Rchr
J-GLOBAL ID：201401070104149720   Update date: Dec. 11, 2025

Takashi Sekiya

セキヤ タカシ | Takashi Sekiya
Affiliation and department：
National Center for Global Health and Medicine

About National Center for Global Health and Medicine


Homepage URL  (1)： http://kaken.nii.ac.jp/d/r/80519207.ja.html
Research field  (2)： Medical biochemistry ,  Immunology
Research keywords  (7)： 細胞分化 ,  自己免疫疾患 ,  免疫学 ,  アレルギー ,  炎症性疾患 ,  制御性T細胞 ,  CD4T細胞
Research theme for competitive and other funds  (11)：
  • 2023 - 2027 ナイーブT細胞の不均一性に着目した組織特異的免疫応答の解明および免疫制御法の開発
  • 2021 - 2024 エンハンサーによる多次元的制御能を標的としたCTL賦活化リプログラミング
  • 2021 - 2023 ナイーブT細胞不均一性の形成メカニズムと意義の追求
  • 2020 - 2022 IBD発症過程で生じるTh/Treg imbalanceの動態解析
  • 2019 - 2021 CD4T細胞による「セルフ」の攻撃に作用する「ネオセルフ」抗原刺激の追求
Show all
Papers (42)：
  • Takashi Sekiya, Shinya Hidano, Satoshi Takaki. Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells. Cell Reports. 2024. 43. 3. 113954-113954
  • Iwasaki Kenta, Tomosugi Toshihide, Sekiya Takashi, Sakamoto Shintaro, Miwa Yuko, Okada Manabu, Hiramitsu Takahisa, Goto Norihiko, Narumi Shunji, Watarai Yoshihiko, et al. Estimation of Sensitization Status in Renal Transplant Recipients by Assessing Indirect Pathway CD4+ T Cell Response to Donor Cell-pulsed Dendritic Cell. Transplantation. 2023. 107. 5. 1079-1088
  • Takashi Sekiya, Hidenori Kasahara, Ryo Takemura, Shinya Fujita, Jun Kato, Noriko Doki, Yuta Katayama, Yukiyasu Ozawa, Satoru Takada, Tetsuya Eto, et al. Essential Roles of the Transcription Factor NR4A1 in Regulatory T Cell Differentiation under the Influence of Immunosuppressants. The Journal of Immunology. 2022. 208. 9. 2122-2130
  • Takashi Sekiya. Comparison Between Nr4a Transcription Factor Regulation and Function in Lymphoid and Tumor Treg Cells. Frontiers in Immunology. 2022. 13. 866339
  • Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki. Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021. 24. 3. 102166-102166
ｍore...
MISC (4)：
Patents (1)：
  • 抗BAMBI抗体、及びそれを含有する大腸癌及び肝臓癌の診断剤又は治療剤
Books (9)：
  • Clinical Immunology & Allergology
    2025
  • Inflammation & Immunity
    2021
  • Clinical Immunology & Allergology
    2020
  • 医学のあゆみ 制御性T細胞研究の現在
    2019
  • The Epigenetics of Autoimmunity
    Elsevier 2018
ｍore...
Lectures and oral presentations  (28)：
  • Elucidation of atheroprotective function of peripheral blood Treg cells and its molecular and cellular basis
    (The 54th Annual Meeting of The Japanese Society for Immunology 2025)
  • Treg細胞の臨床応用に向けた新機軸: 免疫抑制剤下におけるTreg細胞分化の分子機序と末梢血中Treg細胞の性質と機能の解明
    (第61回 日本移植学会総会 2025)
  • Characterization of peripheral blood Treg cells
    (2024)
  • 免疫抑制剤存在下でのTreg分化における転写因子NR4A1の役割
    (第20回 日本免疫治療学会学術集会 2023)
  • Tonic TCR and IL-1b signaling mediate momentary and durable phenotypic alterations in naive CD4+ T cells
    (2022)
ｍore...
Education (2)：
  • 1999 - 2004 東京大学大学院 農学生命科学研究科 応用生命工学専攻
  • 1995 - 1999 The University of Tokyo
Professional career (1)：
  • 博士(農学) (東京大学)
Work history (4)：
  • 2016/11 - 現在 National Center for Global Health and Medicine Chief
  • 2014/04 - 2016/11 Keio University
  • 2008/08 - 2014/04 Keio University
  • 2004/04 - 2008/08 米国・Fox Chase Cancer Center ポスドク
Awards (1)：
  • JSI Young Investigator Award
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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