Kazuko Sakai

サカイカズコ | Kazuko Sakai

Homepage URL (1)： http://kaken.nii.ac.jp/d/r/20580559.ja.html

Research field (1)： Tumor diagnostics and therapeutics

Research theme for competitive and other funds (22)：

2024 - 2027 Evaluation of minimal residual disease in postoperative lung cancer using platelet RNA influenced by the tumor environment.
2023 - 2027 血中遊離核酸検査の質保証と技能試験の開発;精確な結果に基づくゲノム医療をめざして
2023 - 2027 血中遊離核酸検査の質保証と技能試験の開発;精確な結果に基づくゲノム医療をめざして
2023 - 2026 Validation study of a model for estimating the primary organ of cancer of unknown primary by methylation analysis of circulating tumor DNA
2023 - 2026 Validation study of a model to estimate the primary organ of cancer of unknown primary

2022 - 2025 直腸癌術後縫合不全発症における腸管免疫・腸内細菌を含む微小環境変化の解析

2020 - 2023 Functional analysis of novel responsible genes for methotrexate-related lymphoproliferative disease toward genomic medicine

2020 - 2023 To improve quality of cancer gene panel tests by strategic implementation of external quality assessment scheme

2020 - 2023 Establishment of aminoacid transporter directed prostate cancer therapy based on the liquid biopsy

2018 - 2023 Development of new treatment for ovarian cancer based on intratumor heterogeneity

2019 - 2022 Functional analysis of novel gene mutation identified in clinical sequencing

2019 - 2022 Investigation of molecular pathology based on quantitative evaluation of intratumor heterogeneity in hepatocellular carcinoma

2019 - 2022 Immune related gene-expression profiling for the combination of chemotherapy and PD-1/PD-L1 inhibition.

2018 - 2022 Development of minimally invasive treatment based on risk assessment for HPV-mediated oropharyngeal carcinomas

2017 - 2022 Chemical communication between human and microflora in inflammatory bowel disease, carcinogenesis, and cancer immunity

2017 - 2020 Investigation for a mechanism of cetuxifmab resistance in head and neck cancers

2016 - 2019 Detection of ALK fusion genes in plasma exosomes

2015 - 2018 Development of biomarkers for multimodality treatment aimed at function preservation in head and neck cancer

2014 - 2017 Exploratory analyses of immunohistochemistry pattern and genetic alterations for salivary gland cancer

2014 - 2016 Liquid biopsy for detection of somatic mutation using next generation sequencer

2012 - 2015 Multiplex molecular profiling in advanced non-small cell lung cancers

2012 - 2014 Detection of EML4-ALK in serum RNA from lung cancer patients

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Papers (234)：

Yoshiaki Nagatani, Naomi Kiyota, Yoshinori Imamura, Taiji Koyama, Yohei Funakoshi, Masato Komatsu, Tomoo Itoh, Masanori Teshima, Ken-Ichi Nibu, Kazuko Sakai, et al. Different characteristics of the tumor immune microenvironment among subtypes of salivary gland cancer. Asia-Pacific journal of clinical oncology. 2024
Yurie Kura, Marco A De Velasco, Kazuko Sakai, Hirotsugu Uemura, Kazutoshi Fujita, Kazuto Nishio. Exploring the relationship between ulcerative colitis, colorectal cancer, and prostate cancer. Human cell. 2024
Chisato Wakamori, Marco A De Velasco, Kazuko Sakai, Yurie Kura, Makoto Matsushita, Saizo Fujimoto, Koji Hatano, Norio Nonomura, Kazutoshi Fujita, Kazuto Nishio, et al. A cross-species analysis of fecal microbiomes in humans and mice reveals similarities and dissimilarities associated with prostate cancer risk. The Prostate. 2024
西尾和人, 坂井和子. 免疫チェックポイント阻害薬の効果と消化管免疫関連事象の関連性腸内細菌叢と宿主の全トランスクリプトームの統合的解析. 肺癌. 2024. 64. 3. 237-237
Tomoko Aoki, Naoshi Nishida, Yutaka Kurebayashi, Kazuko Sakai, Masahiro Morita, Hirokazu Chishina, Masahiro Takita, Satoru Hagiwara, Hiroshi Ida, Kazuomi Ueshima, et al. Two Distinct Characteristics of Immune Microenvironment in Human Hepatocellular Carcinoma with Wnt/β-Catenin Mutations. Liver cancer. 2024. 13. 3. 285-305

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MISC (420)：

西尾和人, 坂井和子. MRDは肺がん治療(オリゴ転移,周術期治療)を変えるか? リキッドバイオプシーによるMRD解析に用いられ得る技術. 肺癌. 2023. 63. 5. 371-371
庄田浩康, 池田慧, 坪井正博, 坂井和子, 三角俊裕, 赤松弘朗, 棚橋雅幸, 丹保裕一, 齋藤春洋, 豊岡伸一, et al. 完全切除後II-III期のEGFR変異陽性非小細胞肺癌に対する第III相IMPACT試験における付随バイオマーカー研究. 肺癌. 2023. 63. 5. 499-499
若森千怜, デベラスコ・マルコ, 倉由吏恵, 藤田和利, 坂井和子, 松下慎, 森康範, 野澤昌弘, 西本光寿, 吉村一宏, et al. ヒトおよびマウスの前立腺癌腸内細菌叢の包括的解析について(Integrative gut microbiome analysis of human and mouse prostate cancer). 日本癌学会総会記事. 2023. 82回. 71-71
植村天受, 倉由吏恵, 藤田和利, 坂井和子, シュラー・アルウイン, サッハセンマイヤー・クリス, 野澤昌弘, 吉村一宏, 西尾和人, デベラスコ・マルコ. 前立腺癌マウスにおける腫瘍浸潤ミエロイド細胞について(Targeting tumor immunosuppressive myeloid cells in mouse Pten-null prostate cancer). 日本癌学会総会記事. 2023. 82回. 408-408
金村宙昌, 竹原俊幸, 小野寺勇太, 寺村岳士, 鈴木慎一郎, 坂井和子, 西尾和人, 中川和彦, 林秀敏, 米阪仁雄. PTPRRを介したEGFR活性化に起因するKRASG12C阻害薬耐性の克服(Combating acquired resistance to KRAS inhibitors in NSCLC by targeting PTPRR-mediated activation of EGFR signaling). 日本癌学会総会記事. 2023. 82回. 422-422

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Lectures and oral presentations (105)：

HCC inflamed classにおける遺伝子変異の頻度と術後再発率に関する検討
(日本消化器病学会雑誌(Web) 2024)
MRDは肺がん治療(オリゴ転移,周術期治療)を変えるか? リキッドバイオプシーによるMRD解析に用いられ得る技術
(肺癌 2023)
完全切除後II-III期のEGFR変異陽性非小細胞肺癌に対する第III相IMPACT試験における付随バイオマーカー研究
(肺癌 2023)
妊孕性温存治療中BRAF融合型神経内分泌癌成分の転移が急速に進行した子宮内膜癌の1例
(日本癌治療学会学術集会抄録集 2023)
ヒトおよびマウスの前立腺癌腸内細菌叢の包括的解析について(Integrative gut microbiome analysis of human and mouse prostate cancer)
(日本癌学会総会記事 2023)

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Professional career (1)：

博士(理学) (お茶の水女子大学)

Work history (1)：

2012 - Kindai University Faculty of Medicine

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