Art
J-GLOBAL ID：201402257085891254   Reference number：14A0961273

Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator

フェニルイミダゾール型γ-セクレターゼモジュレータによるγ-セクレターゼのアロステリック調節
Author (21)：
TAKEO Koji

About TAKEO Koji

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
TANIMURA Shun

About TANIMURA Shun

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
SHINODA Takehiro

About SHINODA Takehiro

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
OSAWA Satoko

About OSAWA Satoko

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
ZAHARIEV Ivan Krasmirov

About ZAHARIEV Ivan Krasmirov

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
TAKEGAMI Naoki

About TAKEGAMI Naoki

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
ISHIZUKA-KATSURA Yoshiko

About ISHIZUKA-KATSURA Yoshiko

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
SHINYA Naoko

About SHINYA Naoko

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
TAKAGI-NIIDOME Shizuka

About TAKAGI-NIIDOME Shizuka

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
TOMINAGA Aya

About TOMINAGA Aya

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
OHSAWA Noboru

About OHSAWA Noboru

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
KIMURA-SOMEYA Tomomi

About KIMURA-SOMEYA Tomomi

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
SHIROUZU Mikako

About SHIROUZU Mikako

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
YOKOSHIMA Satoshi

About YOKOSHIMA Satoshi

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
YOKOYAMA Shigeyuki

About YOKOYAMA Shigeyuki

(RIKEN Center for Life Sci. Technol., Kanagawa, JPN)

About RIKEN Center for Life Sci. Technol., Kanagawa, JPN

, 
YOKOYAMA Shigeyuki

About YOKOYAMA Shigeyuki

(RIKEN Structural Biology Lab., Kanagawa, JPN)

About RIKEN Structural Biology Lab., Kanagawa, JPN

, 
FUKUYAMA Tohru

About FUKUYAMA Tohru

(Univ. Tokyo, Tokyo, JPN)

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, 
TOMITA Taisuke

About TOMITA Taisuke

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
TOMITA Taisuke

About TOMITA Taisuke

(JST-CREST, Tokyo, JPN)

About JST-CREST, Tokyo, JPN

, 
IWATSUBO Takeshi

About IWATSUBO Takeshi

(Univ. Tokyo, Tokyo, JPN)

About Univ. Tokyo, Tokyo, JPN

, 
IWATSUBO Takeshi

About IWATSUBO Takeshi

(JST-CREST, Tokyo, JPN)

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Material：
Proceedings of the National Academy of Sciences of the United States of America  (PNAS)

About Proceedings of the National Academy of Sciences of the United States of America


Volume： 111  Issue： 29  Page： 10544-10549  Publication year： Jul. 22, 2014 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)
Thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*allosteric effect

About allosteric effect

, 
*aspartic proteinase

About aspartic proteinase

, 
enzyme regulation

About enzyme regulation

, 
amyloid beta-protein

About amyloid beta-protein

, 
peptide

About peptide

, 
steric conformation

About steric conformation

, 
conformational transition

About conformational transition

, 
photoaffinity labeling

About photoaffinity labeling

, 
binding site

About binding site

, 
drug

About drug


Semi thesaurus term：
Thesaurus term/Semi thesaurus term
Keywords indexed to the article.
All keywords is available on JDreamIII(charged).
On J-GLOBAL, this item will be available after more than half a year after the record posted. In addtion, medical articles require to login to MyJ-GLOBAL.
*gamma-secretase

About gamma-secretase

, 
amyloid beta 42

About amyloid beta 42

, 
*allosteric modulator

About allosteric modulator


JST classification (2)：
JST classification
Category name(code) classified by JST.
Molecular structure 
(EB03020Y)

About Molecular structure

,  Enzyme in general 
(EB09010D)

About Enzyme in general

Substance index (1)：
Substance index
Chemical Substance indexed to the Article.
ST-1120

About ST-1120

Terms in the title (3)：
Terms in the title
Keywords automatically extracted from the title.
γ-セクレターゼ

About γ-セクレターゼ

, 
モジュレータ

About モジュレータ

, 
アロステリック調節

About アロステリック調節


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