Niwa Akira

Affiliation and department：

Research field (1)： Hematology and oncology

Research theme for competitive and other funds (9)：

2020 - 2023 新規Epo抵抗性因子の探索と分子機序の解明:赤芽球分化・増殖と脂質代謝の関連性
2017 - 2019 Development of bone-organod and its application for the research in bone diseases
2016 - 2019 Study on the clonal evolution of leukemia induced with internal mutators
2014 - 2017 Identification of causative genes for hemangioblastoma to elucidate the mechanisms of neovascularization and to develop novel therapeutic strategies
2014 - 2016 Induction and expansion of PSC-derived HSCs by manipulating culture microenvironment

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Papers (80)：

Jingxin Wang, Norikazu Saiki, Ayako Tanimura, Takafumi Noma, Akira Niwa, Tastutoshi Nakahata, Megumu K Saito. UK-5099, a mitochondrial pyruvate carrier inhibitor, recovers impaired neutrophil maturation caused by AK2 deficiency in human pluripotent stem cell models. Biochemical and biophysical research communications. 2023. 687. 149211-149211
Megumu K. Saito, Mitsujiro Osawa, Nao Tsuchida, Kotaro Shiraishi, Akira Niwa, Knut Woltjen, Isao Asaka, Katsuhisa Ogata, Suminobu Ito, Shuzo Kobayashi, et al. A disease-specific iPS cell resource for studying rare and intractable diseases. Inflammation and Regeneration. 2023. 43. 1
Naoya Kase, Yohko Kitagawa, Akihiro Ikenaka, Akira Niwa, Megumu K. Saito. A concise in vitro model for evaluating interactions between macrophage and skeletal muscle cells during muscle regeneration. Frontiers in Cell and Developmental Biology. 2023. 11
Akihiro Ikenaka, Yohko Kitagawa, Michiko Yoshida, Chuang-Yu Lin, Akira Niwa, Tatsutoshi Nakahata, Megumu K Saito. SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis. Life science alliance. 2023. 6. 3
Takahiro Hayashi, Naoko Yano, Kengo Kora, Atsushi Yokoyama, Kanako Maizuru, Taisei Kayaki, Kinuko Nishikawa, Mitsujiro Osawa, Akira Niwa, Toshiki Takenouchi, et al. Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy. Human molecular genetics. 2023. 32. 10. 1683-1697

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MISC (79)：

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Lectures and oral presentations (13)：

NK Cells from Human Pluripotent Stem Cells for Immunotherapy
(BLOOD 2018)
iPSC-Based Phenomic Screen Revealed an Impact of Uncontrolled NFkB Activity at the Initiating Stages of AML1-ETO Related Leukemia
(BLOOD 2018)
Identification of Candidate Progenitor Populations Which Causes Transient Abnormal Myelopoiesis
(BLOOD 2017)
Exogenously Added Cofilin Increases Ex Vivo Production of Functional Platelets By Stimulating Proplatelet Formation
(BLOOD 2017)
PSC-Derived Hematopoietic System to Elucidate the Cooperation Between Gene Alterations and Cell Lineages in Leukemogenesis
(BLOOD 2016)

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