Motozono Chihiro

モトゾノチヒロ | Motozono Chihiro

Affiliation and department：

Research field (2)： Virology , Immunology

Research theme for competitive and other funds (8)：

2022 - 2025 Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivity
2021 - 2024 Development of HLA-independent T cell receptor-T cell therapy for innovative immunological cancer therapy
2023 - 2024 T cell receptor cross-reactivity and structural basis of virus immune escape
2019 - 2022 Immune regulation by sensing endogenous lipid composition changes via inhibitory C-type lectin receptor
2017 - 2019 Immune regulation by inhibitory immune receptors against Mycobacteria

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Papers (30)：

Isaac Ngare, Toong Seng Tan, Mako Toyoda, Takeo Kuwata, Soichiro Takahama, Eriko Nakashima, Naoya Yamasaki, Chihiro Motozono, Teruhisa Fujii, Rumi Minami, et al. Factors Associated with Neutralizing Antibody Responses following 2-Dose and 3rd Booster Monovalent COVID-19 Vaccination in Japanese People Living with HIV. Viruses. 2024. 16. 4
Hiroyasu Aoki, Masahiro Kitabatake, Haruka Abe, Peng Xu, Mikiya Tsunoda, Shigeyuki Shichino, Atsushi Hara, Noriko Ouji-Sageshima, Chihiro Motozono, Toshihiro Ito, et al. CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance. Cell reports. 2024. 43. 3. 113887-113887
Omnia Reda, Kazuaki Monde, Kenji Sugata, Akhinur Rahman, Wajihah Sakhor, Samiul Alam Rajib, Sharmin Nahar Sithi, Benjy Jek Yang Tan, Koki Niimura, Chihiro Motozono, et al. HIV-Tocky system to visualize proviral expression dynamics. Communications biology. 2024. 7. 1. 344-344
Yusuke Tomita, Shinya Sakata, Kosuke Imamura, Shinji Iyama, Takayuki Jodai, Koichi Saruwatari, Shohei Hamada, Kimitaka Akaike, Moriyasu Anai, Kazuaki Fukusima, et al. Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations. Cancers. 2023. 16. 1
Mako Toyoda, Toong Seng Tan, Chihiro Motozono, Godfrey Barabona, Akiko Yonekawa, Nobuyuki Shimono, Rumi Minami, Yoji Nagasaki, Yusuke Miyashita, Hiroyuki Oshiumi, et al. Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay. Microbiology spectrum. 2023. e0066023

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MISC (18)：

有津由樹, 北松瑞生, TAN Toong Seng, 上野貴将, 本園千尋. Evaluation of T cell antigen recognition for peptides introduced unnatural amino acids. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa. Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection. EUROPEAN JOURNAL OF IMMUNOLOGY. 2016. 46. 817-817
C. Motozono, J. S. Bridgeman, D. A. Price, A. K. Sewell, T. Ueno. Clonotypically similar hybrid alpha beta T cell receptors can exhibit markedly different surface expression, antigen specificity and cross-reactivity (vol 180, pg 560, 2015). CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016. 185. 1. 119-123
河原佐智代, 川崎ゆり, 本園千尋, 高村史記, 宮澤正顯. B細胞固有TLR7シグナル伝達はレトロウイルス感染後の組換えウイルス産生防止にとって必要である. 日本免疫学会総会・学術会記録. 2015. 44. 64
谷中冴子, 上野貴将, 本園千尋, 菅瀬謙治, 津本浩平. ヒト主要組織適合複合体の動的構造と傷害性T細胞の活性の関連について. 日本蛋白質科学会年会プログラム・要旨集. 2010. 10th

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Professional career (1)：

医学博士

Awards (2)：

2023 - 日本エイズ学会 ECC山口メモリアルエイズ研究奨励賞
2022 - 熊本大学令和4年度熊本大学研究業績表彰者

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