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J-GLOBAL ID：201402233790103153   Reference number：14A1499273

RNF43 is frequently mutated in colorectal and endometrial cancers

ユビキチンリガーゼ:RNF43は大腸がんおよび子宮内膜がんにおいて高頻度に変異している

Author (32)： GIANNAKIS Marios (Harvard Medical School, Massachusetts, USA) ,  HODIS Eran (Harvard Medical School, Massachusetts, USA) ,  MU Xinmeng Jasmine (Harvard Medical School, Massachusetts, USA) ,  YAMAUCHI Mai (Harvard Medical School, Massachusetts, USA) ,  ROSENBLUH Joseph (Harvard Medical School, Massachusetts, USA) ,  QIAN Zhi Rong (Harvard Medical School, Massachusetts, USA) ,  NISHIHARA Reiko (Harvard Medical School, Massachusetts, USA) ,  VAN ALLEN Eliezer M (Harvard Medical School, Massachusetts, USA) ,  HAHN William C (Harvard Medical School, Massachusetts, USA) ,  OGINO Shuji (Harvard Medical School, Massachusetts, USA) ,  FUCHS Charles S (Harvard Medical School, Massachusetts, USA) ,  GARRAWAY Levi A (Harvard Medical School, Massachusetts, USA) ,  GIANNAKIS Marios (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  HODIS Eran (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  MU Xinmeng Jasmine (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  ROSENBLUH Joseph (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  CIBULSKIS Kristian (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  SAKSENA Gordon (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  LAWRENCE Michael S (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  VAN ALLEN Eliezer M (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  HAHN William C (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  GABRIEL Stacey B (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  LANDER Eric S (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  GETZ Gad (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  GARRAWAY Levi A (Broad Inst. of MIT and Harvard, Massachusetts, USA) ,  HODIS Eran (Massachusetts Inst. of Technol., Massachusetts, USA) ,  HODIS Eran (Harvard Univ., Massachusetts, USA) ,  NISHIHARA Reiko (Harvard School of Public Health, Massachusetts, USA) ,  OGINO Shuji (Harvard School of Public Health, Massachusetts, USA) ,  LANDER Eric S (Massachusetts Inst. of Technol., Massachusetts, USA) ,  LANDER Eric S (Harvard Medical School, Massachusetts, USA) ,  GETZ Gad (Harvard Medical School, Massachusetts, USA)
Material： Nature Genetics  (Nat Genet)
Volume： 46  Issue： 12  Page： 1264-1266  Publication year： Dec. 2014 
JST Material Number： W0430A  ISSN： 1061-4036  Document type： Article
Article type： 短報  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *gene ,  peptide synthase ,  colorectal neoplasm ,  endometrial carcinoma ,  *mutation ,  oncogene ,  *carcinogenesis ,  human(primates) ,  APC gene
Semi thesaurus term： E3 ubiquitin ligase ,  *RNF43遺伝子 ,  *somatic mutation

JST classification (2)： Genetic variation  (EC01030Y) ,  Carcinogenic mechanisms and factors  (GE02020C)

Terms in the title (6)： ユビキチンリガーゼ ,  RNF43 ,  大腸がん ,  子宮内膜がん ,  頻度 ,  変異