Art

J-GLOBAL ID：201402241388932243   Reference number：14A0907207

Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study

高度催吐性化学療法後の化学療法誘発悪心および嘔吐の予防のためのネツピタントとパロノセトロンの経口併用NEPAの有効性と安全性 ランダム化用量範囲設定主要試験

Author (8)： HESKETH P. J. (Lahey Hospital & Medical Center, Burlington, USA) ,  ROSSI G. (Helsinn Healthcare SA, Lugano, CHE) ,  RIZZI G. (Helsinn Healthcare SA, Lugano, CHE) ,  PALMAS M. (Helsinn Healthcare SA, Lugano, CHE) ,  ALYASOVA A. (Federal Medical-Biological Agency of Russia, Nizhny Novgorod, RUS) ,  BONDARENKO I. (Dnepropetrovsk Medical Acad., Dnepropetrovsk, UKR) ,  LISYANSKAYA A. (City Clinical Oncology Dispensary, Saint Petersburg, RUS) ,  GRALLA R. J. (Albert Einstein Coll. Medicine, Bronx, USA)
Material： Annals of Oncology  (Ann Oncol)
Volume： 25  Issue： 7  Page： 1340-1346  Publication year： Jul. 2014 
JST Material Number： W0107A  ISSN： 0923-7534  CODEN： ANONE2  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： cisplatin ,...

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JST classification (2)： Clinical application of drugs acting on digestive system  (GW09020B) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (1)： Palonosetron

Reference (11)：

• Feyer P, Jordan K. Update and new trends in antiemetic therapy: the continuing need for novel therapies. Ann Oncol 2011; 22: 30-38.
• Rojas C, Slusher BS. Pharmacological mechanism of 5-HT3 and tachykinin NK-1 receptor antagonism to prevent chemotherapy-induced nausea and vomiting. Eur J Pharmacol 2012; 684: 1-7.
• Gralla R, Lichinitser M, Van Der Vegt S et al. Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized phase III trial comparing single doses of palonosetron with ondansetron. Ann Oncol 2003; 14: 1570-1577.
• Saito M, Aogi K, Sekine I et al. Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy randomized, comparative phase III trial. Lancet Oncol 2009; 10: 115-124.
• Aapro MS, Grunberg SM, Manikhas GM et al. A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. Ann Oncol 2006; 17: 1441-1449.

Terms in the title (14)： 高度催吐性化学療法 ,  化学療法 ,  誘発 ,  悪心 ,  嘔吐 ,  予防 ,  ネツピタント ,  パロノセトロン ,  併用 ,  有効性 ,  安全性 ,  ランダム化 ,  用量 ,  試験