Art

J-GLOBAL ID：201402254231554363   Reference number：14A0655637

Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities

気管支拡張作用および抗炎症活性を有するムスカリン受容体アンタゴ二ストであるメペンゾラート臭化物の光学異性体の合成と生物学的比較

Author (15)： YAMASHITA Yasunobu (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  TANAKA Ken-ichiro (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  ASANO Teita (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  YAMAKAWA Naoki (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  KOBAYASHI Daisuke (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  ISHIHARA Tomoaki (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  HANAYA Kengo (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  SHOJI Mitsuru (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  SUGAI Takeshi (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN) ,  WADA Mitsuhito (Technol. Res. Assoc. for Next Generation Natural Products Chemistry, 2-3-26, Aomi, Koto-ku, Tokyo 135-0064, JPN) ,  WADA Mitsuhito (Biochemical Information Project, Fujitsu Ltd., 1-9-3, Nakase, Mihama-ku, Chiba 261-8588, JPN) ,  MASHIMO Tadaaki (Technol. Res. Assoc. for Next Generation Natural Products Chemistry, 2-3-26, Aomi, Koto-ku, Tokyo 135-0064, JPN) ,  MASHIMO Tadaaki (Information and Mathematical Sci. and Bioinformatics Co., Ltd, Owl Tower, 4-21-1, Higashi-Ikebukuro, Toshima-ku ...) ,  FUKUNISHI Yoshifumi (Molecular Profiling Res. Center for Drug Discovery (molprof), National Inst. of Advanced Industrial Sci. and ...) ,  MIZUSHIMA Tohru (Fac. of Pharmacy, Keio Univ., Tokyo 105-8512, JPN)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 22  Issue： 13  Page： 3488-3497  Publication year： Jul. 01, 2014 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： bronchodilator action ,  anti-inflammatory action ,  muscarinic receptor ,  *stereoisomer ,  chronic obstructive pulmonary disease ,  carbon ,  M3 receptor ,  aromatic compound ,  hydroxy acid
Semi thesaurus term： Receptor, Muscarinic M3 ,  *optical isomer ,  anti-inflammatory activity ,  asymmetric carbon

JST classification (3)： Basic research of drugs acting on respiration and respiratory system  (GW08010J) ,  Synthesis of drugs  (GV01030F) ,  Basic medicine on respiratory system  (GI01020H)

Substance index (3)： Mepenzolate ,  Benzilic acid ,  Mepenzolate bromide

Terms in the title (7)： 気管支拡張作用 ,  抗炎症活性 ,  ムスカリン受容体 ,  スト ,  メペンゾラート臭化物 ,  光学異性体 ,  生物学的比較