Takahashi Kazutoshi

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://kazutakahashi.cira.kyoto-u.ac.jp/

Research field (1)： Cell biology

Research keywords (7)： Reprogramming , Cell Fate , Pluripotency , Microprotein , Circular RNA , Translation , Stem Cell

Research theme for competitive and other funds (20)：

2024 - 2028 Elucidating the mechanism underlying pluripotency from the angle of cellular context-dependent translational regulation.
2020 - 2026 Expanded understanding of molecular mechanisms governing pluripotency by focusing on non-canonical translation.
2023 - 2024 機能スクリーニングとオミックス解析を用いた分化多能性を規定する翻訳制御機構の解明
2021 - 2024 環状RNAの翻訳機構を理解しその生理的意義を解明する
2022 - 2023 完全な翻訳地図と翻訳予測モデルによる細胞機能の理解

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Papers (74)：

Chikako Okubo, Michiko Nakamura, Masae Sato, Yuichi Shichino, Mari Mito, Yasuhiro Takashima, Shintaro Iwasaki, Kazutoshi Takahashi. Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency. bioRxiv. 2024
Renxing Yi, Rina Hashimoto, Ayaka Sakamoto, Yasufumi Matsumura, Miki Nagao, Kazutoshi Takahashi, Kazuo Takayama. Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection. iScience. 2022. 25. 11. 105427-105427
Akira Kunitomi, Ryoko Hirohata, Vanessa Arreola, Mitsujiro Osawa, Tomoaki M. Kato, Masaki Nomura, Jitsutaro Kawaguchi, Hiroto Hara, Kohji Kusano, Yasuhiro Takashima, et al. Improved Sendai viral system for reprogramming to naive pluripotency. Cell Reports Methods. 2022. 100317-100317
Mio Iwasaki, Yuka Kawahara, Chikako Okubo, Tatsuya Yamakawa, Michiko Nakamura, Tsuyoshi Tabata, Yohei Nishi, Megumi Narita, Akira Ohta, Hirohide Saito, et al. Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells. iScience. 2022. 25. 5. 104289-104289
Kazutoshi Takahashi, Chikako Okubo, Michiko Nakamura, Mio Iwasaki, Yuka Kawahara, Tsuyoshi Tabata, Yousuke Miyamoto, Knut Woltjen, Shinya Yamanaka. A stress-reduced passaging technique improves the viability of human pluripotent cells. Cell reports methods. 2022. 2. 2. 100155-100155

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MISC (122)：

高橋和利. iPS細胞までの道のり. 実験医学. 2020. 38. 8-13
個人の組織から分離された線維芽細胞及びそれらから作成されたiPS細胞のエピジェネティッククロック解析. Journal of Nagoya Women’s University. 2019. 65. 27-38
Karagiannis P, Takahashi K, Saito M, Yoshida Y, Okita K, Watanabe A, Inoue H, Yamashita JK, Todani M, Nakagawa M, et al. Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. Physiological reviews. 2019. 99. 1. 79-114
高橋和利, 山中伸弥. iPS細胞研究最前線. 先進医療NAVIGATOR「今日の再生医療・細胞医療の産業化に向けて」. 2017. 7-17
Takahashi, K, Yamanaka, S. A decade of transcription factor-mediated reprogramming to pluripotency. Nature Reviews Molecular Cell Biology. 2016. 17. 3. 183-193

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Books (1)：

Identification of genes involved in tumor-like properties of ES cells.
Embryonic Stem Cells-II : Methods and Protocols, in press

Lectures and oral presentations (97)：

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Professional career (1)：

Work history (10)：

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Awards (11)：

2020/02 - KODAMA国際教育財団未来のいしずえ賞
2013/09 - フロンティアサロン財団フロンティアサロン永瀬賞
2012/10 - 明日の象徴事務局明日の象徴
2012/10 - The New York Stem Cell Foundation The Robertson Stem Cell Prize
2011/06 - International Society for Stem Cell Research ISSCR McEwen Centre Award for Innovation

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