Art

J-GLOBAL ID：201402237779024050   Reference number：14A0466155

New insights into the mechanism of neurolathyrism: L-β-ODAP triggers [Ca²⁺]_i accumulation and cell death in primary motor neurons through transient receptor potential channels and metabotropic glutamate receptors

神経ラチリズムの機構に対する新しい洞察:L-β-ODAPは一過性受容体電位チャンネル及び代謝調節型グルタミン酸受容体によって一次運動ニューロンにおける[Ca²⁺]_i蓄積及び細胞死を誘発する

Author (13)： KUSAMA-EGUCHI Kuniko (Lab. of Biochemistry, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  KUSAMA-EGUCHI Kuniko (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  MIYANO Takaaki (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  YAMAMOTO Makoto (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  YAMAMOTO Makoto (Lab. of Pharmacology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  SUDA Atsuhiro (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  ITO Yoshihisa (Lab. of Pharmacology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  ISHIGE Kumiko (Lab. of Pharmacology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  ISHII Mayuko (Lab. of Biochemistry, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  OGAWA Yoshio (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  WATANABE Kazuko (Lab. of Molecular Cell Biology, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN) ,  IKEGAMI Fumio (Center for Environment, Health and Field Sciences, Chiba Univ., Kashiwanoha 6-2-1, Kashiwa 277-0822, JPN) ,  KUSAMA Tadashi (Lab. of Physiology and Anatomy, School of Pharmacy, Nihon Univ., Narashinodai 7-7-1, Funabashi 274-8555, JPN)
Material： Food and Chemical Toxicology  (Food Chem Toxicol)
Volume： 67  Page： 113-122  Publication year： May. 2014 
JST Material Number： B0937A  ISSN： 0278-6915  CODEN： FCTOD7  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： neuromuscular disease ,  *Calcium ,  AMPA receptor ,  Calcium Channels ,  Ion Channels ,  Membrane Proteins ,  *Cell Death ,  *glutamate receptor ,  time course ,  aromatic nitro compound ,  lactam ,  sulfonamide ,  polynuclear aromatic compound ,  amino acid ,  nitrogen heterocyclic compound ,  olefin compound ,  dicarboxylic acid ,  alicyclic compound ,  oxygen heterocyclic compound ,  onium compound ,  bridged compound ,  zwitterion ,  polyol ,  carboxylate (ester) ,  aromatic amine ,  aromatic carboxylic acid ,  organofluorine compound ,  aminocarboxylic acid ,  secondary amine ,  *intracellular calcium ,  Transient Receptor Potential Channels ,  *Receptors, Metabotropic Glutamate ,  Ion Transport ,  transportation ,  Biological Transport ,  transmembrane protein ,  ion transport(in vivo) ,  calcium antagonist
Semi thesaurus term： TRP ,  transient receptor potential channel ,  Motor neuron diseases ,  *metabotropic glutamate receptor

JST classification (3)： Toxicity of plant derived substances  (GZ03010J) ,  Cell physiology in general  (EF02010S) ,  Receptors on cell membrane  (EF04030C)

Substance index (10)： (S)-AMPA ,  2-APB ,  MPEP ,  NBQX ,  SKF-96365 ,  β-ODAP ,  Kainic Acid ,  Tetrodotoxin ,  Nifedipine ,  Flufenamic acid

Terms in the title (10)： 神経 ,  洞察 ,  β-ODAP ,  一過性受容体電位チャンネル ,  代謝調節 ,  グルタミン酸受容体 ,  運動ニューロン ,  蓄積 ,  細胞死 ,  誘発