Art

J-GLOBAL ID：201402221116571640   Reference number：14A1475259

Synthesis and Biological Evaluation of Kendomycin and Its Analogues

ケンドマイシンおよび類似体の合成と生物学的評価

Author (9)： TANAKA Kyosuke (Keio Univ., Yokohama, JPN) ,  MATSUYAMA Hiroshi (Keio Univ., Yokohama, JPN) ,  WATANABE Masahito (Keio Univ., Yokohama, JPN) ,  FUJIMORI Yukiko (Keio Univ., Yokohama, JPN) ,  ISHIBASHI Kodai (Keio Univ., Yokohama, JPN) ,  OZAWA Tomohiro (Keio Univ., Yokohama, JPN) ,  SATO Tomoharu (Keio Univ., Yokohama, JPN) ,  SAIKAWA Yoko (Keio Univ., Yokohama, JPN) ,  NAKATA Masaya (Keio Univ., Yokohama, JPN)
Material： Journal of Organic Chemistry  (J Org Chem)
Volume： 79  Issue： 21  Page： 9922-9947  Publication year： Nov. 07, 2014 
JST Material Number： C0328A  ISSN： 0022-3263  CODEN： JOCEAH  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： endothelin antagonist ,  Streptomyces ,  antibacterial action ,  MRSA ,  Enterococcus ,  analogical material ,  total synthesis ,  *antibiotics ,  cyclization reaction ,  annulation ,  structure-activity relationship ,  *oxygen heterocyclic compound ,  in vitro experiment
Semi thesaurus term： vancomycin-resistant enterococcus ,  endothelin receptor antagonist ,  analogue ,  benzannulation

JST classification (3)： Eight or more-membered heterocyclic compounds  (CF07120T) ,  Synthesis of antibiotics  (GX04000Z) ,  Structure-activity relationship of drugs  (GV01050B)

Substance index (12)： Kendomycin ,  Octadecane-17-ynal ,  2-Methyleneoctadecane-17-yne-1-ol ,  4-Methylene-20-(tert-butyldimethylsilyloxy)-22-methyl-2-oxabicyclo[17.3.1]tricosane-1(23),19,21-triene ,  4-Methylene-22-methyl-2-oxabicyclo[17.3.1]tricosane-1(23),19,21-triene-20-ol ,  3-Methylene-19-(tert-butyldimethylsilyloxy)-21-methylbicyclo[16.4.0]docosane-1(18),19,21-triene-22-ol ,  20-Hydroxy-21-methylbicyclo[16.4.0]docosane-1(18),20-diene-3,19,22-trione ,  2,4-(Tetradecane-1,14-diyl)-2,5-dihydroxy-7-methylbenzofuran-6(2H)-one ,  (2S)-2-((4R,5S,6R)-2,2,5-Trimethyl-6-(10-(tert-butylcarbonyloxy)decyl)-1,3-dioxane-4-yl)propane-1-ol ,  (2R)-1-Ethynyl-2-((4S,5S,6R)-2,2,5-trimethyl-6-(10-(tert-butylcarbonyloxy)decyl)-1,3-dioxane-4-yl)propane-1-ol ,  (13R,14R,15S,16R)-14,16,21-Trimethyl-13,17-epoxy-2-oxabicyclo[16.3.1]docosane-1(22),18,20-triene-15,19-diol ,  (2R,3S,4S)-2-(1,3-Dithiane-2-yl)-4-methyl-5-hexene-3-ol

Terms in the title (3)： ケンドマイシン ,  類似体 ,  生物学的評価