Takubo Keiyo

タクボケイヨ | Takubo Keiyo

Affiliation and department：
Job title： Professor
Other affiliations (1)：

National Center for Global Health and Medicine

Homepage URL (1)： https://takubolab.com

Research field (2)： Medical biochemistry , Hematology and oncology

Research keywords (32)： stem cell metabolism , quiescence , hematopoietic stem cell , ニッチ , 低酸素 , 白血病幹細胞 , stem cell niche , HIF-1 , 酸素代謝 , 幹細胞純化 , メタボローム , 老化 , 未分化型精原細胞 , 精子幹細胞 , 血小板 , 低酸素応答 , G0期 , VHL , 静止期 , 巨核球 , 微小環境 , 活性酸素 , 自己複製能 , Angiopoietin-1 , 癌幹細胞 , 骨芽細胞 , Tie2 , Angiopoiedn-1 , 血液腫瘍疾患 , Fbw , 細胞周期 , Thrombopoietin

Research theme for competitive and other funds (23)：

2021 - 2024 Establishment of imaging technique for spatiotemporal dynamics of hematopoietic stem cells in bone marrow
2020 - 2023 Starvation response of the immune system along the gut-bone marrow axis
2020 - 2022 Spatio-temporal analysis of hematopoietic stem cell dynamics through visualization and manipulation of bone marrow oxygen environment
2018 - 2021 造血幹細胞ニッチ因子としての代謝物の時空間構成と機能解明
2018 - 2020 「かたち」と「うごき」に注目した造血幹細胞の分類・機能評価

2016 - 2019 Research on spleen microenvironment supporting extramedullary hematopoiesis and its application to the expansion of hematopoietic stem cells

2015 - 2019 Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

2014 - 2019 Molecular physiological studies of in vivo hypoxia niche: formation, sensing and adaptation

2014 - 2019 Establishing a new paradigm of pathogenesis of the diseases through the understanding of stem cell aging

2014 - 2019 Aging and anti-aging mechanisms in niche-hematopoietic stem cell interaction

2014 - 2019 Homeostasis of hematopoietic stem cells and its breakdown

2016 - 2018 Identification and characterization of biological targets of chemical expander for hematopoietic stem cells

2015 - 2018 Impact of hydroxylation signals on homeostatic regulation of hematopoiesis

2013 - 2015 造血幹細胞ニッチとしての巨核球の機能の解明

2011 - 2015 Elucidation of metabolic phenotypes of LICs and development of targeting therapy against LICs through Phd/VHL/HIF-1 regulatory system

2010 - 2015 Analysis of Niche Regulation for Cancer Stem Cells

2011 - 2014 Nicher Regulation for Normal Hemopoietic Stem Cells and Leukemic Stem Cells

2011 - 2013 低酸素適応システムによる巨核球への分化・成熟過程の解析

2010 - 2010 ニッチによる幹細胞の運命制御

2009 - 2010 未分化型精原細胞特異的遺伝子ネットワークによる幹細胞維持機構の解明

2009 - 2010 Molecular mechanisms for hematopoietic stem cells by HIF-1/VHL regulatory system

2004 - 2008 Regulation of Hematopoietic Stem Cell Division in a Niche

2006 - 2007 組織内酸素濃度による造血幹細胞維持機構の解明

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Papers (114)：

Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano, Yuriko Sorimachi, Keiyo Takubo, Kohjiro Ueki. Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice. Metabolism: clinical and experimental. 2024. 155796-155796
Takahito Iga, Hiroshi Kobayashi, Dai Kusumoto, Tsukasa Sanosaka, Nobuyuki Fujita, Ikue Tai-Nagara, Tomofumi Ando, Tomoko Takahashi, Koichi Matsuo, Katsuto Hozumi, et al. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nature Cell Biology. 2023
Keiyo Takubo, Phyo Wai Htun, Takeshi Ueda, Yasuyuki Sera, Masayuki Iwasaki, Miho Koizumi, Kohei Shiroshita, Hiroshi Kobayashi, Miho Haraguchi, Shintaro Watanuki, et al. MBTD1 preserves adult hematopoietic stem cell pool size and function. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2206860120
Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, et al. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells. Experimental hematology. 2023
Kohei Shiroshita, Hiroshi Kobayashi, Keiyo Takubo. Evaluating the function of murine quiescent hematopoietic stem cells following non-homologous end joining-based genome editing. STAR protocols. 2023. 4. 2. 102347-102347

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MISC (142)：

城下郊平, 城下郊平, 小林央, 片岡圭亮, 片岡圭亮, 田久保圭誉. Novel genome editing system optimized to preserve the hematopoietic stem cell function and phenotype. 日本血液学会学術集会抄録(Web). 2021. 83rd
城下郊平, 小林央, 田久保圭誉. 造血幹細胞とミトコンドリア代謝. 再生医療. 2020. 19. 3. 234-238
武田憲彦, 田久保圭誉. 【酸素環境と臓器機能感知・応答のメカニズムから最新の酸素イメージングまで】臓器機能を制御する酸素分圧「酸素パラドクス」の理解と技術基盤. 実験医学. 2020. 38. 9. 1424-1428
綿貫慎太郎, 小林央, 田久保圭誉. 【酸素環境と臓器機能感知・応答のメカニズムから最新の酸素イメージングまで】酸素環境と造血幹細胞システム. 実験医学. 2020. 38. 9. 1436-1440
藤田進也, 田久保圭誉. 【免疫と代謝】代謝による血液幹細胞の制御. 臨床免疫・アレルギー科. 2020. 73. 5. 467-471

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Books (1)：

「特集」酸素シグナルが細胞機能を揺り動かす! : NormoxiaからHypoxiaまで全身で行われるファインチューニング
羊土社 2015 ISBN:9784758101417

Lectures and oral presentations (19)：

造血幹細胞の運命制御
(日本比較免疫学会第30回学術集会 2018)
Functional alteration of hematopoietic stem cell niche during aging
(?IMSUT Mini-Symposium 2018)
Metabolic switch in hematopoietic stem cells during stress
(WCP2018 KYOTO Satellite Symposia 2018)
造血幹細胞ニッチのエイジング機構
(第18回日本抗加齢医学会総会 2018)
骨髄メタボローム解析に基づく造血幹細胞ニッチのエイジング機構の解析
(第6回がんと代謝研究会 2018)

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Professional career (1)：

博士(医学) (慶應義塾大学)

Work history (5)：

2023/12 - 現在 Tohoku University Graduate School of Medicine Professor
2014/04 - 現在 National Institute for Global Health and Medicine Research Institute Project director
2011/11 - 2015/03 Keio University School of Medicine Senior assistant professor
2008/04 - 2011/10 Keio University School of Medicine Assistant professor
2006/04 - 2008/03 The Japan Society for the Promotion of Science Research fellow

Awards (8)：

2017/11 - 長寿科学振興財団長寿科学賞
2017/03 - 国立国際医療研究センター箱根山賞
2016/04 - 日本リウマチ財団三浦記念リウマチ学術研究賞
2015/11 - 日本白血病基金日本白血病基金若手特別賞
2014/04 - 文部科学省文部科学大臣若手科学者賞

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