Tani-ichi Shizue

Affiliation and department：

Research field (1)： Immunology

Research theme for competitive and other funds (11)：

2023 - 2026 Investigation of the function of IL-7 in skeletal muscle-residing Tregs and its therapeutic application to sarcopenia
2023 - 2026 Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes
2020 - 2023 IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases
2019 - 2022 Cytokine IL-7-mediated amelioration of insulin resistance
2016 - 2019 Control of innate immune cells, chronic inflammation and infection by cytokine-producing immune microenvironment

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Papers (42)：

Shinya Abe, Moe Kagao, Takuma Asahi, Ryoma Kato, Shizue Tani-ichi, Akihiro Shimba, Riki Ishibashi, Hitoshi Miyachi, Satsuki Kitano, Masaki Miyazaki, et al. The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow. The Journal of Immunology. 2025
Akihiro Shimba, Shizue Tani-Ichi, Kyoko Masuda, Guangwei Cui, Satoru Munakata, Shinya Abe, Satsuki Kitano, Hitoshi Miyachi, Hiroshi Kawamoto, Koichi Ikuta. A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells. Journal of immunology (Baltimore, Md. : 1950). 2024
Shizue Tani-ichi, David Obwegs, Alice Yoshikawa, Hitomi Watanabe, Satsuki Kitano, Aki Ejima, Shinya Hatano, Hitoshi Miyachi, Guangwei Cui, Akihiro Shimba, et al. A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells. The Journal of Immunology. 2024. 213. 3. 283-295
Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, et al. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell reports. 2023. 42. 9. 113127-113127
Guangwei Cui, Akihiro Shimba, Jianshi Jin, Nozomi Hojo, Takuma Asahi, Shinya Abe, Aki Ejima, Shinri Okada, Keizo Ohira, Ryoma Kato, et al. CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 36. e2215941120

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MISC (24)：

谷一靖江, 生田宏一. 【γδT細胞による生体制御】γδT細胞の恒常性維持機構. 炎症と免疫. 2022. 30. 3. 212-214
CUI Guangwei, 谷一靖江, 谷一靖江, 生田宏一. Roles of IL-7R signaling in differentiation and function of T lymphocytes. 生化学. 2021. 93. 6. 815-818
Shizue Tani-ichi. Function of IL-7 receptor signaling in the thymocyte development and peripheral T cells. 2017. 261. 11. 1065-1071
生田宏一, 阿部昌史, 谷一靖江. エンハンサーによるIL-7レセプターの発現の制御. 医学のあゆみ. 2016. 257. 11. 1170-1172
生田宏一, 原崇裕, 谷一靖江. 肝臓IL-7の新たな機能. 感染・炎症・免疫. 2014. 43. 4

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Lectures and oral presentations (22)：

Function of IL-7Rα in regulatory T cells / Shizue Tani-ichi*, Takahiro Hara, Koichi Ikuta
(2019)
Function of IL-7R in regulatory T cells
(29th Kyoto T Cell Conference 2019)
Exploring the signals upregulating IL-7Rα expression via NFκB activation in T cells / *Shizue Tani-ichi, Koichi Ikuta
(The 46th Annual Meeting of the Japanese Society for Immunology, Sendai, Japan 2017)
IL-7Rα signaling upregulates growth hormone signaling-related gene in naive T cells / *Shizue Tani-ichi, Koichi Ikuta
(Integrating Metabolism and Immunity, Dublin, Ireland 2017)
Role of TCRγ enhancer ‘Eγ4’ for the development and function of γδ T cells / *Shizue Tani-ichi, Koichi Ikuta
(International Congress of Immunology, Melbourne, Australia 2016)

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Professional career (1)：

Doctor of Health Science (Osaka University)

Work history (3)：

2021/04 - 2024/03 Kyoto University Graduate School of Medicine and Faculty of Medicine
2016/04 - 2021/03 Kyoto University Graduate School of Medicine
2007/04 - 2016/03 京都大学ウイルス研究所助教

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