Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: Results of a randomized, vehicle-controlled, multicenter clinical trial

FURUE Masutaka; KITAHARA Yasumi; AKAMA Hideto; HOJO Seiichiro; HAYASHI Nobukazu; NAKAGAWA Hidemi

Art

J-GLOBAL ID：201402202528470754 Reference number：14A0977276

Safety and efficacy of topical E6005, a phosphodiesterase 4 inhibitor, in Japanese adult patients with atopic dermatitis: Results of a randomized, vehicle-controlled, multicenter clinical trial

アトピー性皮膚炎の日本人成人患者におけるホスホジエステラーゼ4阻害剤,局所E6005の安全性および効果:無作為,ビークル対照,多施設臨床試験結果

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Material：
Volume： 41 Issue： 7 Page： 577-585 Publication year： Jul. 2014
JST Material Number： W1578A ISSN： 0385-2407 Document type： Article
Article type：原著論文 Country of issue： Australia (AUS) Language： ENGLISH (EN)

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Drug therapy(=pharmacotherapy)for skin diseases , Clinical application of enzyme preparations and inhibitor preparations , Treatment for immunologic diseases,allergic diseases. , Epidemiology

Reference (30)：

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Saeki H, Furue M, Furukawa F et al. Guidelines for management of atopic dermatitis. J Dermatol 2009; 36: 563-577.
Grewe SR, Chan SC, Hanifin JM. Elevated leukocyte cyclic AMP-phosphodiesterase in atopic disease: a possible mechanism for cyclic AMP-agonist hyporesponsiveness. J Allergy Clin Immunol 1982; 70: 452-457.
Chan SC, Reifsnyder D, Beavo JA, Hanifin JM. Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol 1993; 91: 1179-1188.
Hanifin JM, Chan SC, Cheng JB et al. Type 4 phosphodiesterase inhibitors have clinical and in vitro anti-inflammatory effects in atopic dermatitis. J Invest Dermatol 1996; 107: 51-56.

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