Art

J-GLOBAL ID：201402201549967423   Reference number：14A0467195

A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

単一の腫瘍形成エンハンサー再編成は白血病においてEVI1とGATA2の同時制御解除を引き起こす

Author (24)： GROESCHEL Stefan (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  GROESCHEL Stefan (Dep. of Internal Medicine III, Ulm Univ. Hospital, 89081 Ulm, DEU) ,  SANDERS Mathijs A. (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  HOOGENBOEZEM Remco (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  DE WIT Elzo (Hubrecht Institute-KNAW and Univ. Medical Center Utrecht, Utrecht, 3584 CT, NLD) ,  BOUWMAN Britta A.M. (Hubrecht Institute-KNAW and Univ. Medical Center Utrecht, Utrecht, 3584 CT, NLD) ,  ERPELINCK Claudia (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  VAN DER VELDEN Vincent H.J. (Dep. of Immunology, Erasmus Univ. Medical Center, Rotterdam, 3015 CN, NLD) ,  HAVERMANS Marije (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  AVELLINO Roberto (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  VAN LOM Kirsten (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  ROMBOUTS Elwin J. (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  VAN DUIN Mark (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  DOEHNER Konstanze (Dep. of Internal Medicine III, Ulm Univ. Hospital, 89081 Ulm, DEU) ,  BEVERLOO H. Berna (Dep. of Clinical Genetics, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  BEVERLOO H. Berna (Dutch Working Group on Hemato-Oncologic Genome Diagnostics, Rotterdam, 3015 GE, NLD) ,  BRADNER James E. (Dep. of Medical Oncology, Dana-Farber Cancer Inst., Boston, MA 02115, USA) ,  BRADNER James E. (Dep. of Medicine, Harvard Medical School, Boston, MA 02115, USA) ,  DOEHNER Hartmut (Dep. of Internal Medicine III, Ulm Univ. Hospital, 89081 Ulm, DEU) ,  LOEWENBERG Bob (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  VALK Peter J.M. (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  BINDELS Eric M.J. (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD) ,  DE LAAT Wouter (Hubrecht Institute-KNAW and Univ. Medical Center Utrecht, Utrecht, 3584 CT, NLD) ,  DELWEL Ruud (Dep. of Hematology, Erasmus Univ. Medical Center, Rotterdam, 3015 GE, NLD)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 157  Issue： 2  Page： 369-381  Publication year： Apr. 10, 2014 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *DNA binding protein ,  *transcription factor ,  *repressor ,  *acute myeloid leukemia ,  human ,  enhancer ,  Chromosome Aberrations ,  gene dosage effect ,  Proteins ,  post-translational modification ,  single nucleotide polymorphism ,  *EVI1 ,  P300 ,  Haploinsufficiency ,  *GATA2 Transcription Factor ,  Chromosomal rearrangements ,  cellular genetic phenomenon ,  molecular genetic phenomenon
Semi thesaurus term： *GATA-2 ,  chromosome rearrangement

JST classification (4)： Blood cell tumors(=neoplasms)  (GK04000M) ,  Carcinogenic mechanisms and factors  (GE02020C) ,  Biological function  (EB03040U) ,  Molecular genetics in general  (EC02010J)

Terms in the title (5)： 腫瘍形成 ,  再編成 ,  白血病 ,  EVI1 ,  GATA2