Takashi Sekiya

セキヤタカシ | Takashi Sekiya

Affiliation and department：
Homepage URL (1)： http://kaken.nii.ac.jp/d/r/80519207.ja.html

Research field (2)： Medical biochemistry , Immunology

Research keywords (7)：細胞分化 , 自己免疫疾患 , 免疫学 , アレルギー , 炎症性疾患 , 制御性T細胞 , CD4T細胞

Research theme for competitive and other funds (10)：

2021 - 2024 エンハンサーによる多次元的制御能を標的としたCTL賦活化リプログラミング
2021 - 2023 ナイーブT細胞不均一性の形成メカニズムと意義の追求
2020 - 2022 IBD発症過程で生じるTh/Treg imbalanceの動態解析
2019 - 2021 CD4T細胞による「セルフ」の攻撃に作用する「ネオセルフ」抗原刺激の追求
2018 - 2021 Development of the novel screening method for reprogramming of inflammatory environment

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Papers (42)：

Takashi Sekiya, Shinya Hidano, Satoshi Takaki. Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells. Cell Reports. 2024. 43. 3. 113954-113954
Iwasaki Kenta, Tomosugi Toshihide, Sekiya Takashi, Sakamoto Shintaro, Miwa Yuko, Okada Manabu, Hiramitsu Takahisa, Goto Norihiko, Narumi Shunji, Watarai Yoshihiko, et al. Estimation of Sensitization Status in Renal Transplant Recipients by Assessing Indirect Pathway CD4+ T Cell Response to Donor Cell-pulsed Dendritic Cell. Transplantation. 2023. 107. 5. 1079-1088
Takashi Sekiya, Hidenori Kasahara, Ryo Takemura, Shinya Fujita, Jun Kato, Noriko Doki, Yuta Katayama, Yukiyasu Ozawa, Satoru Takada, Tetsuya Eto, et al. Essential Roles of the Transcription Factor NR4A1 in Regulatory T Cell Differentiation under the Influence of Immunosuppressants. The Journal of Immunology. 2022. 208. 9. 2122-2130
Takashi Sekiya. Comparison Between Nr4a Transcription Factor Regulation and Function in Lymphoid and Tumor Treg Cells. Frontiers in Immunology. 2022. 13. 866339
Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki. Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021. 24. 3. 102166-102166

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MISC (4)：

T. Kondo, R. Morita, Y. Kassai, T. Sekiya, S. Chikuma, Y. Gotou, M. Kanamori, T. Miyazaki, M. Kubo, A. Yoshimura. Reprogramming of T cells from effector to stem cell memory by Notch signaling. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 986-986
Induction mechanism of Foxp3 by NR4a nuclear receptors and TGF-β. 2013. 246. 10. 823-830
Induction mechanism of Foxp3 by NR4a2. 2012. 57. 4. 360-366
関谷高史, 足達俊吾, 河府和義, 山田達也, 古川洋一, 中村祐輔, 田代康介, 久原哲, 大和田進. β-cateninによるTGF-βシグナル伝達系路の制御. 日本分子生物学会年会プログラム・講演要旨集. 2003. 26th. 774

Patents (1)：

Books (8)：

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Lectures and oral presentations (25)：

免疫抑制剤存在下でのTreg分化における転写因子NR4A1の役割
(第20回日本免疫治療学会学術集会 2023)
Tonic TCR and IL-1b signaling mediate momentary and durable phenotypic alterations in naive CD4+ T cells
(2022)
Roles of the nuclear orphan receptor Nr4a in Th/Treg differentiation and in regulation of allergic asthma pathogenesis
(The 17th International Congress of Immunology 2019)
制御性T細胞移入療法の進歩を導く基礎研究の現在
(第55回日本移植学会総会 2019)
制御性T細胞の分化と維持の分子機構〜移植免疫における炎症環境とCNIの作用を中心に〜
(第18回広島臓器移植セミナー 2019)

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Education (2)：

Professional career (1)：

Work history (4)：

Awards (1)：

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