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J-GLOBAL ID：201402203450666181   Reference number：14A1146622

Structure and function of thrombin activatable fibrinolysis inhibitor

TAFIの構造と機能
Author (3)：
MIURA ATSUSHI

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, 
HOSONO TAKASHI

About HOSONO TAKASHI

, 
SEKI TAIICHIRO

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Material：
日本血栓止血学会誌  (Japanese Journal of Thrombosis and Hemostasis)

About 日本血栓止血学会誌


Volume： 25  Issue： 4  Page： 512-515 (J-STAGE)  Publication year： 2014 
JST Material Number： L2757A  ISSN： 0915-7441  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)
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human

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,...
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*thrombin-activatable fibrolysis inhibitor

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,...
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JST classification (3)：
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Category name(code) classified by JST.
Clinical hematology in general 
(GK01030Y)

About Clinical hematology in general

,  Fibrinolysis and blood coagulation 
(EJ03040S)

About Fibrinolysis and blood coagulation

,  Enzyme physiology 
(EJ02020P)

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Reference (10)：
  • 1) Declerck PJ: Thrombin activatable fibrinolysis inhibitor. Hamostaseologie 31:165-166, 168-173, 2011.
  • 2) Rijken DC, Lijnen HR: New insights into the molecular mechanisms of the fibrinolytic system. J Thromb Haemost 7: 4-13, 2009.
  • 3) Foley JH, Kim PY, Mutch NJ, Gils A: Insights into thrombin activatable fibrinolysis inhibitor function and regulation. J Thromb Haemost 11 Suppl 1:306-315, 2013.
  • 4) Marx PF, Brondijk TH, Plug T, Romijn RA, Hemrika W, Meijers JC, Huizinga EG: Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation. Blood 112: 2803-2809, 2008.
  • 5) Anand K, Pallares I, Valnickova Z, Christensen T, Vendrell J, Wendt KU, Schreuder HA, Enghild JJ, Avilés FX: The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa. J Biol Chem 283: 29416-29423, 2008.
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TAFI

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