Art

J-GLOBAL ID：201402201573147763   Reference number：14A0282297

Biology- and Diversity-Oriented Domino Reactions for Synthesis of AMPA Receptor Antagonist IKM-159 and Analogues

AMPA受容体拮抗薬IKM-159および類似体の合成のための生物学および多様性指向ドミノ反応

Author (6)： OIKAWA Masato (Yokohama City Univ., Yokohama, JPN) ,  KASORI Yuuki (Yokohama City Univ., Yokohama, JPN) ,  KATAYAMA Lisa (Yokohama City Univ., Yokohama, JPN) ,  MURAKAMI Etsuko (Yokohama City Univ., Yokohama, JPN) ,  OIKAWA Yuya (Yokohama City Univ., Yokohama, JPN) ,  ISHIKAWA Yuichi (Yokohama City Univ., Yokohama, JPN)
Material： Synthesis  (Journal of Synthetic Organic Chemistry)
Volume： 45  Issue： 22  Page： 3106-3117  Publication year： Nov. 18, 2013 
JST Material Number： D0738A  ISSN： 0039-7881  CODEN： SYNTBF  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： *AMPA receptor ,  *amino acid ,  consecutive reaction ,  condensation reaction ,  Diels-Alder reaction ,  metathesis ,  structure-activity relationship
Semi thesaurus term： Ugi reaction ,  *amino acid derivatives ,  domino reaction ,  Receptor antagonist

JST classification (1)： Amino acids  (CF10070V)

Substance index (15)： IKM-159 ,  rac-(4aα^*,8aβ^*,8bα^*)-3α^*,4α^*-Dihydroxy-6β^*-carboxy-8-oxodecahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-5aβ^*-acetic acid ,  rac-3-Oxo-9aα^*-(2-oxo-2-hydroxyethyl)-2,3,3aα^*,3bβ^*,5,6,8aβ^*,9a-octahydro-2-aza-4,9-dioxa-1H-cyclopenta[a]azulene-1α^*-carboxylic acid ,  rac-2-Oxo-3α^*-butyl-4-hydroxy-5β^*-carboxypyrrolidine-4β^*-acetic acid ,  rac-(3aβ^*)-Hexahydro-2β^*-vinyl-4-oxo-6aβ^*-(carboxymethyl)-2H-furo[2,3-c]pyrrole-6β^*-carboxylic acid ,  rac-(3aβ^*)-Hexahydro-2β^*-vinyl-4-oxo-5-(2-hydroxyethyl)-6aβ^*-(carboxymethyl)-2H-furo[2,3-c]pyrrole-6β^*-carboxylic acid ,  1-(4-Nitrophenylsulfonyl)-5aα-(2-oxo-2-methoxyethyl)-7-(4-methoxybenzyl)-8-oxo-2,4aβ,5a,6,7,8,8aα,8bβ-octahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6α-carboxylic acid methyl ester ,  1-(4-Nitrophenylsulfonyl)-5aα-(2-oxo-2-methoxyethyl)-8-oxo-2,4aβ,5a,6,7,8,8aα,8bβ-octahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6α-carboxylic acid methyl ester ,  5aα-(2-Oxo-2-methoxyethyl)-8-oxo-2,4aβ,5a,6,7,8,8aα,8bβ-octahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6α-carboxylic acid methyl ester ,  5aα-(2-Oxo-2-methoxyethyl)-8-oxo-2,4aβ,5a,6,7,8,8aα,8bβ-octahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-1,6α-dicarboxylic acid 1-tert-butyl 6-methyl ester ,  3β,4β-Dihydroxy-5aα-(2-oxo-2-methoxyethyl)-8-oxo-2,3,4,4aβ,5a,6,7,8,8aα,8bβ-decahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-1,6α-dicarboxylic acid 1-tert-butyl 6-methyl ester ,  3β,4β-(Isopropylidenebisoxy)-5aα-(2-oxo-2-methoxyethyl)-8-oxo-2,3,4,4aβ,5a,6,7,8,8aα,8bβ-decahydro-1H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-1,6α-dicarboxylic acid 1-tert-butyl 6-methyl ester ,  2-(4-Methoxybenzyl)-3-oxo-9aα-(2-oxo-2-methoxyethyl)-2,3,3aα,3bβ,5,6,8aβ,9a-octahydro-2-aza-4,9-dioxa-1H-cyclopenta[a]azulene-1α-carboxylic acid methyl ester ,  3-Oxo-9aα-(2-oxo-2-methoxyethyl)-2,3,3aα,3bβ,5,6,8aβ,9a-octahydro-2-aza-4,9-dioxa-1H-cyclopenta[a]azulene-1α-carboxylic acid methyl ester ,  (Z)-3-Iodoacrylic acid

Terms in the title (6)： AMPA受容体 ,  拮抗薬 ,  類似体 ,  生物学 ,  多様性 ,  ドミノ反応