Rchr
J-GLOBAL ID：201401090171365535
Update date: May. 01, 2024
Yamazaki Tomohiro
ヤマザキ トモヒロ | Yamazaki Tomohiro
Affiliation and department：
Research field (1)：
Molecular biology
Research keywords (10)：
Paraspeckle
, NEAT1
, long noncoding RNA
, Phase separation
, Membraneless organelles
, Nuclear Body
, Block copolymer
, Micellization
, LLPS
, Amyotrophic Lateral Screlosis
Papers (44)：
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Ken-ichi Fujita, Tomohiro Yamazaki, Akila Mayeda, Seiji Masuda. Terminal regions of UAP56 and URH49 are required for their distinct complex formation functioning to an essential role in mRNA processing and export. Biochemical and Biophysical Research Communications. 2024. 149682-149682
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Ken-ichi Fujita, Misa Ito, Midori Irie, Kotaro Harada, Naoko Fujiwara, Yuya Ikeda, Hanae Yoshioka, Tomohiro Yamazaki, Masaki Kojima, Bunzo Mikami, et al. Structural differences between the closely related RNA helicases, UAP56 and URH49, fashion distinct functional apo-complexes. Nature Communications. 2024
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Rei Yoshimoto, Yuta Nakayama, Ikuko Nomura, Ikuko Yamamoto, Yumeka Nakagawa, Shigeyuki Tanaka, Misuzu Kurihara, Yu Suzuki, Takehiko Kobayashi, Hiroko Kozuka-Hata, et al. 4.5SH RNA counteracts deleterious exonization of SINE B1 in mice. Molecular cell. 2023
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Tetsuya Yamamoto, Tomohiro Yamazaki, Kensuke Ninomiya, Tetsuro Hirose. Nascent ribosomal RNA act as surfactant that suppresses growth of fibrillar centers in nucleolus. Communications biology. 2023. 6. 1. 1129-1129
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Hiro Takakuwa, Tomohiro Yamazaki, Sylvie Souquere, Shungo Adachi, Hyura Yoshino, Naoko Fujiwara, Tetsuya Yamamoto, Tohru Natsume, Shinichi Nakagawa, Gerard Pierron, et al. Shell protein composition specified by the lncRNA NEAT1 domains dictates the formation of paraspeckles as distinct membraneless organelles. Nature cell biology. 2023
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MISC (17)：
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高桑央, 高桑央, 山崎智弘, SOUQUERE Sylvie, 足達俊吾, 藤原奈央子, 吉野彪羅, 山本哲也, 中川真一, 村上正晃, et al. Shell protein composition specified by NEAT1 domains dictates the paraspeckle segregation from nuclear speckles. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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Tomohiro Yamazaki, Tetsuro Hirose. Roles of RNA in intracellular phase separation. 2022. 32-37
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廣瀬哲郎, 廣瀬哲郎, 山崎智弘, 山本哲也. RNAs acting as scaffolds of intracellular structures. 実験医学. 2022. 40. 12
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高桑央, 高桑央, 山崎智弘, SOUQUERE Sylvie, PIERRON Gerard, 村上正晃, 廣瀬哲郎, 廣瀬哲郎. Molecular grammar of the SFPQ prion-like domain for the paraspeckle segregation from nuclear speckles. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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山本哲也, 山崎智弘, 二宮賢介, 廣瀬哲郎. Nuclear body research by fusion of RNA molecular biology and soft matter physics. 月刊細胞. 2021. 53. 14
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Books (5)：
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Biology of phase separation
2020 ISBN:9784807913466
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細胞内の相分離(実験医学、6月号)
羊土社 2019
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医学のあゆみ
医歯薬出版株式会社 2019
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Applied RNA Science
Springer 2018
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ノンコーディング RNA テキストブック
羊土社 2015
Lectures and oral presentations (50)：
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RNAs as scaffolds of biomolecular condensates: Lessons from paraspeckles scaffolded by NEAT1_2 lncRNAs
(RNA Frontier Meeting 2021 2022)
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RNAs as scaffolds of biomolecular condensates: from LLPS to micellization
(MBSJ2021 2021)
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Paraspeckles are constructed as block copolymer micelles
(RNA Meeting 2021 2021)
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Paraspeckles: RNA-scaffolding Microphase separated Condensates
(MBSJ2020 2020)
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Design Principles of Architectural RNAs for Phase-separated Paraspeckle Nuclear Bodies
(Tokyo RNA club, the 26th meeting 2019)
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Professional career (1)：
Work history (4)：
- 2020/04 - 現在 Osaka University Graduate School of Frontier Biosciences Lecturer
- 2019/01 - 2020/03 Hokkaido University Institute for Genetic Medicine Lecturer
- 2014/02 - 2018/12 Hokkaido University Institute for Genetic Medicine Assistant Professor
- 2011/04 - 2014/01 Harvard Medical School Department of Cell Biology Research Fellow
Committee career (1)：
- 2022/04 - 現在 The RNA Society of Japan Finance Secretary
Awards (3)：
- 2017/12 - 北海道大学遺伝子病制御研究所 IGM研究者交流会、最優秀ポスター発表賞
- 2017/06 - 公益財団法人 内藤記念科学振興財団 第43回内藤カンファレンス、優秀発表賞
- 2011/01 - TOYOBO Biotechnology Foundation Award a research grant in-aid Establishment of the integrated model of human mRNA processing/export machinery
Association Membership(s) (4)：
The RNA Society
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE RNA SOCIETY OF JAPAN
, The Japanese Biochemical Society
