Rchr
J-GLOBAL ID：201401073899761214
Update date: Sep. 19, 2024
Yoshikawa Takeo
ヨシカワ タケオ | Yoshikawa Takeo
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://pharmacology1.med.hokudai.ac.jp/
Research field (1)：
Pharmacology
Research theme for competitive and other funds (13)：
- 2023 - 2027 中枢神経系脆弱性と全身麻酔に関連した周術期認知機能障害の神経病理解析
- 2022 - 2025 Elucidation of important research issues to be solved in pharmacological research on histamine
- 2021 - 2024 Analysis of heparanse in skeletal muscles
- 2020 - 2023 吸入麻酔薬の意識消失作用におけるニューロテンシン神経系の役割
- 2019 - 2022 Translational research of a 18F-labeled cation type myocardium perfusion imaging agent
- 2018 - 2021 Mechanism of histamine-induced aggresive behaviors in mice
- 2016 - 2018 Development of a novel labeling method for affibody by F-18 labeled amino acid and a cell-free protein synthesis system
- 2016 - 2018 Importance of histamine metabolizing enzyme in the brain
- 2014 - 2018 Analysis of histamine system through genetically modified mice
- 2014 - 2016 Analysis of plasma membrane monoamine transporter in brain
- 2014 - 2015 Molecular mechanism of brain histamine clearance
- 2012 - 2014 Generation of molecular imaging pharmacology using small primate mamosets
- 2009 - 2011 Integrated research of histamine system from molecular to wholeanimals and humans using leading-edge technologies
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Papers (98)：
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Kensuke Sakaji, Sara Ebrahimiazar, Yasuhiro Harigae, Kenichi Ishibashi, Takeya Sato, Takeo Yoshikawa, Gen-ichi Atsumi, Ching-Hwa Sung, Masaki Saito. MAST4 promotes primary ciliary resorption through phosphorylation of Tctex-1. Life Science Alliance. 2023. 6. 11. e202301947-e202301947
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Nami Tateyama, Teizo Asano, Tomohiro Tanaka, Yu Isoda, Yuki Okada, Hiyori Kobayashi, Guanjie Li, Ren Nanamiya, Takeo Yoshikawa, Mika K Kaneko, et al. Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies (C3Mab-6 and C3Mab-7). Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023. 42. 2. 68-72
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Yu Isoda, Tomohiro Tanaka, Hiroyuki Suzuki, Teizo Asano, Kaishi Kitamura, Yuma Kudo, Ryo Ejima, Kazuki Ozawa, Takeo Yoshikawa, Mika K Kaneko, et al. Epitope Mapping of the Novel Anti-Human CCR9 Monoclonal Antibody (C9Mab-11) by 2 × Alanine Scanning. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023. 42. 2. 73-76
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Guanjie Li, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Takeo Yoshikawa, Mika K Kaneko, Yukinari Kato. Epitope Mapping of an Anti-EpCAM Monoclonal Antibody (EpMab-37) Using the Alanine Scanning Method. Monoclonal antibodies in immunodiagnosis and immunotherapy. 2023. 42. 1. 41-47
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Guanjie Li, Hiroyuki Suzuki, Tomokazu Ohishi, Teizo Asano, Tomohiro Tanaka, Miyuki Yanaka, Takuro Nakamura, Takeo Yoshikawa, Manabu Kawada, Mika Kaneko, et al. Antitumor activities of a defucosylated anti-EpCAM monoclonal antibody in colorectal carcinoma xenograft models. International Journal of Molecular Medicine. 2023. 51. 2
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MISC (97)：
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中村 正帆, 長沼 史登, 田中 聖人, 井上 まり絵, 直野 留美, 吉川 雄朗, 岡村 信行. 扁桃体中心核ニューロテンシン神経細胞の睡眠覚醒サイクルにおける役割の検討. 応用薬理. 2022. 102. 5-6. 128-128
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吉川 雄朗, 松澤 拓郎, 谷内 一彦, 山口 祐. ブドウ糖代謝におけるヘパラン硫酸の役割について. 糖尿病. 2022. 65. Suppl.1. S-282
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谷内 一彦, 吉川 雄朗. 【皮膚科医が学ぶ睡眠医学-皮膚科診療に活かそう!】(Part1.)皮膚科医が知っておくべき睡眠の科学(総説7) ヒスタミンH1受容体拮抗薬による眠気と鎮静作用発生メカニズム. Visual Dermatology. 2022. 21. 3. 262-265
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吉川雄朗, 長沼史登, 長沼史登, 山田瑶, 吉川貴子, 大隅典子, 谷内一彦. Chronic histamine deletion in adult mouse brain induced depression-like behaviors, impairment of memory function and decrease of locomotor activity. 日本神経精神薬理学会プログラム・抄録集. 2020. 50th. 179-179
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横山 敦, 野呂 英理香, 松澤 拓郎, 吉川 雄朗, 島 弘季, 五十嵐 和彦, 菅原 明. 膵β細胞におけるグルコース応答性転写因子ChREBPの機能制御因子の探索. 日本生化学会大会プログラム・講演要旨集. 2019. 92回. [3T15m-04]
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Books (1)：
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創薬技術の革新 マイクロドーズからPET分子イメージングへの新展開
メディカルドゥ 2010
Lectures and oral presentations (295)：
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Evaluation of histamine N-methyltransferase inhibition on sleep- wake behavior in wild-type and narcolepsy model mice
(第37回北海道薬物作用談話会 2024)
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Evaluation of Therapeutic Potential for Histamine N-methyltransferase Inhibitior in Narcolepsy
(Neuro2024 2024)
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Inhibition of histamine metabolizing enzyme in the brain reduces cataplexy in narcolepsy model mice
(2024)
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ヒスタミン代謝酵素阻害薬の薬理作用について
(第24回日本ヒスタミン学会 2024)
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ナルコレプシーに対する創薬を目指して
(蔵王カンファレンス 2024)
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Education (2)：
- 2004 - 2008 Tohoku University Graduate School, Division of Medical Sciences
- 1996 - 2002 Tohoku University School of Medicine
Professional career (1)：
Work history (5)：
- 2023/10 - 現在 北海道大学脳科学研究教育センター 教員
- 2023/05 - 現在 Hokkaido University Graduate School of Medicine, Department of Neuropharmacology Professor
- 2016/04 - 2023/04 Tohoku University Graduate School of Medicine
- 2009/04 - 2016/03 Tohoku University Graduate School of Medicine
- 2002/04 - 2004/03 福島県太田総合病院附属太田西ノ内病院 研修医
Awards (7)：
Association Membership(s) (7)：
日本糖尿病学会
, 日本生化学会
, 日本神経科学学会
, 日本薬理学会
, Society for Neuroscience
, 日本臨床薬理学会
, 日本糖質学会
