Art

J-GLOBAL ID：201402214381650601   Reference number：14A0227123

Role of p38 Mapk in Development of Acute Hepatic Injury in Long-Evans Cinnamon (LEC) Rats, an Animal Model of Human Wilson’s Disease

ロングエバンスシナモン(LEC)ラット(ヒトWilson病の動物モデル)における急性肝臓障害の発生におけるp38Mapkの役割 ヒトWilson病の動物モデル

Author (6)： KADOWAKI Shingo (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  MEGURO Saori (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  IMAIZUMI Yoshitaka (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  SAKAI Hiroshi (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  ENDOH Daiji (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN) ,  HAYASHI Masanobu (Dep. of Basic Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen Univ., Ebetsu, Hokkaido 069-8501, JPN)
Material： Journal of Veterinary Medical Science  (日本獣医学会会誌)
Volume： 75  Issue： 12  Page： 1551-1556 (J-STAGE)  Publication year： 2013 
JST Material Number： F0905A  ISSN： 0916-7250  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： Rattus ,...
Semi thesaurus term： *急性肝臓障害

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JST classification (2)： Medical care and clinical equipment of animals  (FE01020U) ,  Other animal diseases  (FE02060T)

Substance index (1)： SB-203580

Reference (34)：

• 1. Ashwell, J. D.2006. The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat. Rev. Immunol. 6: 532-540.
• 2. Borsch-Haubold, A. G., Pasquet, S. and Watson, S. P.1998. Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB203580 and PD 98059. J. Biol. Chem. 273: 28766-28772.
• 3. Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J. R. and Cox, D. W.1993. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene. Nat. Genet. 5: 327-337.
• 4. Dent, P., Yacoub, A., Contessa, J., Caron, R., Amorino, G., Valerie, K., Hagan, M. P., Grant, S. and Schmidt-Ullrich, R.2003. Stress and radiation-induced activation of multiple intracellular signaling pathways. Radiat. Res. 159: 283-300.
• 5. Fong, R. N., Gonzalez, B. P. E., Fuentealba, I. C. and Cherian, M. G.2004. Role of tumor necrosis factor-α in the development of spontaneous hepatic toxicity in Long-Evans Cinnamon rats. Toxicol. Appl. Pharmacol. 200: 121-130.

Terms in the title (8)： ラット ,  ヒト ,  Wilson病 ,  動物 ,  モデル ,  肝臓障害 ,  p38MAPK ,  役割