Koshiba Seizo

コシバセイゾウ | Koshiba Seizo

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://www.ingem.oas.tohoku.ac.jp , https://www.ingem.oas.tohoku.ac.jp/english/

Research field (3)： Structural biochemistry , Medical biochemistry , Functional biochemistry

Research keywords (6)： omics , structural biology , biochemistry , metabolome , NMR , Cryo Electron Microscopy

Research theme for competitive and other funds (9)：

2024 - 2026 Identifying Novel Sepsis Endotypes
2023 - 2026 Identifying Novel Pathophysiology-related Sepsis Endotypes: Exploratory Research
2020 - 2024 Interdisciplinary fusion research for precision medicine in heart failure patients with preserved ejection fraction
2020 - 2023 乳癌罹患リスク低減に向けた遺伝子多型、生活習慣、血漿メタボロームの統合解析
2017 - 2023 19F-NMR法と常磁性効果を用いた細胞内環境下のタンパク質の基質認識機構の解明

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Papers (129)：

Akiko Hanyuda, Yoshihiko Raita, Takahiro Ninomiya, Kazuki Hashimoto, Naoko Takada, Kota Sato, Jin Inoue, Seizo Koshiba, Gen Tamiya, Akira Narita, et al. Metabolomic Profiling of Open-Angle Glaucoma Etiologic Endotypes: Tohoku Multi-Omics Glaucoma Study. Investigative ophthalmology & visual science. 2024. 65. 13. 44-44
Shuichi Sato, Takao Imaeda, Shunji Mugikura, Naoko Mori, Masaki Takanashi, Kazumi Hayakawa, Tomo Saito, Makiko Taira, Akira Narita, Mana Kogure, et al. Association of olfactory and cognitive function test scores with hippocampal and amygdalar grey matter volume: a cross-sectional study. Scientific reports. 2024. 14. 1. 19138-19138
Nobuo Fuse, Masae Kimura, Ai Shimizu, Seizo Koshiba, Teruhiko Hamanaka, Makoto Nakamura, Nobuo Ishida, Hiroshi Sakai, Yoko Ikeda, Kazuhiko Mori, et al. Mutations of CYP1B1 and FOXC1 genes for childhood glaucoma in Japanese individuals. Japanese journal of ophthalmology. 2024
Miyuki Sakurai, Ikuko N Motoike, Eiji Hishinuma, Yuichi Aoki, Shu Tadaka, Mana Kogure, Masatsugu Orui, Mami Ishikuro, Taku Obara, Naoki Nakaya, et al. Identifying critical age and gender-based metabolomic shifts in a Japanese population of the Tohoku Medical Megabank cohort. Scientific reports. 2024. 14. 1. 15681-15681
Sakura Kiuchi, Kumi Nakaya, Upul Cooray, Kenji Takeuchi, Ikuko N Motoike, Naoki Nakaya, Yasuyuki Taki, Seizo Koshiba, Shunji Mugikura, Ken Osaka, et al. A principal component analysis of metabolome and cognitive decline among Japanese older adults: cross-sectional analysis using Tohoku Medical Megabank Cohort Study. Journal of epidemiology. 2024

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MISC (42)：

内田新菜, 中井琢, 福内友子, 山岡法子, 小柴生造, 山本雅之, 鈴木教郎, 三枝大輔, 三枝大輔. Metabolic profiling of plasma and urine for the daprodustat treatment mice by GC-MS/MS. 日本薬学会年会要旨集(Web). 2024. 144th
三好慶太郎, 前川正充, 前川正充, 前川正充, 菱沼英史, 菱沼英史, 松川直美, 小柴生造, 小柴生造, 深澤征義, et al. Proteome analysis using model cells to reveal the molecular mechanism of Niemann-Pick disease type C pathogenesis. 日本薬学会年会要旨集(Web). 2024. 144th
松川直美, 菱沼英史, 菱沼英史, 嶋喜子, 重田昌吾, 工藤敬, 島田宗昭, 島田宗昭, 島田宗昭, 小柴生造, et al. Construction of plasma proteomics platform for large-scale analysis and its application to ovarian cancer biomarker discovery. 日本プロテオーム学会大会プログラム・抄録集. 2024. 2024 (Web)
菱沼英史, 菱沼英史, 島田宗昭, 島田宗昭, 島田宗昭, 松川直美, 萩原達也, 工藤敬, 渋谷祐介, 重田昌吾, et al. 血漿メタボローム解析を用いた婦人科癌におけるバイオマーカーの探索. 日本婦人科腫瘍学会学術講演会プログラム・抄録集(Web). 2024. 66th
三好慶太郎, 前川正充, 前川正充, 前川正充, 菱沼英史, 菱沼英史, 松川直美, 小柴生造, 小柴生造, 深澤征義, et al. 液体クロマトグラフィー/タンデム質量分析法を用いたニーマンピック病C型モデル細胞内プロテオーム変動解析. 次世代を担う若手のためのフィジカル・ファーマフォーラム講演要旨集. 2022. 19th

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Professional career (1)：

博士(理学) (東京大学)

Work history (2)：

2020/03 - 現在 Tohoku University Advanced Research Center for Innovations in Next-Generation Medicine Professor
2017/05 - 現在 Tohoku University Tohoku Medical Megabank Organization

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