Art

J-GLOBAL ID：201402214381650601   Reference number：14A0227123

Role of p38 Mapk in Development of Acute Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model of Human Wilson’s Disease

ロングエバンスシナモン(LEC)ラット(ヒトWilson病の動物モデル)における急性肝臓障害の発生におけるp38Mapkの役割 ヒトWilson病の動物モデル

Author (6)： KADOWAKI Shingo (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  MEGURO Saori (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  IMAIZUMI Yoshitaka (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  SAKAI Hiroshi (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  ENDOH Daiji (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  HAYASHI Masanobu (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 75  Issue： 12  Page： 1551-1556 (J-STAGE)  Publication year： 2013 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： rat ,...
Semi thesaurus term： LEC rat ,...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=14A0227123&from=J-GLOBAL&jstjournalNo=F0905A") }}

JST classification (2)： Medical care and clinical equipment of animals  (FE01020U) ,  Other animal diseases  (FE02060T)

Substance index (1)： SB-203580

Reference (34)：

• 1. Ashwell, J. D.2006. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat. Rev. Immunol. 6: 532-540.
• 2. Borsch-Haubold, A. G., Pasquet, S. and Watson, S. P.1998. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB203580 and PD 98059. J. Biol. Chem. 273: 28766-28772.
• 3. Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J. R. and Cox, D. W.1993. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5: 327-337.
• 4. Dent, P., Yacoub, A., Contessa, J., Caron, R., Amorino, G., Valerie, K., Hagan, M. P., Grant, S. and Schmidt-Ullrich, R.2003. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat. Res. 159: 283-300.
• 5. Fong, R. N., Gonzalez, B. P. E., Fuentealba, I. C. and Cherian, M. G.2004. Role of tumor necrosis factor-α in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats. Toxicol. Appl. Pharmacol. 200: 121-130.

Terms in the title (8)： ラット ,  ヒト ,  Wilson病 ,  動物 ,  モデル ,  肝臓障害 ,  p38MAPK ,  役割