences
2013/07 - 2016/04 Nara Institute of Science and Technology Graduate School of Biological Sciences
2013/04 - 2013/06 Nara Institute of Science and Technology Graduate School of Biological Sciences
2017/07 - The Japanese Biochemical Society JB Award Structure-based molecular design for thermostabilization of N-acetyltransferase Mpr1 involved in a novel pathway of L-arginine synthesis in yeast