Research field (6)：
Pharmaceuticals - analytical and physicochemistry
, Molecular biochemistry
, Biochemistry
, Pharmaceuticals - chemistry and drug development
, Biophysics
, Digestive surgery
2017 - 2021 Development of new technologies for liver surgery by using fluorescent imaging
2017 - 2020 Development of indocyanine green-binding anti-cancer drug with specific accumulation in hepatocellular carcinoma
2017 - 2020 Development of a new pancreatic fistula prevention material via pancreatic fluid-responsive crosslinking
2016 - 2019 糖加水分解酵素蛍光プローブ群の開発による新規迅速がんイメージング手法の確立
2016 - 2019 Development of photodynamic therapy probes for cancer with single cell resolution and their evaluation with clinical samples
2015 - 2019 Promotion of oxygen biology on the basis of international networks
2014 - 2019 Oxygen biology: a new criterion for integrated understanding of life
2014 - 2019 Development of imaging probes and caged compounds for oxygen biology researches
2015 - 2017 Single molecule imaging of endogenous protein in living cells using spontaneously blinking fluorophore
2014 - 2017 Detection of head and neck cancer by spraying cancer-specific fluorescent probe
2014 - 2016 Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration
2013 - 2016 Mechanism of neuronal cell death in GM2 gangliosidosis
2011 - 2016 Establishment of new diagnostic imaging system for hepatocellular carcinoma and its application to cancer therapy
2011 - 2016 Development of molecular probes and photo manipulation tools - Technologies for visualization and control of small number of biomolecules
2012 - 2015 Regulation of neutrophil extracellular traps via fenton reaction and its application to the treatment of refractory autoimmune vasculitis
2011 - 2014 Development of novel luciferin analogues for utilizing luciferases as new functional tools in vivo
2011 - 2014 Development of fluorescence-guided HPB surgery and application of indocyanine green-fluorescence imaging to photodynamic therapy for liver cancer
2008 - 2014 Signaling Functions of Reactive Oxygen Species
2008 - 2012 Development of novel fluorescence probes and imaging technologies for elucidating the mechanism of cellular signaling and responses induced by ROS
2007 - 2010 Development of functional anti-cancer molecules based on precise control of excitation and relaxation pathways
2008 - 2008 in situがん細胞特性診断を可能とする蛍光プローブの開発とその応用
2007 - 2008 生体分子の高次デジタル計測を実現する光機能性プローブの開発とその応用
2004 - 2007 Development of Bioimaging Probes For In Vivo Application
2002 - 2006 Design and development of biological response modifiers
2003 - 2003 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2001 - 2003 Development of novel caged compounds that can report the yield of uncaged products
2002 - 2002 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2000 - 2002 STUDIES ON RATIONAL DESIGN PRINCIPLE FOR FLUORESCENCE ON/OFF SWITCHING
2000 - 2002 DEVELOPMENT OF FUNCTIONAL FLUORESCENT PROBES FOR BIOIMAGING
2001 - 2001 がん細胞中でのみ機能する、全く新しい原理に基づいた化学療法剤の開発
2000 - 2001 フルオレセイン類の蛍光On/Off原理の解明とその蛍光プローブ創製への応用
1999 - 2001 Investigation on the Chemical Property of Heme Thiolate Structure and Application to Medicinal Chemistry
1998 - 1999 酸化活性種の新規反応特性評価法に基づく、高選択的な不活性分子活性化系の構築
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Papers (307)：
Ziyi Wang, Ryosuke Kojima, Rikuki Kiji, Kyohhei Fujita, Ryo Tachibana, Taku Uchiyama, Yoshihiro Minagawa, Tadahaya Mizuno, Kiyohiko Igarashi, Hiroyuki Noji, et al. Low-Background Cancer Imaging With a Bioorthogonal Fluorescence Probe and Engineered Reporter Enzyme Bearing a Targeting Moiety. 2025
Mayano Minoda, Junpei Hatakeyama, Norimichi Nagano, Tadahaya Mizuno, Takumi Iwasaka, Sho Shiga, Kazuki Takahashi, Hideto Hiraide, Shingo Sakamoto, Yu Kagami, et al. Single-Molecule Oxidoreductase Activity Analysis for Activity-Based Diagnosis Based on Proteoform Alterations. Journal of the American Chemical Society. 2025
Kai Tahara, Akinobu Nakamura, Xiaotong Wang, Keishi Mitamura, Yuki Ichihashi, Keiko Kano, Emi Mishiro-Sato, Kazuhiro Aoki, Yasuteru Urano, Toru Komatsu, et al. γ-Secretase Cleaves Bifunctional Fatty Acid-Conjugated Small Molecules with Amide Bonds in Mammalian Cells. ACS chemical biology. 2024. 19. 12. 2438-2450
Mamiko Nakadate, Ryosuke Kojima, Naoki Seike, Ryo Tachibana, Kyohhei Fujita, Mako Kamiya, Andreas Plückthun, Yasuteru Urano. New class of fluorogenic probes for antigens based on DARPin-silicon pyronine conjugates. 2024
Yusuke Seki, Takeaki Ishizawa, Genki Watanabe, Toru Komatsu, Aika Nanjo, Tasuku Ueno, Yasuteru Urano, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Kiyoshi Hasegawa. Identification of a pancreatic juice-specific fluorescent probe through 411 probes activated by aminopeptidases/proteases or phosphatases/phosphodiesterases. HPB. 2024
