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J-GLOBAL ID:201402242843768607   Reference number:14A0572423

Association between severe toxicity of nilotinib and UGT1A1 polymorphisms in Japanese patients with chronic myelogenous leukemia

日本人の慢性骨髄性白血病患者におけるニロチニブの重度毒性とUGT1A1多型の間の関連
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Material:
Volume: 19  Issue:Page: 391-396  Publication year: Apr. 2014 
JST Material Number: L3966A  ISSN: 1341-9625  Document type: Article
Article type: 原著論文  Country of issue: Germany, Federal Republic of (DEU)  Language: ENGLISH (EN)
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Clinical application of antitumor(=antineoplastic)drugs  ,  Drug therapy(=pharmacotherapy)for tumors  ,  Blood cell tumors(=neoplasms) 
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Reference (18):
  • Weisberg E, Manlew P, Mestan J et al (2006) AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL. Br J Cancer 94:1765–1769
  • Saglio G, Kim D, Issaragrisil S et al (2010) Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia. N Engl J Med 362:2251–2259
  • Hazarika M, Jiang X, Liu Q et al (2008) Tasigna for chronic and accelerated phase Philadelphia chromosome-positive chronic myelogenous leukemia resistant to or intolerant of imatinib. Clin Cancer Res 14:5325–5331
  • Shami PJ, Deininger M (2012) Evolving treatment strategies for patients newly diagnosed with chronic myeloid leukemia: the role of second-generation BCR-ABL inhibitors as first-line therapy. Leukemia 26:214–224
  • Kantarjian HM, Hochhaus A, Saglio G et al (2011) Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial. Lancet Oncol 12:841–851
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