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J-GLOBAL ID：201402235309531638   Reference number：14A0166201

Significance of Matrix Metalloproteinase-9 Inhibition by Imidapril for Prevention of Abdominal Aortic Aneurysms in Angiotensin II Type 1 Receptor-Knockout Mice

アンギオテンシンII 1型受容体-ノックアウトマウスにおける腹部大動脈瘤の予防のためのイミダプリルによるマトリックス・メタロプロテイナーゼ-9阻害の重要性

Author (6)： TAKAI Shinji (Dep. of Pharmacology, Osaka Medical Coll., JPN) ,  JIN Denan (Dep. of Pharmacology, Osaka Medical Coll., JPN) ,  YAMAMOTO Daisuke (Biomedical Computation Center, Osaka Medical Coll., JPN) ,  LI Zhong-lian (Dep. of Anatomy and Cell Biology, Osaka Medical Coll., JPN) ,  OTSUKI Yoshinori (Dep. of Anatomy and Cell Biology, Osaka Medical Coll., JPN) ,  MIYAZAKI Mizuo (Dep. of Pharmacology, Osaka Medical Coll., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 123  Issue： 2  Page： 185-194 (J-STAGE)  Publication year： 2013 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *aortic aneurysm ,...

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JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (1)： Imidapril

Reference (45)：

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• 2 Prisant LM, Mondy JS 3rd. Abdominal aortic aneurysm. J Clin Hypertens. 2004;6:85-89.
• 3 Daugherty A, Manning MW, Cassis LA. Ang II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest. 2000;105:1605-1612.
• 4 Ayabe N, Babaev VR, Tang Y, Tanizawa T, Fogo AB, Linton MF, et al. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice. Atherosclerosis. 2006;184:312-321.
• 5 Chen J, Kuhlencordt PJ, Astern J, Gyurko R, Huang PL. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein E/endothelial nitric oxide synthase double knockout mice. Circulation. 2001;104:2391-2394.

Terms in the title (10)： アンギオテンシンII ,  受容体 ,  ノックアウトマウス ,  腹部大動脈瘤 ,  予防 ,  イミダプリル ,  マトリックス ,  メタロプロテイナーゼ ,  阻害 ,  重要性