Art

J-GLOBAL ID：201402214138451129   Reference number：14A0556701

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD⁺/SIRT1 Reduction

PARP-1過剰活性化とNAD⁺/SIRT1低下を介したXPAにおけるマイトファジー障害

Author (10)： FANG Evandro Fei (Lab. of Molecular Gerontology, National Inst. on Aging, National Institutes of Health, Baltimore, MD 21224, USA) ,  SCHEIBYE-KNUDSEN Morten (Lab. of Molecular Gerontology, National Inst. on Aging, National Institutes of Health, Baltimore, MD 21224, USA) ,  BRACE Lear E. (Dep. of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  KASSAHUN Henok (The Biotechnology Center, Univ. of Oslo, Oslo 0317, NOR) ,  SENGUPTA Tanima (The Biotechnology Center, Univ. of Oslo, Oslo 0317, NOR) ,  NILSEN Hilde (The Biotechnology Center, Univ. of Oslo, Oslo 0317, NOR) ,  MITCHELL James R. (Dep. of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA) ,  CROTEAU Deborah L. (Lab. of Molecular Gerontology, National Inst. on Aging, National Institutes of Health, Baltimore, MD 21224, USA) ,  BOHR Vilhelm A. (Lab. of Molecular Gerontology, National Inst. on Aging, National Institutes of Health, Baltimore, MD 21224, USA) ,  BOHR Vilhelm A. (Danish Center for Healthy Aging, Univ. of Copenhagen, Copenhagen, Blegdamsvej 3B 2200, DNK)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 157  Issue： 4  Page： 882-896  Publication year： May. 08, 2014 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： computer simulation ,  cultured cell ,  human(primates) ,  mouse(animal) ,  Caenorhabditis elegans ,  *phagocytosis ,  mitochondria ,  *DNA binding protein ,  cell physiology ,  DNA repair ,  ADP ribosyltransferase ,  coenzyme ,  histone deacetylase ,  protein ,  adenine nucleotide ,  nicotinamide mononucleotide ,  dinucleotide
Semi thesaurus term： PARP-1 ,  SIRT1 ,  *XPA protein ,  human cultured cell ,  *mitophagy ,  mitochondrial function ,  Xeroderma Pigmentosum Group A Protein

JST classification (2)： Cell physiology in general  (EF02010S) ,  Biological function  (EB03040U)

Substance index (1)： NAD

Terms in the title (7)： PARP-1 ,  活性化 ,  NAD+ ,  SIRT1 ,  XPA ,  マイトファジー ,  障害