Amano Takanori

アマノタカノリ | Amano Takanori

Affiliation and department：
Job title： Team leader

Research field (2)： Genetics , Genomics

Research keywords (4)： complex diseases , disease model mouse , enhancer , gene regulation

Research theme for competitive and other funds (5)：

2019 - 2022 Modeling complex diseases using mouse subspecies strains
2015 - 2018 Cis-regulatory polymorphism responsible for allele-expression-bias that contributes to mouse phenotype
2016 - 2018 エンハンサーの共有と遮蔽を支える染色体ダイナミクス
2012 - 2015 Transcriptional regulation of Shh via chromosomal dynamics
2010 - 2012 Shh肢芽エンハンサー結合因子の網羅的探索

Papers (26)：

Reimi Tada, Takuya Higashidate, Takanori Amano, Shoma Ishikawa, Chifuyu Yokoyama, Suzu Kobari, Saki Nara, Koshiro Ishida, Akane Kawaguchi, Haruki Ochi, et al. The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis. Developmental Biology. 2023
Shigekazu Tanaka, Hajime Orita, Taro Kataoka, Masahiro Miyazaki, Harumi Saeki, Ryo Wada, Malcolm V Brock, Tetsu Fukunaga, Takanori Amano, Toshihiko Shiroishi. Gasdermin D Represses Inflammation-Induced Colon Cancer Development by Regulating Apoptosis. Carcinogenesis. 2023
Takanori Amano. Gene regulatory landscape of the sonic hedgehog locus in embryonic development. Development, growth & differentiation. 2020. 62. 5. 334-342
Sagai T, Amano T, Maeno A, Ajima R, Shiroishi T. SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization. Proceedings of the National Academy of Sciences of the United States of America. 2019. 116. 47. 23636-23642
Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT, Iseki S. Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development (Cambridge, England). 2019. 146. 21

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MISC (13)：

Kousuke Mouri, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi. Orientation-dependent enhancer evoked by chromosomal translocation in mouse Hm mutation. MECHANISMS OF DEVELOPMENT. 2017. 145. S139-S139
Takanori Amano, Toshihiko Shiroishi. Cis-regulatory polymorphism of Shh is involved in variation of shape and size of the mouse stomach. GENES & GENETIC SYSTEMS. 2016. 91. 6. 351-351
Tomoko Sagai, Takanori Amano, Akiteru Maeno, Youichi Mizushina, Hiromi Nakazawa, Toshihiko Shiroishi. Dosage effect of two Shh enhancers for control of tooth number in mouse. GENES & GENETIC SYSTEMS. 2016. 91. 6. 353-353
Kousuke Mouri, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi. Enhancer rearrangement causes regulatory change of gene expression. GENES & GENETIC SYSTEMS. 2016. 91. 6. 373-373
嵯峨井知子, 天野孝紀, 前野哲輝, 水品洋一, 中澤博美, 城石俊彦. マウスの歯数を制御する二つのShhエンハンサーの量的効果. 日本遺伝学会大会プログラム・予稿集. 2016. 88th

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Patents (1)：

Books (4)：

Lectures and oral presentations (18)：

Shh遺伝子の発現を制御する染色体高次構造の動態
(東北大学加齢医学研究所研究員会セミナー 2011)
Long-rangeエンハンサーによるShh遺伝子の発現制御
(みんなで建設的に考える会 2011)
A BAC-transgenic mouse model for the long-range enhancer-promoter interaction at the Shh locus
(2011)
A mouse mutation Rim4 with duplication of a 7Mb segment of chromosome 8 is model of Partial trisomy 4q-ter syndrome that exhibits congenital malformation
(23th INTERNATIONAL MOUSE GENOME CONFERENCE 2009 2009)
Long-range enhancer-promoter interaction via chromosomal dynamics at the Shh locus
(23th INTERNATIONAL MOUSE GENOME CONFERENCE 2009 2009)

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Education (3)：

2002 - 2005 Tohoku University Graduate School of Life Sciences Department of Developmental Biology and Neurosciences
2000 - 2002 Tohoku University Graduate School of Science Department of Biology
1996 - 2000 Tohoku University Faculty of Science Department of Biology

Professional career (1)：

Work history (3)：

2018/07 - 現在 RIKEN BioResource Research Center Next Generation Human Disease Model Team Team Leader
2013/11 - 2018/03 National Institute of Genetics Mammalian Genetics Laboratory Assistant professor
2005/04 - 2013/10 National Institute of Genetics Mammalian Genetics Laboratory Research postdoc

Association Membership(s) (2)：

THE GENETICS SOCIETY OF JAPAN , JAPANESE SOCIETY OF DEVELOPMENTAL BIOLOGISTS

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