Kobayashi Minoru

Affiliation and department：

Research field (1)： Cell biology

Research theme for competitive and other funds (12)：

2021 - 2024 がん個別化放射線治療法の確立に向けたTR研究
2021 - 2024 新規リアルタイムDNA損傷修復応答検出システムの構築と腫瘍内DNA損傷応答の解析
2021 - 2023 悪性固形腫瘍内低酸素がん細胞に対する血中マーカーのゲノムワイドスクリーニング
2019 - 2021 A novel invasion-related gene involved in tumor recurrence after radiation therapy
2018 - 2021 Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers

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Papers (39)：

Gouki Kambe, Minoru Kobayashi, Hiroshi Ishikita, Sho Koyasu, Ester M. Hammond, Hiroshi Harada. ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1. Biochemical and Biophysical Research Communications. 2024. 733. 150604-150604
Huiying Mu, Shuai Shao, Bingquan Wu, Koji Miki, Minoru Kobayashi, Hiroshi Harada, Kouichi Ohe. Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance. Sensors and Actuators B: Chemical. 2024. 413. 135876-135876
Iori Tamura, Daichi M. Sakamoto, Bo Yi, Yutaro Saito, Naoki Yamada, Jumpei Morimoto, Yoichi Takakusagi, Masafumi Kuroda, Shimpei I. Kubota, Hiroyuki Yatabe, et al. Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging. Science Advances. 2024. 10. 29
Lee PWT, Suwa T, Kobayashi M, Yang H, Koseki LR, Takeuchi S, Chow CCT, Takaaki Yasuhara, Hiroshi Harada. Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner. British journal of cancer. 2024
Peter W.T. LEE, Lina Rochelle Koseki, Takao Haitani, Hiroshi Harada, Minoru Kobayashi. Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells. Cancers. 2024

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MISC (9)：

小林稔, 平岡, 真寛, 原田浩. 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析. 2014
Minoru Kobayashi, Hiroshi Harada. [Hypoxic stress and HIF]. Seikagaku. The Journal of Japanese Biochemical Society. 2013. 85. 3. 187-195
小林稔, 曽麗華, 後藤容子, 井上実, 板坂聡, 吉村通央, 原田浩, 平岡真寛. IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する. 2013
Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells. 2013
KOBAYASHI Minoru, ASHINO Shigeru, SUZUKI Ikurou, KITAMURA Hidemitsu, YASUDA Kenji, NISHIMURA Takashi. Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation. 2011

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Lectures and oral presentations (22)：

Decreased expression levels of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase
(第18回がんとハイポキシア研究会 2022)
DNA double strand breaksのインビボ定量評価に向けたEGFP-53BP1ノックインマウスの樹立
(2019)
A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes
(2018)
HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating Shh.
(2018)
A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes
(The 17th International Joint Mini-Symposium on Molecular and Cell Biology 2018)

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